1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice.

Title

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice.

Creator

Dluzen D E

Publisher

Brain research

Date

1992
1992-07

Description

Male retired breeder C57/Bl and CD-1 mice were treated with either MPTP or its vehicle. At 7-10 days post-treatment, catecholamine concentrations within the olfactory bulbs (OB) and hypothalamus were determined. Norepinephrine concentrations within the OB were significantly decreased in MPTP-treated mice. These effects were more pronounced in the CD-1 (50% reduction) compared to the C57/Bl (20% reduction) strain. No effects of MPTP were observed on norepinephrine concentrations within the hypothalamus. Dopamine concentrations in the OB and hypothalamus did not differ between MPTP- and vehicle-treated mice in either strain. Overall, catecholamine concentrations within the OB, but not the hypothalamus, were significantly greater in C57/Bl compared to CD-1 mice. The reduction in OB norepinephrine concentration in the MPTP-treated animals may be related to the olfactory deficits which accompany Parkinson's disease.

Subject

*Sex Characteristics; 1-Methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine/*pharmacology; Animals; Dopamine/metabolism; Drug Resistance/genetics; Inbred C57BL; Inbred Strains; Male; Mice; Norepinephrine/*metabolism; Olfactory Bulb/*metabolism; Osmolar Concentration

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

144–147

Issue

1

Volume

586

Citation

Dluzen D E, “1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice.,” NEOMED Bibliography Database, accessed March 4, 2021, https://neomed.omeka.net/items/show/3289.

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