Oxygen consumption after massive sympathetic nervous system discharge.

Oxygen consumption after massive sympathetic nervous system discharge.

Lang S A; Maron M B; Signs S A

The American journal of physiology

1989

1989-03

We evaluated the possibility that massive, sympathetic nervous system (SNS) activation [as may precede the development of neurogenic pulmonary edema (NPE)] increases O2 demand. O2 consumption (VO2) and plasma concentrations of the calorigenic agents, epinephrine (EPI) and norepinephrine (NE) were measured in alpha-chloralose-anesthetized dogs under control conditions and for 3 h after the administration of either 1) intracisternal (ic) veratrine to activate the SNS, 2) intravenous (iv) veratrine, 3) ic saline, or 4) ic veratrine, after clamping the adrenal blood vessels. VO2 increased 31.7 +/- 3.6% (SE), and EPI and NE increased to, respectively, 30,853 +/- 8,347 and 8,176 +/- 2,104 pg/ml in the ic veratrine group. No increases in VO2 and EPI and attenuated increases in NE were observed in the ic veratrine animals with clamped adrenals. No significant increases in VO2 or catecholamine concentrations were observed after ic saline or iv veratrine administration. These data suggest that the elevated VO2 may have been mediated by adrenal catecholamines and that an increased metabolic rate may complicate the ability of patients with severe NPE to balance O2 supply with demand.

*Blood Pressure; *Oxygen Consumption/drug effects; Adrenal Glands/physiology; Animals; Cardiac Output/drug effects; Dogs; Epinephrine/blood; Female; Heart Rate/drug effects; Male; Norepinephrine/blood; Pulmonary Artery/drug effects/physiology/physiopathology; Pulmonary Edema/physiopathology; Reference Values; Sympathetic Nervous System/*physiology/physiopathology; Veratrine/pharmacology

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