Antiepileptics inhibit cortical N-methyl-D-aspartate-evoked [3H]norepinephrine efflux.

Title

Antiepileptics inhibit cortical N-methyl-D-aspartate-evoked [3H]norepinephrine efflux.

Creator

Brown L M; Lee Y P; Teyler T J

Publisher

European journal of pharmacology

Date

1994
1994-03

Description

The antiepileptic drugs phenytoin, valproic acid and phenobarbital were examined for their ability to inhibit N-methyl-D-aspartate (NMDA)-stimulated [3H]norepinephrine efflux from rat brain cortical slices. All three drugs inhibited efflux at varying concentrations. Valproic acid was the most potent and inhibited efflux at 0.01 mg/ml. Phenytoin and phenobarbital inhibited efflux at 0.1 mg/ml. These results indicate that some antiepileptic drugs are capable of inhibiting NMDA receptor function in the therapeutic range.

Subject

Animals; Anticonvulsants/*pharmacology; Dose-Response Relationship; Drug; Female; Male; N-Methylaspartate/*antagonists & inhibitors; Norepinephrine/*metabolism; Rats

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

307–309

Issue

3

Volume

254

Citation

Brown L M; Lee Y P; Teyler T J, “Antiepileptics inhibit cortical N-methyl-D-aspartate-evoked [3H]norepinephrine efflux.,” NEOMED Bibliography Database, accessed May 18, 2021, https://neomed.omeka.net/items/show/3300.

Social Bookmarking