Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice.

Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice.

Dluzen D E

Brain research

1996

1996-04

We have recently reported that treatment of gonadectomized female and male C57/B1 mice with the gonadal steroid hormone, estrogen, reduced nigrostriatal dopaminergic neurotoxicity resulting from the Parkinson's-like inducing agent

*MPTP Poisoning; 1-Methyl-4-phenyl-1; 2; 3; 4-Dihydroxyphenylacetic Acid/metabolism; 6-tetrahydropyridine/*antagonists & inhibitors; Animals; Catecholamines/metabolism; Dopamine Agents/*toxicity; Dopamine/metabolism/*physiology; Female; Inbred C57BL; Male; Mice; Neostriatum/drug effects/metabolism/*pathology; Nervous System Diseases/chemically induced/*pathology/*prevention & control; Olfactory Bulb/drug effects/metabolism; Orchiectomy; Substantia Nigra/drug effects/metabolism/*pathology; Testosterone/*pharmacology

Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).

113–118

1

715