Novel approaches to mitigating parathion toxicity: targeting cytochrome

Novel approaches to mitigating parathion toxicity: targeting cytochrome

Jan Yi-Hua; Richardson Jason R; Baker Angela A; Mishin Vladimir; Heck Diane E; Laskin Debra L; Laskin Jeffrey D

Annals of the New York Academy of Sciences

2016

2016-08

Accidental or intentional exposures to parathion, an organophosphorus (OP) pesticide, can cause severe poisoning in humans. Parathion toxicity is dependent on its metabolism by the cytochrome P450 (CYP) system to paraoxon (diethyl

*menadione; *organophosphorus pesticides; *paraoxon; *parathion; *redox cycling; Animals; Cholinesterase Inhibitors/metabolism/*toxicity; Cytochrome P-450 Enzyme Inhibitors/*administration & dosage/metabolism; Cytochrome P-450 Enzyme System/metabolism; Drug Delivery Systems/*methods; Humans; Insecticides/metabolism/toxicity; Organophosphate Poisoning/drug therapy/enzymology; Parathion/metabolism/*toxicity; Vitamin K 3/*administration & dosage/metabolism

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