Browse Items · NEOMED Bibliography Database

Diagnosis and treatment of diabetic foot infections.

Prompt clinical diagnosis and timely treatment are the hallmarks of the proper care of diabetic patients with foot infections. The importance of careful clinical foot examination cannot be overemphasized. When infection is suspected, effort should be…

Tags: 1999, Anti-Bacterial Agents/*therapeutic use, Bacterial Infections/*diagnostic imaging/*drug therapy, Bailliere's best practice & research. Clinical rheumatology, Department of Internal Medicine, Diabetic Foot/*microbiology, File T M Jr, Humans, NEOMED College of Medicine, Radiography, Tan J S

The epidemiology of respiratory tract infections.

Respiratory tract infections (RTIs) are the most common, and potentially most severe, of infections treated by health care practitioners. Lower RTIs along with influenza, are the most common cause of death by infection in the United States. Risk…

Colon sarcoidosis presenting with abdominal pain.

Chlamydia pneumoniae pneumonia.

Chlamydia pneumoniae is a common cause of community-acquired pneumonia. At present there is no "gold” standard for diagnosis and there is no easily accessible means of rapid diagnosis available. The best indication of acute C. pneumoniae infection is…

Tags: 2000, Department of Internal Medicine, File T M Jr, NEOMED College of Medicine, Seminars in respiratory and critical care medicine, Tan J S

Neonatal renal cystic diseases.

PURPOSE: Neonatal renal cystic diseases have a great impact on the morbidity and mortality of the affected neonates and infants. A good insight into the pathophysiology, diagnosis and treatment options of various neonatal renal cystic diseases aid in…

On the path to untreatable infections: colistin use in agriculture and the end of 'last resort' antibiotics.

Using beta-lactam/beta-lactamase inhibitors for infections due to extended-spectrum beta-lactamase-producing Enterobacteriaceae to slow the emergence of carbapenem-resistant Enterobacteriaceae.

A formidable foe: carbapenem-resistant Acinetobacter baumannii and emerging nonantibiotic therapies.

Rapidly progressive dyspnea in gastrointestinal stromal tumor (GIST) with imatinib cardiac toxicity.

Gastrointestinal stromal tumors (GISTs) are rare and current estimates range from 4,000 to 6,000 number of GIST cases in the USA annually. Imatinib, a tyrosine kinase inhibitor, has shown a survival benefit in GISTs, and the presence of KIT mutation…

Tags: 2018, Bhayani Shahzeem, cardiac toxicity, Department of Internal Medicine, fluid retention, Garg Sudershan K, Gastrointestinal stromal tumors, Gemmel David J, Ghias Adnan Asif Parvez, GISTs, Heart failure, imatinib, imatinib toxicity, Journal of community hospital internal medicine perspectives, LV dysfunction, NEOMED College of Medicine, rare

Headaches in a pregnant woman with a history of preeclampsia.

Tags: 1993, Adrenal Gland Neoplasms/*complications/diagnosis, Adult, Department of Internal Medicine, Female, Gonzalez M D, Headache/*etiology, Hospital practice (Office ed.), Humans, NEOMED College of Medicine, Pheochromocytoma/*complications/diagnosis, Pre-Eclampsia/*complications, Pregnancy, Pregnancy Complications/*etiology, Rutecki G W, Whittier F C

Weight loss and bedtime weakness.

Tags: *Weight Loss, 1994, Adult, Department of Internal Medicine, Greifenstein E, Hospital practice (Office ed.), Humans, Hyperthyroidism/*complications/physiopathology/therapy, Hypokalemia/etiology, Hypoparathyroidism/etiology, Iodine Radioisotopes/adverse effects/therapeutic use, Male, NEOMED College of Medicine, Paralysis/*etiology, Recurrence, Rudick J, Rutecki G W, Thyrotoxicosis/*complications/physiopathology/therapy, Torabzadeh S

Appropriate use of antimicrobials for drug-resistant pneumonia: focus on the significance of beta-lactam-resistant Streptococcus pneumoniae.

