Odontocete cetaceans have undergone profound modifications to their integument and sensory systems and are generally thought to lack specialized exocrine glands that in terrestrial mammals function to produce chemical signals (Thewissen & Nummela,…
Metallo-β–lactamases (MBLs) are zinc-containing carbapenemases that inactivate a broad range of β–lactam antibiotics. There is a lack of β–lactamase inhibitors for restoring existing β–lactam antibiotics arsenals against common bacterial infections.…
Suicides by any method, plus ‘nonsuicide’ fatalities from drug self-intoxication (estimated from selected forensically undetermined and ‘accidental’ deaths), together represent self-injury mortality (SIM)—fatalities due to mental disorders or…
Successively measured two-alternative forced-choice response time latencies often display sequential dependencies in their durations. This propensity is a long-recognized empirical puzzle in the decision-making literature e.g., (see Hyman, 1953;…
Streptococcus pneumoniae is a causative agent of community-acquired pneumonia (CAP). The 13-valent pneumococcal conjugate vaccine (PCV13) has significantly decreased the burden of PCV13-serotype pneumococcal disease; however, disease from nonvaccine…
MicroRNAs (miRNAs) are small regulatory molecules that are involved in posttranscriptional modifications. These noncoding RNAs are usually ferried by extracellular carriers such as exosomes or other protein and lipid carriers inside a range of body…
There are more than 100,000 cases of esophageal foreign body in the United States each year. Most cases resolve spontaneously; however, complete esophageal obstruction is a medical emergency. Patients with developmental disabilities are at high risk,…
Mitochondria are the center for oxidative phosphorylation, metabolism, and reactive oxygen species (ROS) production in the cell and home for several proapoptotic proteins. Therefore, tight regulation of mitochondrial health and function is essential…
Transient receptor potential vanilloid 4 (TRPV4) is a ubiquitously expressed polymodally activated ion channel. TRPV4 has been implicated in tumor progression; however, the cell-specific role of TRPV4 in tumor growth, angiogenesis, and metastasis is…
Pediatric palliative care (PPC) benefits patients and families, while potentially creating emotional and resource-management burdens for providers. This study's purpose was to characterize the occurrence of deaths attended by PPC providers outside of…
Emergency department (ED) patients who leave before treatment is complete (LBTC) represent medicolegal risk and lost revenue. We sought to examine LBTC return visits characteristics and potential revenue effects for a large healthcare system.
Neural hyperactivity induced by sound exposure often correlates with the development of hyperacusis and/or tinnitus. In laboratory animals, hyperactivity is typically induced by unilateral sound exposure to preserve one ear for further testing of…
Enalapril is a prodrug and needs to be activated by carboxylesterase 1 (CES1). A previous in vitro study demonstrated the CES1 genetic variant, G143E (rs71647871), significantly impaired enalapril activation. Two previous clinical studies examined…
As the Editor-in-Chief of the Journal of Ultrasound in Medicine (JUM), I am proud to provide this overview of the state of your journal. Last year (2020), JUM had arguably one of its best years on record, building on its reputation as the leading…
Lung transplantation has become an established therapy for end-stage lung diseases. Early postoperative complications can impact immediate, mid-term, and long-term outcomes. Appropriate management, prevention, and early detection of these early…
Cisplatin chemotherapy often causes permanent hearing loss, which leads to a multifaceted decrease in quality of life. Identification of early cisplatin-induced cochlear damage would greatly improve clinical diagnosis and provide potential drug…
Concerns over gadolinium (Gd) retention encourage the use of lower Gd doses. However, lower Gd doses may compromise imaging performance. Higher relaxivity gadobenate may be suited to reduced dose protocols.
Birth weight is an important predictor of neuromotor and physiological performance in early perinatal development of mammals [1–4]. Our knowledge of the impact of birth weight on growth and performance falls into two broad categories of research.…
Exceptionally long-lived species, including many bats, rarely show overt signs of aging, making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (DNAm) profiles from 712 known-age bats, representing 26 species,…
Colon cancer survival is dependent on metastatic potential and treatment. Large RNA-sequencing data sets may assist in identifying colon cancer-specific biomarkers to improve patient outcomes.
