Bile acid signaling in metabolic disease and drug therapy.

Title

Bile acid signaling in metabolic disease and drug therapy.

Creator

Li Tiangang; Chiang John Y L

Publisher

Pharmacological reviews

Date

2014
2014-10

Description

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile acids generates bile flow and facilitates hepatobiliary secretion of lipids, lipophilic metabolites, and xenobiotics. In the intestine, bile acids are essential for the absorption, transport, and metabolism of dietary fats and lipid-soluble vitamins. Extensive research in the last 2 decades has unveiled new functions of bile acids as signaling molecules and metabolic integrators. The bile acid-activated nuclear receptors farnesoid X receptor, pregnane X receptor, constitutive androstane receptor, vitamin D receptor, and G protein-coupled bile acid receptor play critical roles in the regulation of lipid, glucose, and energy metabolism, inflammation, and drug metabolism and detoxification. Bile acid synthesis exhibits a strong diurnal rhythm, which is entrained by fasting and refeeding as well as nutrient status and plays an important role for maintaining metabolic homeostasis. Recent research revealed an interaction of liver bile acids and gut microbiota in the regulation of liver metabolism. Circadian disturbance and altered gut microbiota contribute to the pathogenesis of liver diseases, inflammatory bowel diseases, nonalcoholic fatty liver disease, diabetes, and obesity. Bile acids and their derivatives are potential therapeutic agents for treating metabolic diseases of the liver.

Subject

Animals; Bile Acids and Salts/biosynthesis/*metabolism/therapeutic use; Biological; Circadian Rhythm/physiology; G-Protein-Coupled/metabolism; Glucose/metabolism; Humans; Lipid Metabolism/physiology; Liver/metabolism; Metabolic Diseases/*drug therapy/*metabolism; Microbiota/physiology; MicroRNAs/metabolism; Models; Receptors; Signal Transduction/physiology

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

948–983

Issue

4

Volume

66

Citation

Li Tiangang; Chiang John Y L, “Bile acid signaling in metabolic disease and drug therapy.,” NEOMED Bibliography Database, accessed October 28, 2021, https://neomed.omeka.net/items/show/4531.

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