The role of TRPV4 channels in ocular function and pathologies.

Title

The role of TRPV4 channels in ocular function and pathologies.

Creator

Guarino BD;Paruchuri S;Thodeti CK

Publisher

Experimental Eye Research

Date

2020
2020-09-29

Description

Transient potential receptor vanilloid 4 (TRPV4) is an ion channel responsible for sensing osmotic and mechanical signals, which in turn regulates calcium signaling across cell membranes. TRPV4 is widely expressed throughout the body, and plays an important role in normal physiological function, as well as different pathologies, however, its role in the eye is not well known. In the eye, TRPV4 is expressed in various tissues, such as the retina, corneal epithelium, ciliary body, and the lens. In this review, we provide an overview on TRPV4 structure, activation, mutations, and summarize the current knowledge of TRPV4 function and signaling mechanisms in various locations throughout the eye, as well as its role in ocular diseases, such as glaucoma and diabetic retinopathy. Based on the available data, we highlight the therapeutic potential of TRPV4 as well as the shortcomings of current research. Finally, we provide future perspectives on the implications of targeting TRPV4 to treat various ocular pathologies. (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Subject

Glaucoma; TRPV4; Angiogenesis; Retina; Calcium channel; Cornea; Diabetic retinopathy; Lens; Osmolarity

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Format

journalArticle

Search for Full-text

Users with a NEOMED Library login can search for full-text journal articles at the following url: https://libraryguides.neomed.edu/home

Pages

108257

Volume

201

ISSN

1096-0007

NEOMED College

NEOMED College of Medicine Student
NEOMED College of Medicine

NEOMED Department

NEOMED Student Publications
Department of Integrative Medical Sciences

Update Year & Number

September 2020 List

Citation

Guarino BD;Paruchuri S;Thodeti CK, “The role of TRPV4 channels in ocular function and pathologies.,” NEOMED Bibliography Database, accessed January 18, 2021, https://neomed.omeka.net/items/show/11278.

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