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Tags: Sloan-Stakleff K

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Role Of Urokinase Pais In The Control Of Cancer Invasion And Metastasis

Tags: 1997, adenocarcinomas, angiogenesis, Cells, degradation, Drug News & Perspectives, Evans D M, in-vitro, inhibition, migration, Pharmacology & Pharmacy, plasminogen-activator, Receptor, Sloan-Stakleff K, tumor-metastasis

Suppression Of The Invasive Capacity Of Human Breast Cancer Cells By Inhibition Of Urokinase Plasminogen Activator Via Amiloride And B428

Tags: 2000, American Surgeon, angiogenesis, Carcinoma, Evans D M, integrins, migration, Prevention, prognostic marker, proliferation, pulmonary metastases, Receptor, Sloan-Stakleff K, Surgery, tumor-cells

Time and dose dependency of the suppression of pulmonary metastases of rat mammary cancer by amiloride.

Amiloride is an inhibitor of urokinase plasminogen activator (uPA), an essential component of the plasminogen/plasmin enzyme system. Inhibition of uPA prevents the conversion of plasminogen to tumor cell surface bound plasmin which is required for…

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