Psychostimulant-induced activity is attenuated by two putative dopamine release inhibitors.

Title

Psychostimulant-induced activity is attenuated by two putative dopamine release inhibitors.

Creator

Calcagnetti D J; Schechter M D

Publisher

Pharmacology, biochemistry, and behavior

Date

1992
1992-12

Description

Centrally administered amphetamine (AMPH), cathinone, (CATH), or cocaine (COC) have each been shown to produce elevated activity in rats and this effect is dose responsive. The question remains whether these psychostimulants share a common mechanism of action (i.e., do these psychostimulants act by releasing dopamine to increase activity levels?). Experiments were, therefore, conducted to measure the spontaneous activity of these three centrally administered psychostimulants in rats following pretreatment with two putative dopamine release inhibitors, viz.,

Subject

Alkaloids/antagonists & inhibitors; Amphetamine/antagonists & inhibitors/pharmacology; Animals; Antipsychotic Agents/pharmacology; Central Nervous System Stimulants/*antagonists & inhibitors/pharmacology; Cocaine/antagonists & inhibitors; Dopamine Antagonists; Dopamine/*physiology; Injections; Intraventricular; Isradipine/pharmacology; Male; Motor Activity/*drug effects; Psychotropic Drugs/pharmacology; Rats; Sprague-Dawley; Thiazepines/pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1023–1031

Issue

4

Volume

43

Citation

Calcagnetti D J; Schechter M D, “Psychostimulant-induced activity is attenuated by two putative dopamine release inhibitors.,” NEOMED Bibliography Database, accessed October 20, 2021, https://neomed.omeka.net/items/show/3325.

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