MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats.

Title

MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats.

Creator

Meehan S M; Gordon T L; Schechter M D

Publisher

Alcohol (Fayetteville, N.Y.)

Date

1995
1995-12

Description

Selectively bred high- and low-alcohol-drinking (HAD/LAD) rats were trained to discriminate the interoceptive stimuli produced by IP-administered 600 mg/kg ethanol (10% w/v in a two-lever, food-motivated operant task. Once criterion discrimination was attained, animals were tested with 3.0, 1.5, 1.0, and 0.5 mg/kg MDMA. Although no differences in alcohol discrimination were observed between the HAD and LAD animals, the HAD line was significantly more sensitive than the LAD line to the effects of MDMA. These results provide additional information to the growing body of evidence suggesting serotonergic mediation of some of the behavioral effects of ethanol.

Subject

4-methylenedioxyamphetamine/*pharmacology; Alcohol Drinking/*genetics/psychology; Animals; Central Nervous System Depressants/*pharmacology; Cues; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Generalization; Male; N-Methyl-3; Piperazines/pharmacology; Rats; Serotonin Agents/*pharmacology; Serotonin Receptor Agonists/pharmacology; Stimulus

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

569–572

Issue

6

Volume

12

Citation

Meehan S M; Gordon T L; Schechter M D, “MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats.,” NEOMED Bibliography Database, accessed April 21, 2021, https://neomed.omeka.net/items/show/3388.

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