Novel approaches to mitigating parathion toxicity: targeting cytochrome

Title

Novel approaches to mitigating parathion toxicity: targeting cytochrome

Creator

Jan Yi-Hua; Richardson Jason R; Baker Angela A; Mishin Vladimir; Heck Diane E; Laskin Debra L; Laskin Jeffrey D

Publisher

Annals of the New York Academy of Sciences

Date

2016
2016-08

Description

Accidental or intentional exposures to parathion, an organophosphorus (OP) pesticide, can cause severe poisoning in humans. Parathion toxicity is dependent on its metabolism by the cytochrome P450 (CYP) system to paraoxon (diethyl

Subject

*menadione; *organophosphorus pesticides; *paraoxon; *parathion; *redox cycling; Animals; Cholinesterase Inhibitors/metabolism/*toxicity; Cytochrome P-450 Enzyme Inhibitors/*administration & dosage/metabolism; Cytochrome P-450 Enzyme System/metabolism; Drug Delivery Systems/*methods; Humans; Insecticides/metabolism/toxicity; Organophosphate Poisoning/drug therapy/enzymology; Parathion/metabolism/*toxicity; Vitamin K 3/*administration & dosage/metabolism

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

80–86

Issue

1

Volume

1378

Citation

Jan Yi-Hua; Richardson Jason R; Baker Angela A; Mishin Vladimir; Heck Diane E; Laskin Debra L; Laskin Jeffrey D, “Novel approaches to mitigating parathion toxicity: targeting cytochrome,” NEOMED Bibliography Database, accessed January 23, 2021, https://neomed.omeka.net/items/show/4505.

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