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Tags: Tauopathies/complications/genetics

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Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease.

Reduced bone mineral density (BMD) and its clinical sequelae, osteoporosis, occur at a much greater rate in patients with Alzheimer's disease (AD), often emerging early in the disease before significant cognitive decline is seen. Reduced BMD…

Tags: *Alzheimer Disease/complications/genetics/pathology, *Alzheimer's disease, *bone density, *microtubule-associated protein, *serotonin, *tau proteins, *tauopathies, 2017, Age Factors, Alzheimer's disease, Alzheimer's Disease – Complications, Alzheimer's Disease – Pathology, Animal, Animal Studies, Animals, Biological, Body Composition, Body Composition/genetics, Body Weight, Body Weight/genetics, Bone Density – Physiology, Bone Density/*physiology, Bone Diseases – Etiology, Bone Diseases/*etiology, Brain Stem – Pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Disease Models, Dorsal Raphe Nucleus/*pathology, Female, Inbred C57BL, Journal of Alzheimer's disease : JAD, Male, Mice, Models, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurons – Metabolism, Neurons – Pathology, Neurons/metabolism/pathology, Oxidoreductases – Metabolism, Phosphorylation, Serotonin – Metabolism, Serotonin/*metabolism, Smith Matthew A, tau Proteins/*genetics/metabolism, Tauopathies/complications/genetics, Transgenic, Tryptophan Hydroxylase/metabolism, Wilson Gina N

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