Castration reduces potassium-stimulated norepinephrine release from superfused olfactory bulbs of male rats.

Title

Castration reduces potassium-stimulated norepinephrine release from superfused olfactory bulbs of male rats.

Creator

Guan X B; Dluzen D

Publisher

Brain research

Date

1991
1991-12

Description

In order to investigate the possible relationship among the olfactory bulb (OB), norepinephrine (NE) and gonadal steroids, we measured NE release from superfused anterior and posterior OB in intact and castrated male rats (Expt. I) as well as in castrated male rats implanted with either empty or testosterone filled silastic capsules (Expt. II). Both basal and potassium (K+ 30 mM)-stimulated release of NE was greater in posterior compared to anterior OB. All groups were responsive to the K+ stimuli showing increases in NE release. The degree of K(+)-stimulated release was significantly greater in intact compared to that of castrated rats. No differences in K(+)-stimulated release were observed between castrated and castrated plus testosterone-treated groups. These results demonstrate that castration of male rats significantly reduces OB noradrenergic responsiveness to K+ stimulation, an effect which was not restored following administration of silastic capsules containing testosterone.

Subject

*Orchiectomy; Animals; Inbred Strains; Kinetics; Male; Norepinephrine/*metabolism; Olfactory Bulb/drug effects/*physiology; Potassium/*pharmacology; Rats; Reference Values; Testosterone/*pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

147–151

Issue

1

Volume

568

Citation

Guan X B; Dluzen D, “Castration reduces potassium-stimulated norepinephrine release from superfused olfactory bulbs of male rats.,” NEOMED Bibliography Database, accessed June 12, 2021, https://neomed.omeka.net/items/show/3285.

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