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Isradipine produces neither a conditioned place preference nor aversion.

Isradipine (ISR) has been reported to block cocaine-induced conditioned place preference. Using this procedure, the pairing of this L-type calcium blocker, at doses of 2.5, 5.0 and 10 mg/kg, with a preferred (cue-distinct) environment was…

Tags: 1994, Animals, Calcagnetti D J, Cocaine/*pharmacology, Conditioning, Isradipine/administration & dosage/*pharmacology, Life sciences, Male, Operant/*drug effects, Rats, Schechter M D, Sprague-Dawley

Olfactory bulbectomy disrupts the expression of cocaine-induced conditioned place preference.

The role of the olfactory sense in the expression of cocaine-induced conditioned place preference (CPP) was examined in adult male rats (n = 35) of the N/Nih strain. Consistent with the scientific literature, rats were observed to significantly (p…

Discriminative stimulus properties of isradipine: effect of other calcium channel blockers.

This study constitutes the first report of a calcium channel blocker used as a drug capable of controlling differential responding in a drug-discrimination paradigm. Male Sprague-Dawley rats were trained to discriminate between intraperitoneally…

Tags: 1995, Animals, Calcium Channel Blockers/*pharmacology, Conditioning, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Generalization, Isradipine/*pharmacology, Male, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Sprague-Dawley, Stimulus/*drug effects

Cocaethylene produces conditioned place preference in rats.

The ability of cocaethylene to produce either a conditioned place preference or a conditioned place aversion was tested in rats. Twelve male rats were administered 10 mg/kg cocaethylene and confined to their nonpreferred side of the conditioned place…

Tags: 1995, Animals, Avoidance Learning/drug effects, Cocaine/*analogs & derivatives/pharmacology, Conditioning, Discrimination (Psychology)/drug effects, Male, Motor Activity/*drug effects, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Sprague-Dawley

Reducing the time needed to conduct conditioned place preference testing.

The objective of the present experiment was to demonstrate whether four days of twice-a-day conditioned place conditioning produces a preference that is equivalent to that produced by using eight days of once-a-day training. Two doses of the…

Tags: 1992, Alkaloids/pharmacology, Animals, Calcagnetti D J, Choice Behavior/*drug effects, Conditioning, Experimental/instrumentation/methods, Inbred Strains, Male, Motor Activity/drug effects, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Psychology, Psychotropic Drugs/pharmacology, Rats, Schechter M D

Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.

1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats…

Nicotine place preference using the biased method of conditioning.

1. The objective of the experimentation was to determine whether nicotine (NIC, 0.8 mg/kg subcutaneously administered) would produce a conditioned place preference (CPP) in rats confined for thirty min to their less-preferred side in a three…

Tags: 1994, Animals, Calcagnetti D J, Conditioning, Cues, Injections, Male, Motor Activity/drug effects, Nicotine/*pharmacology, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Rats, Schechter M D, Sprague-Dawley, Subcutaneous

Scopolamine-physostigmine combination does not substitute for nicotine.

1. Male Sprague-Dawley rats were trained to discriminate 0.4 mg/kg nicotine subcutaneously administered from its saline vehicle in a food-motivated operant discrimination task. Once trained, the discriminative performance was observed to be…

Extinction of cocaine-induced place approach in rats: a validation of the "biased" conditioning procedure.

It has often been demonstrated that when a rat is conditioned in a cue-specific environment that has been repeatedly paired with cocaine injections, it will spend more time in that environment than it does in a saline-paired environment. This…

Tags: 1993, Animals, Brain research bulletin, Calcagnetti D J, Classical, Cocaine/*pharmacology, Conditioning, Extinction, Habituation, Inbred Strains, Male, Operant/*drug effects, Psychological/*drug effects, Psychophysiologic/drug effects, Rats, Reward, Schechter M D

Olanzapine attenuates the reinforcing effects of cocaine.

The possibility that the atypical neuroleptic olanzapine can antagonize the ability of cocaine to produce both conditioned place preference and self-administration in rats was investigated. Pre-treatment with olanzapine (3.0, 4.5 mg/kg, but not 1.5…

Discriminative characteristics of high and low cocaine administration: effect of other psychostimulants.

Two groups of N/Nih male rats were trained to discriminate saline vehicle from either 2.0 mg/kg (n = 10) or 10.0 mg/kg (n = 10) cocaine in a food-motivated, two-lever operant paradigm. The rats trained at the low-dose cocaine took a significantly…

LSD produces conditioned place preference in male but not female fawn hooded rats.

Male and female Fawn Hooded rats were examined for conditioned place preference (CPP) or aversion (CPA) to lysergic acid diethylamide (LSD). Using a biased design, experimental animals were trained with LSD (0.2 mg/kg, I.P.) administered in…

Tags: *Cues, *Sex Characteristics, 1998, Analysis of Variance, Animals, Choice Behavior/*drug effects, Conditioning, Female, Humans, Inbred Strains, Lysergic Acid Diethylamide/*pharmacology, Male, Meehan S M, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D

Effect of repeated administrations upon cathinone discrimination and conditioned place preference.

1. Eight male rats were trained to discriminate the interoceptive cues produced by 0.8 mg/kg l-cathinone in a two-lever, food-motivated operant task and they were, subsequently, tested for preference to cathinone in a conditioned place preference…

Tags: 1991, Alkaloids/*pharmacology, Animals, Conditioning, Department of Anatomy & Neurobiology, Discrimination (Psychology)/*drug effects, Drug Tolerance/physiology, General pharmacology, Inbred Strains, Male, McBurney D, NEOMED College of Medicine, Operant/*drug effects, Psychotropic Drugs/*pharmacology, Rats, Schechter M D

Effect of learned behavior upon conditioned place preference to cathinone.

The purpose of this study was to examine whether first training rats to discriminate the stimulus cues produced by an indirect dopamine agonist, cathinone, would influence a subsequent test of preference. The conditioned place preference (CPP)…

Tags: 1991, Alkaloids/*pharmacology, Animals, Antipsychotic Agents/pharmacology, Conditioning, Cues, Discrimination (Psychology)/drug effects, Discrimination Learning/drug effects, Dopamine/drug effects, Dopamine/physiology, Inbred Strains, Learning/*physiology, Male, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Thiazepines/pharmacology

Lack of generalization of nisoxetine with amphetamine in the rat.

Rats were trained to discriminate between the stimulus properties of intraperitoneally administered d-amphetamine (0.8 mg/kg) and its vehicle in a two-lever, food-motivated operant task. Once trained, doses of the norepinephrine reuptake inhibiting…

Tags: *Discrimination (Psychology), 1988, Animals, Boja J W, Conditioning, Dextroamphetamine/*pharmacology, Dose-Response Relationship, Drug, Fluoxetine/*analogs & derivatives/pharmacology, Inbred Strains, Male, Norepinephrine/antagonists & inhibitors, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Reference Values, Schechter M D

Temporal parameters of cathinone, amphetamine and cocaine.

Rats were trained to discriminate intraperitoneally administered 0.8 mg/kg

Tags: 1989, Alkaloids/*pharmacology, Amphetamines/*pharmacology, Animals, Cocaine/*pharmacology, Conditioning, Discrimination (Psychology)/*drug effects, Inbred Strains, Male, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Task Performance and Analysis, Time Factors

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