Browse Items · NEOMED Bibliography Database

Serotonergic mediation of cocaine seizures in mice.

We used genetically heterogeneous HS mice to investigate the effects of drugs that alter brain concentrations of serotonin on cocaine-induced convulsions and lethality. The racemer of fenfluramine, which increases synaptic serotonin, was…

Role of dopamine D1 receptors in cocaine lethality.

One group of heterogeneously bred HS mice was assigned to test coadministration of the selective D1 antagonist SCH 23390 with a dose of cocaine (95 mg/kg) that was observed to produce 80% lethality, whereas a second group was tested by cotreatment…

Tags: 1995, Animals, Benzazepines/pharmacology, Cocaine/*toxicity, Dopamine Agonists/pharmacology, Dopamine D1/agonists/antagonists & inhibitors/*drug effects, Female, Inbred Strains, Lethal Dose 50, Male, Meehan S M, Mice, Pharmacology, biochemistry, and behavior, Phenanthridines/pharmacology, Receptors, Schechter M D, Sex Characteristics

Genetic selection for nicotine activity in mice correlates with conditioned place preference.

Genetically heterogenous stock (HS) mice are being used to develop lines which have differential locomotor response to subcutaneously administered (0.75 mg/kg) nicotine. These groups of nicotine-depressed, nicotine-activated or randomly bred control…

Tags: *Conditioning, 1995, Analysis of Variance, Animals, European journal of pharmacology, Female, Inbred Strains, Male, Meehan S M, Mice, Movement/*drug effects, Nicotine/*pharmacology, Operant, Schechter J B, Schechter M D

Direct microinjection of cathinone into the rat brain produces discriminative stimuli.

Rats were trained to discriminate IP administration of 800 micrograms/kg cathinone using a food-motivated, two-lever discrimination procedure. Following training, 800 micrograms/kg cathinone discrimination was produced (generalized) by lower…

Interaction of ethanol and tetrahydro-beta-carboline (THBC) in a discriminative task.

Rats (n = 10) were trained to discriminate between ethanol (600 mg/kg, IP) and its vehicle, or between THBC (20 mg/kg) and its vehicle in a two-lever food-motivated operant task. Once the discriminative training criterion was attained, rats in each…

Tags: 1988, Alcohol (Fayetteville, N.Y.), Animal/drug effects, Animals, Behavior, Carbolines/*pharmacology, Conditioning (Psychology)/drug effects, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Interactions, Ethanol/*pharmacology, Inbred Strains, Male, Rats, Schechter M D, Signs S A

Stability of the stimulus properties of drugs over time.

Three separate groups of rats were trained to discriminate the stimulus effects of either 600 mg/kg ethanol (n = 5), 0.8 mg/kg d-amphetamine (n = 8) or 1.0 mg/kg

Tags: *Discrimination (Psychology), 1989, Animals, Boja J W, Dextroamphetamine/*pharmacology, Dose-Response Relationship, Drug, Drug Tolerance, Ethanol/*pharmacology, Inbred Strains, Pharmacology, biochemistry, and behavior, Piperazines/*pharmacology, Rats, Schechter M D, Signs S A

The role of dopamine and serotonin receptors in the mediation of the ethanol interoceptive cue.

The drug discrimination paradigm was used to evaluate the contribution of dopamine or serotonin receptors in the mediation of the stimulus properties of ethanol. Briefly, rats were trained to discriminate between ethanol (600 mg/kg, IP) and water…

Tags: 1988, Animals, Conditioning, Cues, Discrimination (Psychology)/*physiology, Dopamine/drug effects/*physiology, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Inbred Strains, Male, Operant/physiology, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Serotonin/drug effects/*physiology, Signs S A

A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE.

The antinociceptive properties of intrathecally (i.t.) administered [D-Ala2,

Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat.

Specific behaviors comprising the serotonin syndrome (low body posture, forepaw treading, headweaving) and the autonomic signs of piloerection and salivation were determined and analyzed with locomotor activity in response to MDMA at three doses…

Projections from the medial agranular cortex to brain stem visuomotor centers in rats.