The beta-lactam antibiotics (penicillins and cephalosporins) are commonly prescribed for the treatment of community-acquired pneumonia. However, Streptococcus pneumoniae, the most common etiologic agent of community-acquired pneumonia, has become…

Tags: *beta-Lactam Resistance, 2002, beta-Lactams/economics/*therapeutic use, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Contraindications, Department of Internal Medicine, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumococcal/*drug therapy/economics/pathology, Pneumonia, Practice Guidelines as Topic, Streptococcus pneumoniae/*drug effects/metabolism

Clinical efficacy of newer agents in short-duration therapy for community-acquired pneumonia.

Streptococcus pneumoniae, the most important respiratory tract pathogen implicated in community-acquired pneumonia (CAP), is becoming increasingly resistant in vitro to the beta -lactams and macrolides, and fluoroquinolone resistance has been…

Tags: 2004, Anti-Infective Agents/*therapeutic use, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Community-Acquired Infections/*drug therapy/microbiology, Department of Internal Medicine, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumonia/*drug therapy/microbiology, Streptococcus pneumoniae/drug effects/isolation & purification, Treatment Outcome

Clinical characteristics of Chlamydia pneumoniae infection as the sole cause of community-acquired pneumonia.

The clinical characteristics of 26 patients with community-acquired pneumonia due to Chlamydia pneumoniae as the only identified pathogen who required hospitalization were evaluated. Most patients (18) had reinfection based on serological results.…

What can we learn from the time course of untreated and partially treated community-onset Streptococcus pneumoniae pneumonia? A clinical perspective on superiority and noninferiority trial designs for mild community-acquired pneumonia.

There are no well-designed placebo-controlled clinical trials in the recent era that precisely define the magnitude of the drug effect of antimicrobial therapy for mild community-acquired pneumonia (CAP). However, there is evidence that ineffective…

Tags: *Research Design, 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Community-Acquired Infections/*drug therapy/microbiology, Department of Internal Medicine, Disease Progression, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumococcal/*drug therapy/microbiology, Pneumonia, Randomized Controlled Trials as Topic/*methods, Schentag Jerome J, Streptococcus pneumoniae/*isolation & purification, Time Factors, Treatment Outcome

Predisposing factors and antibiotic use in nosocomial infections caused by Xanthomonas maltophilia.

Tags: *Xanthomonas/isolation & purification, 1992, Anti-Bacterial Agents/*therapeutic use, Cross Infection/*drug therapy/microbiology, Department of Internal Medicine, File T M, Gram-Negative Bacterial Infections/*drug therapy/microbiology, Hulisz D T, Humans, Infection control and hospital epidemiology, NEOMED College of Medicine, Risk Factors

Recommendations for treatment of hospital-acquired and ventilator-associated pneumonia: review of recent international guidelines.

Recently published guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia are reviewed for recommendations regarding diagnosis and antimicrobial therapy to assess the implications for development of future…

Tags: *Practice Guidelines as Topic, 2010, Anti-Bacterial Agents/*therapeutic use, Bacteria/drug effects/isolation & purification, Bacterial/diagnosis/*drug therapy, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Clinical Trials as Topic, Cross Infection/diagnosis/*drug therapy, Department of Internal Medicine, File Thomas M Jr, Hospitals, Humans, Microbial Sensitivity Tests, NEOMED College of Medicine, Pneumonia, Time Factors, Ventilator-Associated/diagnosis/*drug therapy

Integrated analysis of FOCUS 1 and FOCUS 2: randomized, doubled-blinded, multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia.

BACKGROUND: Ceftaroline, the active form of ceftaroline fosamil, is a broad-spectrum cephalosporin with bactericidal activity against pathogens causing community-acquired pneumonia (CAP), including Streptococcus pneumoniae. Ceftaroline was evaluated…

Transition of patients from chronic kidney disease to end-stage renal disease: better practices for better outcomes.

