Browse Items (6 total)
- Tags: Interleukin-1beta/*pharmacology
A noninflammatory interleukin-1beta fragment stimulates fetal lung fluid absorption in guinea pigs.
Tags: 2007, Absorption, Adrenergic, Adrenocorticotropic Hormone/blood, Animals, Beard LaMonta L, beta/analysis, Body Fluids/drug effects/metabolism, Department of Integrative Medical Sciences, Epithelial Sodium Channels/genetics, Female, Fetus/drug effects, Folkesson Hans G, Guinea Pigs, Hydrocortisone/biosynthesis, Interleukin-1beta/*pharmacology, Li Tianbo, Lung/*drug effects/metabolism, Messenger/analysis, NEOMED College of Medicine, Oxytocin/pharmacology, Peptide Fragments/*pharmacology, Pregnancy, Receptors, RNA, The Journal of pharmacology and experimental therapeutics, Varadarajulu Shilpa, Yun June
IL-1beta-induced cortisol stimulates lung fluid absorption in fetal guinea pigs via SGK-mediated Nedd4-2 inhibition.
Tags: 2009, Absorption/drug effects, American journal of physiology. Lung cellular and molecular physiology, Animals, Base Sequence, Body Fluids/metabolism, DNA/genetics, Endosomal Sorting Complexes Required for Transport, Epithelial Sodium Channels/metabolism, Female, Folkesson Hans G, Guinea Pigs, Hydrocortisone/*biosynthesis/blood/physiology, Immediate-Early Proteins/genetics/*metabolism, Interleukin-1beta/*pharmacology, Koshy Shyny, Li Tianbo, Lung/*drug effects/*physiology, Molecular Sequence Data, Nedd4 Ubiquitin Protein Ligases, Pregnancy, Protein-Serine-Threonine Kinases/genetics/*metabolism, Recombinant Proteins/pharmacology, Ubiquitin-Protein Ligases/*antagonists & inhibitors/genetics
Sucrose, But Not Glucose, Blocks IL1-beta-Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT/mTOR Pathway.
Tags: *AUTOPHAGY, *CHONDROCYTES, *OSTEOARTHRITIS, *SUCROSE, 2017, Adult, Aged, Ansari Mohammad Y, Autophagy/*drug effects, Chondrocytes/*metabolism/pathology, Department of Anatomy & Neurobiology, Female, Glucose/*pharmacology, Haqqi Tariq M, Humans, Inflammation/chemically induced/metabolism/pathology, Interleukin-1beta/*pharmacology, Journal of cellular biochemistry, Khan Nazir M, Male, Middle Aged, NEOMED College of Medicine, Osteoarthritis/*metabolism/pathology, Proto-Oncogene Proteins c-akt/*metabolism, Signal Transduction/*drug effects, Sucrose/*pharmacology, TOR Serine-Threonine Kinases/*metabolism
Wogonin, a natural flavonoid, intercalates with genomic DNA and exhibits protective effects in IL-1beta stimulated osteoarthritis chondrocytes.
Tags: 2017, Ahmad Imran, Ansari Mohammad Y, Apoptosis/drug effects, Binding Sites, Cells, Chemico-biological interactions, Chondrocytes/cytology/*drug effects/metabolism, Chondroprotective effects, Cultured, Denaturation, Department of Anatomy & Neurobiology, DNA binding, DNA/chemistry/*metabolism, Flavanones/chemistry/metabolism/*pharmacology, Flavonoids/chemistry/pharmacology, Fluorescence Resonance Energy Transfer, Haqqi Tariq M, Humans, Intercalating Agents/chemistry/metabolism/*pharmacology, Interleukin-1beta/*pharmacology, Khan Nazir M, Molecular Docking Simulation, NEOMED College of Medicine, Nucleic Acid Conformation, Osteoarthritis, Osteoarthritis/metabolism/pathology, Protective Agents/chemistry/metabolism/*pharmacology, Reactive Oxygen Species/metabolism, Up-Regulation/drug effects, Wogonin
A standardized extract of Butea monosperma (Lam.) flowers suppresses the
Tags: *Butea, 2017, Aged, Ansari Mohammad Y, Autophagy, Autophagy/drug effects/physiology, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Butea monosperma (Lam.), Chondrocytes/drug effects/*metabolism, Department of Anatomy & Neurobiology, Dose-Response Relationship, Drug, Flowers, Gene Expression, Haqqi Tariq M, Humans, Interleukin-1beta/*pharmacology, Interleukin-6/*biosynthesis/genetics, Khan Nazir M, Matrix Metalloproteinase 13/biosynthesis/genetics, Matrix Metalloproteinase 3/biosynthesis/genetics, Matrix Metalloproteinase 9/biosynthesis/genetics, Matrix Metalloproteinases/*biosynthesis/genetics, Middle Aged, mTOR, NEOMED College of Medicine, Nutraceuticals, Osteoarthritis, Osteoarthritis/*metabolism, Plant Extracts/isolation & purification/pharmacology
Butein Activates Autophagy Through AMPK/TSC2/ULK1/mTOR Pathway to Inhibit IL-6 Expression in IL-1beta Stimulated Human Chondrocytes.
Tags: 2018, Ahmad Nashrah, AMP-Activated Protein Kinases/metabolism, AMPK, Ansari Mohammad Y, Articular/cytology/pathology, Autophagy, Autophagy-Related Protein 5/antagonists & inhibitors/genetics/metabolism, Autophagy-Related Protein-1 Homolog/metabolism, Autophagy/*drug effects, Butein, Cartilage, Cell Survival/drug effects, Cells, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Chalcones/*pharmacology, Chondrocytes/cytology/drug effects/metabolism, Cultured, Department of Anatomy & Neurobiology, Haqqi Tariq M, Humans, Inflammation, Interleukin-1beta/*pharmacology, Interleukin-6/genetics/*metabolism, Intracellular Signaling Peptides and Proteins/metabolism, mTOR, NEOMED College of Medicine, Osteoarthritis, Osteoarthritis/metabolism/pathology, Phosphorylation/drug effects, Reactive Oxygen Species/metabolism, RNA, RNA Interference, Signal Transduction/*drug effects, Small Interfering/metabolism, TOR Serine-Threonine Kinases/metabolism, TSC2, Tuberous Sclerosis Complex 2 Protein, Tumor Suppressor Proteins/metabolism, ULK1