Inverse agonist properties of the FG 7142 discriminative stimulus.

Title

Inverse agonist properties of the FG 7142 discriminative stimulus.

Creator

Leidenheimer N J; Schechter M D

Publisher

Pharmacology, biochemistry, and behavior

Date

1991
1991-01

Description

A two-lever, food-motivated discrimination was established between the benzodiazepine receptor partial inverse agonist FG 7142 (5.0 mg/kg) and its vehicle. The FG 7142 discriminative stimulus was pharmacologically characterized by testing trained rats with a variety of benzodiazepine receptor ligands. Administration of the inverse agonist DMCM (0.15-0.30 mg/kg) dose-dependently mimicked the FG 7142 stimulus. In contrast, the benzodiazepine receptor agonist chlordiazepoxide, partial agonist ZK 91 296, mixed agonist/antagonist CGS 9896 and antagonist RO 15-1788 blocked the FG 7142 cue. These results indicate that the FG 7142 discriminative stimulus is based on its inverse agonist activity. The generalization of FG 7142 to the anxiogenic/convulsant compound pentylenetetrazole (PTZ), but not to the anorectic agent norfenfluramine, indicates that the anxiogenic properties of FG 7142, rather than its anorectic actions, may underlie the FG 7142 discriminative stimulus.

Subject

Male; Animals; Rats; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Reinforcement Schedule; Appetite Depressants/*pharmacology; Carbolines/antagonists & inhibitors/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Generalization; Stimulus/drug effects; GABA-A/drug effects

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

99–104

Issue

1

Volume

38

Citation

Leidenheimer N J; Schechter M D, “Inverse agonist properties of the FG 7142 discriminative stimulus.,” NEOMED Bibliography Database, accessed September 25, 2021, https://neomed.omeka.net/items/show/5514.

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