Browse Items · NEOMED Bibliography Database

Cocaethylene produces discriminative stimulus properties in the rat: effect of cocaine and ethanol coadministration.

Experimentally naive Sprague-Dawley male rats were trained to discriminate the interoceptive stimulus cues produced by either 10.0 mg/kg cocaine or 10.0 mg/kg cocaethylene from their saline vehicles. Although it required more sessions to train the…

Tags: 1995, Animals, Cocaine/*analogs & derivatives/pharmacokinetics/*pharmacology, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Ethanol/pharmacokinetics/*pharmacology, Male, Pharmacology, biochemistry, and behavior, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley

Differential training sequence effect upon psychostimulant discrimination.

1. Previous studies indicate that rats trained to discriminate either cathinone or cathine from its vehicle have a diminished discriminative performance when tested 24 hours after a drug administration when compared to tests conducted after a vehicle…

Tags: 1993, Alkaloids/pharmacology, Animals, Appetite Depressants/pharmacology, Central Nervous System Stimulants/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Food, Male, Phenylpropanolamine/pharmacology, Progress in neuro-psychopharmacology & biological psychiatry, Psychotropic Drugs/pharmacology, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley

Lesions of the basolateral amygdala abolish the ability of drug associated cues to reinstate responding during withdrawal from self-administered cocaine.

This study investigated the ability of bilateral excitotoxic lesions of the basolateral amygdala (BLA) to disrupt cocaine self-administration, responding during extinction sessions, and stimulus cued recovery of extinguished responding in rats. BLA…

Increased drug sensitivity in the drug discrimination procedure afforded by drug versus drug training.

Rats were trained to discriminate norfenfluramine (NF) 1.4 mg/kg from its vehicle or amphetamine (AMPH) 0.8 mg/kg or pentobarbital (PB) 6.0 mg/kg in order to determine the role that drug combination training plays in the rate of learning and…

Tags: 1990, Amphetamine/pharmacology, Animals, Boja J W, Discrimination (Psychology)/*drug effects, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Inbred Strains, Male, Norfenfluramine/pharmacology, Pentobarbital/pharmacology, Psychopharmacology, Rats, Reinforcement Schedule, Schechter M D

Inverse agonist properties of the FG 7142 discriminative stimulus.

A two-lever, food-motivated discrimination was established between the benzodiazepine receptor partial inverse agonist FG 7142 (5.0 mg/kg) and its vehicle. The FG 7142 discriminative stimulus was pharmacologically characterized by testing trained…

Tags: 1991, Animals, Appetite Depressants/*pharmacology, Carbolines/antagonists & inhibitors/*pharmacology, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, GABA-A/drug effects, Generalization, Inbred Strains, Leidenheimer N J, Male, Pharmacology, biochemistry, and behavior, Rats, Receptors, Reinforcement Schedule, Schechter M D, Stimulus/drug effects

Discriminative stimulus effect of phenylephrine.

Rats were trained to discriminate phenylephrine in a two-lever, food-motivated operant task by increasing the i.p. administered training dose from 0.8 to 2 mg/kg. Stable discrimination to 2 mg/kg phenylephrine was established and testing of 0.5-2.5…

Functional consequences of fenfluramine neurotoxicity.

Male Sprague-Dawley rats were trained to discriminate the anorectic drug d,l-fenfluramine (2.0 mg/kg intraperitoneally administered) from its vehicle using a food-motivated (fixed-ratio 10 schedule) two-lever operant task. Once trained, doses of 0.5,…

Tags: 1990, Animals, Conditioning, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, Fenfluramine/*toxicity, Inbred Strains, Male, Nervous System Diseases/*chemically induced/psychology, Operant/drug effects, Pharmacology, biochemistry, and behavior, Rats, Reinforcement Schedule, Schechter M D

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