Biphasic effects of ethanol tested with drug discrimination in HAD and LAD rats.

Title

Biphasic effects of ethanol tested with drug discrimination in HAD and LAD rats.

Creator

Krimmer E C

Publisher

Pharmacology, biochemistry, and behavior

Date

1992
1992-12

Description

Seventh-generation selectively bred high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats were trained to make differential responses for ethanol (0.75 g/kg, IP) and saline vehicle, following postadministration intervals (PI) of 2 min (HAD-2 and LAD-2 animals) and 30 min (HAD-30 and LAD-30 animals). ED50 values of 0.395 and 0.352 g/kg, respectively, for HAD-2 and LAD-2 animals and 0.269 and 0.314 g/kg, respectively, for HAD-30 and LAD-30 animals reflect the absence of any phenotypic difference for the discriminative stimulus effects of ethanol. HAD-2 animals were more responsive than LAD-2 animals to the stimulating effects of ethanol as measured by total response rates during training sessions. The differential ethanol response generalized to pentobarbital in all four groups but not to morphine, an alternative CNS depressant. The specific antagonist of 5-hydroxytryptamine3 receptors,

Subject

Alcohol Drinking/genetics/*psychology; Animals; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Inbred Strains; Male; Pentobarbital/pharmacology; Rats; Serotonin Antagonists/pharmacology; Sleep/drug effects; Time Factors; Tropanes/pharmacology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1233–1240

Issue

4

Volume

43

Citation

Krimmer E C, “Biphasic effects of ethanol tested with drug discrimination in HAD and LAD rats.,” NEOMED Bibliography Database, accessed April 19, 2021, https://neomed.omeka.net/items/show/3326.

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