Side-effects from the COVID-19 vaccine are well-documented. In a recent published letter, anaphylaxis to mRNA COVID vaccines was cited to occur in 2.5 to 11.1 cases per million doses (2). The Centers for Disease Control and Prevention has recommended…
Successful use of early, repeat fecal microbiota transplantation for initial treatment of severe, refractory Clostridioides difficile colitis, Catherine M. Cappetto. Am J Health-Syst Pharm. 14 April 2021 (Case Report).
Transient global amnesia (TGA) presents as an acute anterograde amnesia that generally resolves within 24 h.1 Werner et al. had noted increasing TGA since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in their hospital in…
Hepatic steatosis is a condition frequently encountered in clinical practice, with potential progression towards fibrosis, cirrhosis, and hepatocellular carcinoma. Detection and staging of hepatic steatosis are of most importance in nonalcoholic…
Pharmacy practice continues to change and therefore requires lifelong health professions education. These practice changes require academics and leaders in pharmacy to identify how to best teach and train pharmacists to manage patient care services.…
An increasing number of studies show that listeners often have difficulty hearing in situations with background noise, despite normal tuning curves in quiet. One potential source of this difficulty could be sensorineural changes in the auditory…
Cardiac pathologies, such as aortic stenosis (AS), aortic regurgitation (AR), mitral regurgitation (MR), bicuspid aortic valve (BAV), LV hypertrophy/dilation, and reduced EF can be associated with ascending aortic aneurysm (AsAoA). Since non-gated…
We read the paper by Smith et al,1 which suggested that chocolate consumption was associated with lower adiposity, but wanted to express concern about the paper and methodology. Single exposure to chocolate in cross-sectional data collected via a…
The general practice of any modern medical specialty is rooted in evidence-based principles shaped by research. The discipline of metabolic and bariatric surgery is no exception. An abundant number of studies in our field utilize data from large and…
PURPOSE:To characterize the effects of eye muscle surgery on patients older than 18 years with infantile nystagmus syndrome (INS) who have had only optical treatment.
Acetylcholine (ACh) is a neuromodulator that has been implicated in multiple roles across the brain, including the central auditory system, where it sets neuronal excitability and gain and affects plasticity. In the cerebral cortex, subtypes of…
Shear wave elastography is an ultrasound-based imaging modality that can delineate prostate lesions that are stiffer, possibly due to cancerous changes. Using evidence from 16 published studies, including more than 2200 patients with suspected or…
The skull of the bowhead whale is composed of all the bones commonly found in mammals, although the shape of these bones is far from ordinary. Features related to feeding dominate the skull: there are no teeth, and the rostrum is long and curved,…
The prenatal development of bowhead whales is poorly known, and no complete ontogenetic series exist. However, the available embryos and fetuses elucidate aspects of the development of the species, as well as that of all of mysticetes in general, and…
Bering–Chukchi–Beaufort Sea bowhead whales are born at about 4.2 m in length and 1000 kg, in lead systems along the NW Alaskan coast. Bowheads in the other northern stocks are also born in ice-covered seas. Maximum body lengths (standard measure) can…
We discuss the evolution, phylogenetic relations to right whales, and geographical distribution of bowhead whales. We summarize its relations to humans, including whaling by indigenous and European whalers, conservation efforts, and modern challenges…
Indigenous whalers know a great deal about the habits and environment of bowhead whales. That knowledge is essential for safe and effective hunting and has also been invaluable to scientific research and management of bowheads. Studies in Chukotka,…
The commercial hunt of the four stocks of bowhead whales by the nations of Europe and North America commenced in 1540 and came to an effective end at the start of World War I. At that time, all four stocks had been driven to near extinction. Whalers…
In the late 1980s, annual carbon isotope cycles in the baleen plates of bowhead whales formed the basis of the first effective means of estimating bowhead age. However, the baleen aging method could only be used for aging subadult whales less than…
