Role of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-beta and IGF signaling.

Title

Role of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-beta and IGF signaling.

Creator

Lee Chung; Jia Zhenyu; Rahmatpanah Farah; Zhang Qiang; Zi Xiaolin; McClelland Michael; Mercola Dan

Publisher

BioMed research international

Date

2014
1905-07

Description

This review postulates the role of transforming growth factor-beta (TGF-beta) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression. It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate. An interaction between

Subject

Androgens/metabolism; Animals; Disease Progression; Epithelial Cells/cytology; Estrogen/metabolism; Estrogens/metabolism; Humans; Male; Mice; Prostate/metabolism; Prostatic Neoplasms/*metabolism; Receptors; Signal Transduction; Somatomedins/*metabolism; Stromal Cells/*cytology; Transforming Growth Factor beta/*metabolism

Identifier

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

502093–502093

Volume

2014

Citation

Lee Chung; Jia Zhenyu; Rahmatpanah Farah; Zhang Qiang; Zi Xiaolin; McClelland Michael; Mercola Dan, “Role of the adjacent stroma cells in prostate cancer development and progression: synergy between TGF-beta and IGF signaling.,” NEOMED Bibliography Database, accessed April 15, 2021, https://neomed.omeka.net/items/show/4699.

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