Immunopathogenesis of osteoarthritis.

Title

Immunopathogenesis of osteoarthritis.

Creator

Haseeb Abdul; Haqqi Tariq M

Publisher

Clinical immunology (Orlando, Fla.)

Date

2013
2013-03

Description

Even though osteoarthritis (OA) is mainly considered as a degradative condition of the articular cartilage, there is increasing body of data demonstrating the involvement of all branches of the immune system. Genetic, metabolic or mechanical factors cause an initial injury to the cartilage resulting in release of several cartilage specific auto-antigens, which trigger the activation of immune response. Immune cells including T cells, B cells and macrophages infiltrate the joint tissues, cytokines and chemokines are released from different kinds of cells present in the joint, complement system is activated, and cartilage degrading factors such as matrix metalloproteinases (MMPs) and prostaglandin E2 (PGE2) are released, resulting in further damage to the articular cartilage. There is considerable success in the treatment of rheumatoid arthritis using anti-cytokine therapies. In OA, however, these therapies did not show much effect, highlighting more complex nature of pathogenesis of OA. This needs the development of more novel approaches to treat OA, which may include therapies that act on multiple targets. Plant natural products have this kind of property and may be considered for future drug development efforts. Here we reviewed the studies implicating different components of the immune system in the pathogenesis of OA.

Subject

Adaptive Immunity; Animals; Humans; Immunity; Innate; Osteoarthritis/*immunology; Signal Transduction

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

185–196

Issue

3

Volume

146

Citation

Haseeb Abdul; Haqqi Tariq M, “Immunopathogenesis of osteoarthritis.,” NEOMED Bibliography Database, accessed May 9, 2021, https://neomed.omeka.net/items/show/3526.

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