The role of TRPV4 channels in ocular function and pathologies.
Title
The role of TRPV4 channels in ocular function and pathologies.
Creator
Guarino BD;Paruchuri S;Thodeti CK
Publisher
Experimental Eye Research
Date
2020
2020-09-29
Description
Transient potential receptor vanilloid 4 (TRPV4) is an ion channel responsible for sensing osmotic and mechanical signals, which in turn regulates calcium signaling across cell membranes. TRPV4 is widely expressed throughout the body, and plays an important role in normal physiological function, as well as different pathologies, however, its role in the eye is not well known. In the eye, TRPV4 is expressed in various tissues, such as the retina, corneal epithelium, ciliary body, and the lens. In this review, we provide an overview on TRPV4 structure, activation, mutations, and summarize the current knowledge of TRPV4 function and signaling mechanisms in various locations throughout the eye, as well as its role in ocular diseases, such as glaucoma and diabetic retinopathy. Based on the available data, we highlight the therapeutic potential of TRPV4 as well as the shortcomings of current research. Finally, we provide future perspectives on the implications of targeting TRPV4 to treat various ocular pathologies. (Copyright © 2020 Elsevier Ltd. All rights reserved.)
Subject
Glaucoma; TRPV4; Angiogenesis; Retina; Calcium channel; Cornea; Diabetic retinopathy; Lens; Osmolarity
Identifier
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
journalArticle
URL Address
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Pages
108257
Volume
201
ISSN
1096-0007
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Update Year & Number
September 2020 List
Citation
Guarino BD;Paruchuri S;Thodeti CK, “The role of TRPV4 channels in ocular function and pathologies.,” NEOMED Bibliography Database, accessed September 21, 2023, https://neomed.omeka.net/items/show/11278.