Projections from medial agranular cortex to brain stem in rat were determined by use of the anterograde tracers Phaseolus vulgaris leucoagglutinin, or wheat germ agglutinin conjugated horseradish peroxidase. Axonal trajectories were also followed by…

Tags: 1990, Animals, Brain Stem/*cytology, Cerebral Cortex/*cytology, Experimental brain research, Female, Horseradish Peroxidase, Immunohistochemistry, Inbred Strains, Male, Newman D B, Phytohemagglutinins, Rats, Stuesse S L, Visual Pathways/*anatomy & histology, Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate, Wheat Germ Agglutinins

The development of long-term potentiation in hippocampus and neocortex.

The development of long-term potentiation (LTP), an enduring alteration in synaptic efficacy following afferent activation, was examined in CA1 hippocampus and primary visual cortex of rat. Both regions show little LTP prior to postnatal day 5,…

Sharing of sensory terminals between the dynamic bag1 and static bag2 fibers in the rat muscle spindle.

The nuclear bag1 intrafusal fiber mediates the dynamic (velocity) sensitivity, whereas the nuclear bag2 and nuclear chain fibers mediate the static (length) sensitivity of muscle spindles to stretch. The pattern of branching of primary and secondary…

Tags: 1987, Afferent/*ultrastructure, Animals, Axons/ultrastructure, Brain research, Female, Inbred Strains, Kucera J, Muscle Spindles/*ultrastructure, Nerve Fibers/*ultrastructure, Neurons, Rats, Walro J M

Innervation of regenerated spindles in muscle grafts of the rat.

Features of the nerve supply and the encapsulated fibers of muscle spindles were assessed in grafted and normal extensor digitorum longus (EDL) muscles of rats by analysis of serial 10-microns frozen transverse sections stained for enzymes which…

Non-neural and neural expression of myosin heavy chains by regenerated intrafusal fibers of rats.

Expression of myosin heavy chain (MHC) isoforms was studied in rat soleus (SOL) and extensor digitorum longus (EDL) muscles which regenerated in the presence or absence of innervation. Frozen sections of two 5 day denervated SOL and EDL grafts, two…

Tags: *Muscle Denervation, *Nerve Regeneration, 1991, Afferent/*metabolism, Animals, Female, Inbred Strains, Kucera J, Motor Endplate/metabolism, Muscles/*metabolism/transplantation, Myosins/analysis/*biosynthesis, Narvy R, Neurons, Neuroscience letters, Organ Specificity, Rats, Walro J M

Tamoxifen increases methamphetamine-evoked dopamine output from superfused striatal tissue fragments of male mice.

The antiestrogen, tamoxifen (TMX), has been shown to function as a neuroprotectant against the nigrostriatal dopaminergic (NSDA) neurotoxin, methamphetamine (MA), within male mice. In the present report, we examined the effects of a combined infusion…

Tags: 2004, Animals, Brain research, Corpus Striatum/*drug effects/*metabolism, Dluzen Dean E, Dopamine Agents/*pharmacology, Dopamine Plasma Membrane Transport Proteins, Dopamine/*metabolism, Drug Synergism, Estrogen Antagonists/*pharmacology, Inbred Strains, Male, Membrane Glycoproteins/metabolism, Membrane Transport Proteins/metabolism, Methamphetamine/*pharmacology, Mice, Nerve Tissue Proteins/metabolism, Tamoxifen/*pharmacology, Willett Matthew C

A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis.

The neurochemical heterogeneity of the rat striatum was assessed in vivo by measuring subregional changes in extracellular dopamine and DOPAC by in vivo electrochemistry and microdialysis in response to amphetamine and the D2 antagonist,…

Tags: 1990, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Amphetamines/*pharmacology, Animals, Brain research, Corpus Striatum/*metabolism, Dopamine D2, Dopamine/*metabolism, Dopamine/drug effects, Electrochemistry, Inbred Strains, Male, Pehek E A, Rats, Receptors, Sulpiride/*pharmacology, Yamamoto B K

The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.

The effects of the recently classified Schedule I amphetamine analog, 3,4-methylenedioxymethamphetamine [+/-)-MDMA) on caudate and nucleus accumbens dopamine release and metabolism were studied by in vivo voltammetry and HPLC with electrochemical…

Tags: 1988, 3, 4-Dihydroxyphenylacetic Acid/metabolism, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animals, Brain/drug effects/metabolism, Caudate Nucleus/drug effects/metabolism, Consciousness, Dopamine/*metabolism, European journal of pharmacology, Inbred Strains, Male, N-Methyl-3, Nucleus Accumbens/drug effects/metabolism, Rats, Spanos L J, Yamamoto B K

Browse Items (97 total)