An update on the association of vitamin D deficiency with common infectious diseases.

An update on the association of vitamin D deficiency with common infectious diseases.

Watkins Richard R; Lemonovich Tracy L; Salata Robert A

Canadian journal of physiology and pharmacology

2015

2015-05

Vitamin D plays an important role in modulating the immune response to infections. Deficiency of vitamin D is a common condition, affecting both the general population and patients in health care facilities. Over the last decade, an increasing body of evidence has shown an association between vitamin D deficiency and an increased risk for acquiring several infectious diseases, as well as poorer outcomes in vitamin D deficient patients with infections. This review details recent developments in understanding the role of vitamin D in immunity, the antibacterial actions of vitamin D, the association between vitamin D deficiency and common infections (like sepsis, pneumonia, influenza, methicillin-resistant Staphylococcus aureus, human immunodeficiency virus type-1 (HIV), and hepatitis C virus (HCV)), potential therapeutic implications for vitamin D replacement, and future research directions.

Adaptive Immunity/immunology; Animals; Communicable Diseases/*diagnosis/drug therapy/*immunology; HIV; Humans; immunite; immunity; Immunity; Innate/immunology; MRSA; pneumonia; pneumonie; SARM; sepsis; Sepsis/diagnosis/drug therapy/immunology; septicemie; therapy; traitement; VIH; vitamin D; Vitamin D Deficiency/*diagnosis/drug therapy/*immunology; Vitamin D/*immunology/therapeutic use; vitamine D

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363–368

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