The mechanism of antiviral action of tricyclodecan-9-yl-xanthogenate (D609) was investigated in vitro. D609 inhibited herpes simplex virus type 1 (HSV-1) replication without apparent cytotoxicity. It reduced phosphorylation of virus-infected cell…
The Ligand Epitope Antigen Presentation System ( L. E. A. P. S. TM) approach to vaccine development utilizes immune peptides to promote the immunogenicity and influence the type of immune response generated towards epitopes in peptides which may be…
Vaccines have eliminated diseases such as syphilis and malaria from many regions of the world and because they are administered a few times at most they are more cost-effective than many drugs that treat the same conditions. However vaccines are not…
Addition of tromantadine after virus penetration inhibited HSV-1 induced syncytium formation and virus production in HEp-2 and VERO cells and acted additively with neutralizing antibody in blocking virus spread and cytopathology. Inhibition of…
Two generations of amphiphilic membranes synthesized in our laboratories for biologicaUniedical applications are highlighted. Recent results obtained with representative 2nd generation membranes designed specifically for immunoencapsulation of…
Despite the large number of vaccines, this review asks the question: why do we not have vaccines for all infectious diseases? The first of this series discussed basics of vaccine immunology, new approaches, and outlined some of the difficulties and…
Despite the large number of vaccines, this review asks the question "Why don'twe have vaccines for all infectious diseases?" The first and second parts of this series discussed basics of vaccine immunology and new approaches and outlined some of the…
