Browse Items · NEOMED Bibliography Database

Serotonergic mediation of cocaine seizures in mice.

We used genetically heterogeneous HS mice to investigate the effects of drugs that alter brain concentrations of serotonin on cocaine-induced convulsions and lethality. The racemer of fenfluramine, which increases synaptic serotonin, was…

Biphasic effects of ethanol tested with drug discrimination in HAD and LAD rats.

Seventh-generation selectively bred high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats were trained to make differential responses for ethanol (0.75 g/kg, IP) and saline vehicle, following postadministration intervals (PI) of 2 min…

Tags: 1992, Alcohol Drinking/genetics/*psychology, Animals, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Inbred Strains, Krimmer E C, Male, Pentobarbital/pharmacology, Pharmacology, biochemistry, and behavior, Rats, Serotonin Antagonists/pharmacology, Sleep/drug effects, Time Factors, Tropanes/pharmacology

Rats bred for differences in preference to cocaine: other behavioral measurements.

Cocaine has repeatedly been shown to produce conditioned place preference (CPP) in the rat. The present study employed the heterogenous N/Nih rat stock to produce a selectively bred rat line determined by individual place preference to a conditioning…

Tags: 1992, Animal/*drug effects, Animals, Behavior, Choice Behavior/*drug effects, Cocaine/*pharmacology, Dose-Response Relationship, Drug, Female, Inbred Strains, Male, Motor Activity/drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Species Specificity, Sprague-Dawley

Further evidence for the mechanisms that may mediate nicotine discrimination.

Rats were trained to discriminate the interoceptive stimuli produced by subcutaneously administered 0.4 mg/kg nicotine in a two-lever, food-motivated, operant task. Once criterion performance was attained, dose-response experiments indicated an ED50…

Tags: 1992, Animals, Calcium Channel Blockers/pharmacology, Dihydropyridines/pharmacology, Discrimination Learning, Dopamine/*metabolism, Dose-Response Relationship, Drug, Inbred Strains, Indoles/pharmacology, Isradipine, Male, Meehan S M, Nicotine/administration & dosage/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/pharmacology, Tropisetron

Effect of altering dopamine or serotonin neurotransmitters upon cathinone discrimination.

Rats were trained to discriminate between the stimulus properties of 0.8 mg/kg l-cathinone and its vehicle in a two-lever, food-motivated operant task. Once trained, rats showed a dose-related decrease in discriminative performance when tested with…

Direct microinjection of cathinone into the rat brain produces discriminative stimuli.

Rats were trained to discriminate IP administration of 800 micrograms/kg cathinone using a food-motivated, two-lever discrimination procedure. Following training, 800 micrograms/kg cathinone discrimination was produced (generalized) by lower…

Conditioned place aversion following the central administration of a novel dopamine release inhibitor CGS 10746B.

Numerous drugs of abuse that elevate brain extracellular dopamine concentrations by either increasing the firing rate of dopaminergic neurons or producing dopamine release have been shown to reliably condition a preference for place. If dopamine…

Tags: 1991, Animals, Antipsychotic Agents/administration & dosage/*pharmacology, Avoidance Learning/*drug effects, Calcagnetti D J, Dopamine/*metabolism, Inbred Strains, Injections, Intraventricular, Male, Motor Activity/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/administration & dosage/*pharmacology

Lack of neuroleptic-like activity of l-fenfluramine.

Rats were trained to differentiate between the dopaminergically mediated discriminative stimuli produced by intraperitoneal administration of 4.8 mg/kg cathine and its vehicle. Once trained, three doses of l-fenfluramine (1.0, 2.0 and 2.5 mg/kg) were…

Tags: 1991, Animals, Antipsychotic Agents/*pharmacology, Cues, Discrimination (Psychology)/drug effects, Dopamine Agents/pharmacology, Dopamine Antagonists, Fenfluramine/*pharmacology, Inbred Strains, Male, Pharmacology, biochemistry, and behavior, Phenylpropanolamine/pharmacology, Rats, Schechter M D

Serotonin contributes to the spinal antinociceptive effects of morphine.

This study was designed to determine if morphine administered intrathecally (IT) interacts with serotonergic or noradrenergic nerve terminals in the spinal cord to produce analgesia on the spinally mediated tail-flick test. Male Sprague-Dawley rats…

Place conditioning reveals the rewarding aspect of social interaction in juvenile rats.

