Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice.

Title

Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice.

Creator

Dluzen Dean E; Ji Jing; McDermott Janet L

Publisher

Neuroscience letters

Date

2010
2010-05

Description

In this report we compared three different parameters of nigrostriatal dopaminergic (NSDA) function - locomotor activity, striatal dopamine (DA) levels and 3,4-dihydroxyphenylacetic acid (DOPAC)/DA ratios between heterozygous mutant dopamine transporter mice (+/- DAT) and their wild type controls (+/+ DAT) at three different age range periods: 4-10, 11-17 and 18-24 months of age. Locomotor activity of the +/- DAT mice failed to differ over the three age periods sampled. In +/+ DAT mice a significant decrease in locomotor activity was obtained at the

Subject

3; 4-Dihydroxyphenylacetic Acid/*metabolism; Aging/*physiology; Animals; Corpus Striatum/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Dopamine/*metabolism; Heterozygote; Inbred C57BL; Knockout; Male; Mice; Motor Activity; Mutation; Substantia Nigra/*metabolism

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

66–69

Issue

2

Volume

476

Citation

Dluzen Dean E; Ji Jing; McDermott Janet L, “Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice.,” NEOMED Bibliography Database, accessed April 18, 2021, https://neomed.omeka.net/items/show/3713.

Social Bookmarking