The cholesterol 7 alpha -hydroxylase gene (CYP7A1) plays an important role in regulation of bile acid biosynthesis and cholesterol homeostasis. Oxysterol receptor, LXR, stimulates, whereas the bile acid receptor, FXR, inhibits CYP7A1 transcription.…
Study objective: To measure the in vivo rate of alveolar epithelial fluid clearance of the human lung in patients with pulmonary alveolar phospholipoproteinosis (PAP). Design: Prospective clinical study. Setting: The medical-surgical ICUs of a…
Hydrophobic bile acids strongly repressed transcription of the human cholesterol 7 alpha -hydroxylase gene (CYP7A1) in the bile acid biosynthetic pathway in the Ever. Farnesoid X receptor (FXR) repressed CYP7A1/Luc reporter activity in a transfection…
BACKGROUND: Hemolytic anemia associated with benign pelvic neoplasms is very rare. Sixteen cases have been reported in the English-language literature. CASE: A 27-year-old woman complained of dizziness, fatigue and headache. Physical Examination…
Objective: To estimate the independent contribution of birth weight to asthma prevalence among children younger than 4 years in the United States and to compare the magnitude of its effect on asthma between African American and white children.…
The present study investigated a conceptual framework for relating medical specialty choice to personality. The model was tested by examining personality differences among general surgeons, anesthesiologists, and family practice physicians. The 16…
Spondyloarthropathy was observed in 25 (2.8%) of 895 preserved canid museum specimens and was catalogued by species. The associated skeletal alterations in canids are indistinguishable grossly and physiologically from those in humans with…
Our hypothesis is that in an established Level I trauma center general trauma surgeons should repair peripheral vascular injuries even in stable patients when there is time for a vascular consult. We reviewed all penetrating peripheral vascular…
The digital rectal examination is widely accepted as an essential component in the initial assessment of trauma. However, no data have been published that justify its routine use in all seriously injured patients. The objective of this study was to…
Objective: To describe physicians' and patients' reasons for participating in office-based sales of dermatologic products. Design: Survey data on the attitudes, opinions, and beliefs of dermatologists and their patients were analyzed. Setting: A…
Objective: To perform a systematic review of the emergency medicine literature to assess the appropriateness of an intervention to identify, counsel, and refer emergency department (ED) patients > 64 years old who are at high risk for falls. Methods:…
Our objective was to describe and compare the use of complementary and alternative medicine (CAM) in gynecology and gynecological oncology patients. Five hundred and twenty-nine gynecology and gynecological oncology patients completed a questionnaire…
The cranial anatomy of Megalohyrax eoceanus Andrews, 1903, a pliohyracid (Hyracoidea, Mammalia) from Oligocene levels of the Jebel Qatrani Formation of the Fayum Depression in Egypt, is described. Megalohyrax is the largest of the Fayum hyracoids,…
We present a summary of the Eocene mammal faunas of Indo-Pakistan based on study of the known faunas and new collections. New taxa described here are the carpolestid Parvocristes oligocollis, the plesiadapid Jattadectes mamikheli (both new families…
Human prostate cancer cells (DU145) implanted into nude mice are deficient in DNase activity. After administration of a vitamin C/vitamin K-3 combination, both alkaline DNase (DNase I) and acid DNase (DNase II) activities were detected in…
