Oxybutynin 3% gel for the treatment of primary focal hyperhidrosis in adolescents and young adults.

Title

Oxybutynin 3% gel for the treatment of primary focal hyperhidrosis in adolescents and young adults.

Creator

Nguyen Nicholas V; Gralla Jane; Abbott James; Bruckner Anna L

Publisher

Pediatric dermatology

Date

2018
2018-03

Description

BACKGROUND/OBJECTIVES: There are no reliably effective, well-tolerated topical agents for the treatment of hyperhidrosis. We sought to evaluate the efficacy and tolerability of oxybutynin 3% gel in adolescents and young adults with primary focal hyperhidrosis. METHODS: Patients with severe axillary hyperhidrosis were treated with topical oxybutynin 3% gel for 4 weeks. Response to treatment was assessed by calculating change in Hyperhidrosis Disease Severity Score from baseline to weeks 1 and 4. Change in health-related quality of life was assessed using the Children's Dermatology Life Quality Index or the Dermatology Life Quality Index. Adverse effects were evaluated using patient diaries, investigator global review, and physical examination. RESULTS: Of 10 patients aged 13-24 enrolled, seven completed the study. Of those who completed the study, four (57.1%) reported reduction in axillary Hyperhidrosis Disease Severity Score at week 1 and all seven (100%) at week 4. Six patients (85.7%) reported reduction in Children's Dermatology Life Quality Index or Dermatology Life Quality Index score. Anticholinergic adverse effects were infrequent. The majority of treatment-related adverse events were mild to moderate in severity. One patient experienced a severe adverse event. CONCLUSION: Oxybutynin 3% gel reduced hyperhidrosis severity and improved health-related quality of life in this small pilot study. Safety and efficacy should be further evaluated in a large, prospective, placebo-controlled study.

Subject

Administration; Adolescent; Female; Humans; hyperhidrosis; Hyperhidrosis/*drug therapy; Male; Mandelic Acids/*administration & dosage/adverse effects; oxybutynin; Parasympatholytics/*administration & dosage/adverse effects; pharmacology; Pilot Projects; Prospective Studies; quality of life; Quality of Life; Severity of Illness Index; therapy-topical; Topical; Treatment Outcome; Young Adult

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

208–212

Issue

2

Volume

35

Citation

Nguyen Nicholas V; Gralla Jane; Abbott James; Bruckner Anna L, “Oxybutynin 3% gel for the treatment of primary focal hyperhidrosis in adolescents and young adults.,” NEOMED Bibliography Database, accessed September 17, 2021, https://neomed.omeka.net/items/show/4506.

Social Bookmarking