Cocaethylene-induced lethality in mice is potentiated by alcohol.

Title

Cocaethylene-induced lethality in mice is potentiated by alcohol.

Creator

Meehan S M; Schechter M D

Publisher

Alcohol (Fayetteville, N.Y.)

Date

1995
1995-08

Description

Mice of the heterogeneously bred HS line were concurrently administered intraperitoneal injections of either 95, 75, 60, or 48 mg/kg cocaethylene or 48, 38, or 30 mg/kg cocaethylene in conjunction with the non-lethal dose of 6.0 g/kg (20% w/v) alcohol. Results indicate that alcohol administration significantly potentiated cocaethylene-induced lethality. This observation suggests that alcohol is capable of enhancing the lethal effects of cocaethylene. Results are discussed in terms of observations of sudden death in humans who abuse cocaine and alcohol.

Subject

Animals; Cocaine/*analogs & derivatives/poisoning; Dose-Response Relationship; Drug; Drug Synergism; Ethanol/*pharmacology; Female; Inbred Strains; Lethal Dose 50; Male; Mice

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

383–385

Issue

4

Volume

12

Citation

Meehan S M; Schechter M D, “Cocaethylene-induced lethality in mice is potentiated by alcohol.,” NEOMED Bibliography Database, accessed June 29, 2022, https://neomed.omeka.net/items/show/3387.

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