Rewards, as diverse as food, sweetened solutions, copulation, electrical brain stimulation, and drugs abused by humans, have been shown to condition place preferences in rats. Juvenile rats will readily learn to traverse a T-maze for the opportunity…

Tags: *Conditioning, *Motivation, *Social Behavior, *Social Environment, *Social Isolation, 1992, Animals, Calcagnetti D J, Classical/drug effects, Female, Inbred Strains, Male, Motor Activity/drug effects, Physiology & behavior, Play and Playthings, Rats, Schechter M D, Scopolamine/pharmacology, Social Dominance

Discriminative effects of cocaethylene in rats trained to discriminate cocaine or ethanol.

Two groups of rats were trained to discriminate between the stimulus properties of either intraperitoneally administered 10.0 mg/kg cocaine or 60 mg/kg ethanol and its vehicle in a two-lever operant chamber. Once trained, both groups exhibited a…

Tags: 1994, Animals, Cocaine/*analogs & derivatives/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Interactions, Ethanol/*pharmacology, Inbred Strains, Life sciences, Male, Rats, Schechter M D

Genetic selection for nicotine activity in mice correlates with conditioned place preference.

Genetically heterogenous stock (HS) mice are being used to develop lines which have differential locomotor response to subcutaneously administered (0.75 mg/kg) nicotine. These groups of nicotine-depressed, nicotine-activated or randomly bred control…

Tags: *Conditioning, 1995, Analysis of Variance, Animals, European journal of pharmacology, Female, Inbred Strains, Male, Meehan S M, Mice, Movement/*drug effects, Nicotine/*pharmacology, Operant, Schechter J B, Schechter M D

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice.

Male retired breeder C57/Bl and CD-1 mice were treated with either MPTP or its vehicle. At 7-10 days post-treatment, catecholamine concentrations within the olfactory bulbs (OB) and hypothalamus were determined. Norepinephrine concentrations within…

Tags: *Sex Characteristics, 1-Methyl-4-phenyl-1, 1992, 2, 3, 6-tetrahydropyridine/*pharmacology, Animals, Brain research, Dluzen D E, Dopamine/metabolism, Drug Resistance/genetics, Inbred C57BL, Inbred Strains, Male, Mice, Norepinephrine/*metabolism, Olfactory Bulb/*metabolism, Osmolar Concentration

Puberty acceleration in female mice induced with a partially purified male urine extract: effects on catecholamine release from the olfactory bulbs and hypothalamus.

In the present experiment peri-pubertal female mice were treated with a partially purified puberty accelerating urine extract (PAUE). Mice treated with the PAUE showed an advance in the onset of puberty as indicated by significantly increased uterine…

Tags: *Sex Characteristics, 1992, Animals, Brain research, Catecholamines/*metabolism, Dluzen D, Female, Guan X, Hypothalamus, Inbred Strains, Male, Mice, Middle/*metabolism, Olfactory Bulb/*metabolism, Sexual Maturation/*physiology, Urine/*physiology, Vandenbergh J G

Castration reduces potassium-stimulated norepinephrine release from superfused olfactory bulbs of male rats.

In order to investigate the possible relationship among the olfactory bulb (OB), norepinephrine (NE) and gonadal steroids, we measured NE release from superfused anterior and posterior OB in intact and castrated male rats (Expt. I) as well as in…

Tags: *Orchiectomy, 1991, Animals, Brain research, Dluzen D, Guan X B, Inbred Strains, Kinetics, Male, Norepinephrine/*metabolism, Olfactory Bulb/drug effects/*physiology, Potassium/*pharmacology, Rats, Reference Values, Testosterone/*pharmacology

Nomifensine alters sex differences in striatal dopaminergic function.

A series of three experiments are presented in which the acute effects of the catecholamine reuptake inhibitor, nomifensine, upon striatal dopaminergic function are compared in female and male mice. In Experiment 1, treatment with nomifensine (5 mg…

NMDA receptor-independent LTP in basal versus apical dendrites of CA1 pyramidal cells in rat hippocampal slice.

The ability of hippocampal CA1 basal synapses to express N-methyl-D-aspartate (NMDA) receptor-independent long-term potentiation (non-NMDA LTP) was studied and compared to the simultaneously induced apical dendritic non-NMDA LTP. Non-NMDA LTP in…

Browse Items (97 total)