Tags: 2006, Amedia Chester A, Anemia/complications, Cardiovascular Diseases/complications, Chronic Disease, Chronic/complications/*therapy, Department of Internal Medicine, Disease management : DM, Humans, Hypertension/complications, Kidney Diseases/complications/*therapy, Kidney Failure, NEOMED College of Medicine, Perazella Mark A, Practice Guidelines as Topic

Integrating Structured Learning and Scholarly Activities into Clerkship Rotations: A Win-Win for Students and Preceptors.

Objective: To merge scholarly activity into the curriculum developed for medical students electing a rotation in wound care and/or dermatology. Approach: The authors adapted the unique wound care curriculum developed for medical student rotators and…

Tags: 2014, Advances in wound care, Department of Internal Medicine, Fulton Judith, Miller Stephannie, Mostow Eliot, NEOMED College of Medicine

Strategies for improving antimicrobial use and the role of antimicrobial stewardship programs.

Life-threatening respiratory pasteurellosis associated with palliative pet care.

Pasteurella multocida is a zoonotic Gram-negative cocco-bacillus often associated with soft tissue infections due to dog and cat bites. Here we report 3 patients who developed life-threatening P. multocida respiratory tract infections after providing…

Summary of ceftaroline fosamil clinical trial studies and clinical safety.

In October 2010, the new cephalosporin, ceftaroline fosamil, was approved by the US Food and Drug Administration for therapy of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSIs). The active…

Tags: 2012, Anti-Bacterial Agents/adverse effects/*therapeutic use, Bacterial/drug therapy, Cephalosporins/adverse effects/*therapeutic use, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Clinical Trials as Topic, Department of Internal Medicine, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumonia, Staphylococcal Skin Infections/drug therapy, Stein Gary E, Wilcox Mark H

Approaches to Modifying the Behavior of Clinicians Who Are Noncompliant With Antimicrobial Stewardship Program Guidelines.

Antimicrobial stewardship programs (ASPs) are a key national initiative to promote appropriate use of antibiotics and to reduce the burden of resistance. The dilemma of managing the outlier physician is especially complex. We outline strategies to…

SOLITAIRE-IV: A Randomized, Double-Blind, Multicenter Study Comparing the Efficacy and Safety of Intravenous-to-Oral Solithromycin to Intravenous-to-Oral Moxifloxacin for Treatment of Community-Acquired Bacterial Pneumonia.

BACKGROUND: Solithromycin, a novel macrolide antibiotic with both intravenous and oral formulations dosed once daily, has completed 2 global phase 3 trials for treatment of community-acquired bacterial pneumonia. METHODS: A total of 863 adults with…

Tags: *clinical trial, *Community-acquired, *Pneumonia, *solithromycin, *Streptococcus pneumoniae, 2016, 80 and over, Administration, Adult, Aged, Anti-Bacterial Agents/*administration & dosage/adverse effects, Bacterial, Bacterial/diagnosis/*drug therapy/*microbiology, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Community-Acquired Infections/diagnosis/*drug therapy/*microbiology, Comorbidity, Das Anita F, Department of Internal Medicine, Drug Resistance, Female, Fernandes Prabhavathi, File Thomas M Jr, Fluoroquinolones/*administration & dosage/adverse effects, Gonong Joven Roque V, Humans, Intravenous, Jamieson Brian D, Keedy Kara, Macrolides/*administration & dosage/adverse effects, Male, Microbial Sensitivity Tests, Middle Aged, Moxifloxacin, NEOMED College of Medicine, Oldach David, Oral, Pneumonia, Rewerska Barbara, Sheets Amanda, Taylor David, Treatment Outcome, Triazoles/*administration & dosage/adverse effects, Vucinic-Mihailovic Violeta

Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality.

