Psychostimulant-induced activity is attenuated by two putative dopamine release inhibitors.

Psychostimulant-induced activity is attenuated by two putative dopamine release inhibitors.

Calcagnetti D J; Schechter M D

Pharmacology, biochemistry, and behavior

1992

1992-12

Centrally administered amphetamine (AMPH), cathinone, (CATH), or cocaine (COC) have each been shown to produce elevated activity in rats and this effect is dose responsive. The question remains whether these psychostimulants share a common mechanism of action (i.e., do these psychostimulants act by releasing dopamine to increase activity levels?). Experiments were, therefore, conducted to measure the spontaneous activity of these three centrally administered psychostimulants in rats following pretreatment with two putative dopamine release inhibitors, viz.,

Alkaloids/antagonists & inhibitors; Amphetamine/antagonists & inhibitors/pharmacology; Animals; Antipsychotic Agents/pharmacology; Central Nervous System Stimulants/*antagonists & inhibitors/pharmacology; Cocaine/antagonists & inhibitors; Dopamine Antagonists; Dopamine/*physiology; Injections; Intraventricular; Isradipine/pharmacology; Male; Motor Activity/*drug effects; Psychotropic Drugs/pharmacology; Rats; Sprague-Dawley; Thiazepines/pharmacology

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1023–1031

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