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Tags: Gilliland Tricia

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BILE ACID RECEPTORS FXR AND TGR IN LIVER FIBROSIS AND INFLAMMATION: STUDY OF FXR/TGR5 DOUBLE KNOCKOUT MICE

Tags: 2019, Boehme Shannon, Chiang John Y L, Department of Integrative Medical Sciences, Ferrell Jessica M, Gilliland Tricia, Hepatology, Journal Article, NEOMED College of Medicine, November 2019 Update

Deficiency of both farnesoid X receptor and Takeda G protein-coupled receptor 5 exacerbated liver fibrosis in mice.

Activation of the nuclear bile acid receptor farnesoid X receptor (FXR) protects against hepatic inflammation and injury, while Takeda G protein-coupled receptor 5 (TGR5) promotes adipose tissue browning and energy metabolism. Here, we examined the…

Tags: 2019, Bile acid metabolism, Boehme Shannon, Chiang John Y L, Department of Integrative Medical Sciences, Ferrell Jessica M, FXR, Gene Expression, Gilliland Tricia, hepatic fibrosis, Hepatology (Baltimore, Md.), NEOMED College of Medicine, Pathak Preeti, TGR5

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