Background: Polymyxins including colistin are an important "last-line" treatment for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKp). Increasing use of colistin has led to resistance to this cationic antimicrobial peptide.…

Tags: *beta-Lactam Resistance, *carbapenem-resistant Enterobacteriaceae, *Colistin, *Klebsiella pneumoniae, *mortality, *ST258, 2017, Aged, Anti-Bacterial Agents/pharmacology/*therapeutic use, beta-Lactamases/genetics, Bonomo Robert A, Carbapenems/pharmacology/therapeutic use, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Cober Eric, Colistin/pharmacology/*therapeutic use, Comorbidity, Department of Internal Medicine, Doi Yohei, Domitrovic T Nicholas, Evans Scott, Female, Fowler Vance G Jr, Hujer Andrea M, Hujer Kristine M, Humans, Kalayjian Robert C, Kaplan-Meier Estimate, Kaye Keith S, Klebsiella Infections/diagnosis/*drug therapy/*microbiology/mortality, Klebsiella pneumoniae/classification/*drug effects/genetics, Male, Marshall Steve, Microbial Sensitivity Tests, Middle Aged, NEOMED College of Medicine, Perez Federico, Phylogeny, Proportional Hazards Models, Richter Sandra S, Rojas Laura J, Rudin Susan D, Salata Robert A, Salim Madiha, van Duin David, Watkins Richard R

Reply to Bush and Kaye.

Tags: 2017, Bauer Karri A, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Department of Internal Medicine, File Thomas M Jr, Goff Debra A, Kullar Ravina, NEOMED College of Medicine

Increasing Evidence of the Nephrotoxicity of Piperacillin/Tazobactam and Vancomycin Combination Therapy-What Is the Clinician to Do?

Early administration of appropriate empiric antibiotics is essential for achieving the best possible outcomes in sepsis. Yet the choice of antibiotic therapy has become more challenging due to recent reports of nephrotoxicity with the combination of…

Tags: 2017, Anti-Bacterial Agents/administration & dosage/*adverse effects/therapeutic use/*toxicity, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Combination/*adverse effects, Combined Modality Therapy/*adverse effects, Department of Internal Medicine, Deresinski Stan, Drug Therapy, Humans, Kidney Diseases/*chemically induced, Kidney/*drug effects/pathology, NEOMED College of Medicine, nephrotoxicity, Penicillanic Acid/administration & dosage/adverse effects/analogs & derivatives/therapeutic use/toxicity, Piperacillin, Piperacillin/administration & dosage/adverse effects/therapeutic use/toxicity, piperacillin/tazobactam, sepsis, Sepsis/drug therapy, Tazobactam Drug Combination, vancomycin, Vancomycin/administration & dosage/adverse effects/therapeutic use/toxicity, Watkins Richard R

Colistin Versus Ceftazidime-Avibactam in the Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae.

Background: The efficacy of ceftazidime-avibactam-a cephalosporin-beta-lactamase inhibitor combination with in vitro activity against Klebsiella pneumoniae carbapenemase-producing carbapenem-resistant Enterobacteriaceae (CRE)-compared with colistin…

Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenza.

These clinical practice guidelines are an update of the guidelines published by the Infectious Diseases Society of America (IDSA) in 2009, prior to the 2009 H1N1 influenza pandemic. This document addresses new information regarding diagnostic…

Clostridium innocuum endocarditis.

Clostridial endocarditis is rare. We describe, to our knowledge, the first case of Clostridium innocuum endocarditis. The fatal case involved the tricuspid and pulmonary valves and was associated with multiple pulmonary emboli. We review the…

Tags: 1995, Adolescent, Bacterial/*etiology, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Clostridium Infections/*etiology, Cutrona A F, Department of Internal Medicine, Endocarditis, Fatal Outcome, Female, Heart Valve Diseases/etiology, Humans, Jagetia A, NEOMED College of Medicine, Pulmonary Embolism/etiology, Pulmonary Valve, Schaub C R, Tricuspid Valve, Watanakunakorn C

Can aggressive treatment of diabetic foot infections reduce the need for above-ankle amputation?

