A 67-year-old woman had fever, myalgias, progressive weakness, and respiratory insufficiency. In 9 days, flaccid areflexic quadriparesis and bulbar palsy developed. She died 26 days after the onset of her illness. Serum and cerebrospinal fluid…
Pesticides are unique environmental contaminants that are specifically introduced into the environment to control pests, often by killing them. Although pesticide application serves many important purposes, including protection against crop loss and…
Perspectives are in the eye of the beholder and are expanded with increased scrutiny (e.g., magnification). The term porosity' for macroscopically or radiologically identifiable discontinuity in bone is so variably applied as to be incomprehensible…
Background.-Extramammary Paget's disease most commonly occurs on the female external genitalia and rarely occurs in the perianal region and male external genitalia. We present the clinical and pathologic features of 5 cases of perianal Paget's…
Alzheimer's disease (AD) is accompanied by a robust inflammatory response mediated by plaque-associated myeloid cells of the brain. These cells exhibit altered gene expression profiles and serve as a barrier, preventing neuritic dystrophy. The origin…
A 3-year-old girl with rhizomelic chondrodysplasia punctata (RCDP) had severe micrencephaly but a normal gyral pattern, neuronal density, and cortical cytoarchitecture. The white matter was diffusely decreased in mass but normally myelinated. There…
Two unusual bumps occur on the internal surface of a rib of the marine reptile Prognathodon saturator from the Upper Cretaceous (Maastrichtian) of Maastricht, The Netherlands. These bumps are interpreted as stress fractures, possibly related to…
As the study of bone disease in recent and fossil amphibians and reptiles has evolved from observational speculation to analysis of testable hypotheses, so too has recognition of its contribution to our understanding of diseases and organisms. Given…
Examination of preserved skin from a duckbill dinosaur revealed disruption of the normal scale pattern and replacement by granulation tissue. Wrinkles radiating outward from the scar document wound contraction similar to that seen in modern injuries.…
The cytogenetic findings in pleuropulmonary blastoma (PPB) have not been widely studied and reported and are of interest in view of the implications that PPB has for additional tumors in the patient and the patient's relatives. Using standard tumor…
Thin section and freeze-fracture transmission electron microscopy were used to examine and identify the cytoplasmic and membrane structures in a cell line derived from a melanotic neuroectodermal tumor of infancy (MNTI). The cultured cells had a…
Renal complications of Waldenstrom's macroglobulinemia (WM) are rarely observed. Nephrotic syndrome in association with WM has most often been secondary to amyloidosis. This article reports a case of WM with nephrotic syndrome as a result of…
