Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis.

Title

Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis.

Creator

Bishayee Anupam; Waghray Abhijeet; Barnes Kendra F; Mbimba Thomas; Bhatia Deepak; Chatterjee Malay; Darvesh Altaf S

Publisher

Pharmaceutical research

Date

2010
2010-06

Description

PURPOSE: Resveratrol, present in grapes and red wine, has been found to prevent diethylnitrosamine (DENA)-initiated rat liver tumorigenesis, though the chemopreventive mechanisms are not completely elucidated. The current study was designed to explore whether the antiinflammatory properties of resveratrol play a role in its antihepatocarcinogenic action. METHODS: Liver samples were harvested from a 20-week chemopreventive study in which resveratrol (50, 100 and 300 mg/kg) was shown to inhibit DENA-induced hepatocyte nodules in Sprague-Dawley rats in a dose-responsive manner. Hepatic preneoplastic and inflammatory markers, namely heat shock protein (HSP70), cyclooxygenase-2 (COX-2) and nuclear factor-kappaB (NF-kappaB), were studied using immunohistochemical as well as Western blot techniques. RESULTS: Resveratrol dose-dependently suppressed DENA-induced increased expressions of hepatic HSP70 and COX-2. Resveratrol also attenuated the

Subject

Animals; Anticarcinogenic Agents/*therapeutic use; Chemoprevention; Cyclooxygenase 2/immunology; Diethylnitrosamine; Female; HSP70 Heat-Shock Proteins/immunology; Humans; Inflammation/prevention & control; Liver Neoplasms/chemically induced/*immunology/*prevention & control; Liver/drug effects/pathology; NF-kappa B/immunology; Rats; Resveratrol; Sprague-Dawley; Stilbenes/*therapeutic use

Rights

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

Pages

1080–1091

Issue

6

Volume

27

Citation

Bishayee Anupam; Waghray Abhijeet; Barnes Kendra F; Mbimba Thomas; Bhatia Deepak; Chatterjee Malay; Darvesh Altaf S, “Suppression of the inflammatory cascade is implicated in resveratrol chemoprevention of experimental hepatocarcinogenesis.,” NEOMED Bibliography Database, accessed September 29, 2022, https://neomed.omeka.net/items/show/3245.

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