We retrospectively evaluated the charts of 112 patients with diabetic foot infection to determine if early aggressive surgical intervention improves outcome. All patients were classified into two groups on the basis of the timing of surgical…

Gemifloxacin once daily for 5 days versus 7 days for the treatment of community-acquired pneumonia: a randomized, multicentre, double-blind study.

OBJECTIVES: Short-course therapy has been advocated for the treatment of community-acquired pneumonia (CAP). We compared the efficacy and safety of 5 and 7 day courses of gemifloxacin for outpatient treatment of mild-moderate CAP. PATIENTS AND…

FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia.

OBJECTIVES: Ceftaroline, the active form of the prodrug ceftaroline fosamil, is a novel cephalosporin with bactericidal activity against important pathogens associated with community-acquired pneumonia (CAP), including Streptococcus pneumoniae and…

Tags: 2011, 80 and over, Aged, Bacteria, Bacteria/isolation & purification, Bacterial – Drug Therapy, Bacterial/*drug therapy, Ceftriaxone – Administration and Dosage, Ceftriaxone – Adverse Effects, Ceftriaxone/administration & dosage/adverse effects, Cephalosporins – Administration and Dosage, Cephalosporins – Adverse Effects, Cephalosporins/*administration & dosage/*adverse effects, Community-Acquired Infections – Drug Therapy, Community-Acquired Infections/*drug therapy, Critchley Ian A, Department of Internal Medicine, Double-Blind Method, Double-Blind Studies, Eckburg Paul B, Female, File Thomas M Jr, Friedland H David, Human, Humans, Infusions, Intravenous, Lee Jon, Llorens Lily, Low Donald E, Male, Middle Age, Middle Aged, NEOMED College of Medicine, Pneumonia, RANDOMIZED controlled trials, Talbot George H, The Journal of antimicrobial chemotherapy, Thye Dirk A, Treatment Outcome, Treatment Outcomes

Ceftaroline fosamil versus ceftriaxone for the treatment of community-acquired pneumonia: individual patient data meta-analysis of randomized controlled trials.

BACKGROUND: We conducted a meta-analysis of clinical trials of adults hospitalized with pneumonia outcomes research team (PORT) risk class 3-4 community-acquired pneumonia (CAP) receiving ceftaroline fosamil versus ceftriaxone. METHODS: Three Phase…

A Prospective Observational Study of the Epidemiology, Management, and Outcomes of Skin and Soft Tissue Infections Due to Carbapenem-Resistant Enterobacteriaceae.

BACKGROUND: This study was performed to characterize the epidemiology, management, and outcomes of skin and soft tissue infection (SSTI) and colonization due to carbapenem-resistant Enterobacteriaceae (CRE). METHODS: Patients from the Consortium on…

Carbapenem-Resistant Enterobacteriaceae Infections in Patients on Renal Replacement Therapy.

Background: Patients on chronic intermittent renal replacement therapy (RRT) are at risk for infection with carbapenem-resistant Enterobacteriaceae (CRE). However, the impact of RRT on outcomes after CRE infections remains to be defined. Here we…

Successful Treatment of a Renal Abscess Caused by Mycobacterium chelonae: A Case Report.

Tags: 2018, Department of Internal Medicine, Jabr Ahmad, NEOMED College of Medicine, Open forum infectious diseases, Verghese Elizabeth, Watkins Richard R

The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE)…

Using chart reviews to assess residents' performances of components of physical examinations: a pilot study.

PURPOSE: To evaluate chart review as a method of assessing residents' performances of physical examinations in an ambulatory care setting. METHOD: In 1992, nurse authors at the Affiliated Hospitals at Canton of the Northeastern Ohio Universities…

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