The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex.

Title

The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex.

Creator

Aroniadou V A; Teyler T J

Publisher

Brain research

Date

1991
1991-10

Description

The purpose of the present study was to improve our understanding of the role of NMDA receptors in neocortical synaptic plasticity. In slices of rat visual cortex the field potential elicited in layer III in response to white matter stimulation consisted of two components with peak latencies at 5-8 ms (EPSP1) and 12-19 ms (EPSP2). EPSP2 appeared to be polysynaptic since it did not follow stimulation at 0.5 Hz. EPSP1 consisted of both kainate/AMPA and NMDA receptor activity, as revealed by bath application of DNQX and APV. EPSP2 displayed a variable sensitivity to bath-applied APV. Tetanic stimulation of the white matter in normal medium consistently induced long-term potentiation of EPSP1. In the presence of APV, LTP of EPSP1 was induced only when EPSP2 was still present, while there was no change, or LTD was induced, when EPSP2 was completely blocked by APV. In rat visual cortex, blockade of NMDA receptor participation in the postsynaptic response to tetanic stimulation reduces the probability for LTP induction but does not necessarily prevent LTP; synaptic strength may still change in either direction depending, in part, on factors affecting the magnitude of postsynaptic depolarization during tetanus.

Subject

*Cortical Spreading Depression/drug effects; 2-Amino-5-phosphonovalerate/pharmacology; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium Chloride/pharmacology; Electric Stimulation; Evoked Potentials/drug effects; Ibotenic Acid/analogs & derivatives/pharmacology; In Vitro Techniques; Kainic Acid/pharmacology; Magnesium/pharmacology; N-Methyl-D-Aspartate/drug effects/*physiology; Quinoxalines/pharmacology; Rats; Receptors; Synapses/physiology; Time Factors; Visual Cortex/drug effects/*physiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

136–143

Issue

1

Volume

562

Citation

Aroniadou V A; Teyler T J, “The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex.,” NEOMED Bibliography Database, accessed October 16, 2021, https://neomed.omeka.net/items/show/3284.

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