Brittle diabetes is a therapeutic challenge. The first experience with a pocket Insulin Dosage Computer (IDC(TM)) in brittle diabetes was conducted in the form of a clinical N-of-1 trial. After intensified conventional therapy (ICT) the patients used…
Despite the long history of descriptions of reflex sympathetic dystrophy (RSD), much confusion remains regarding its pathogenesis, diagnosis, and treatment. It most commonly occurs after trauma and is more frequent in women, white persons, and the…
A systematic approach to the successful investigation and management of oliguria uses a reproducible method called the Rules of Three: consideration of three sources of olguria (postrenal, prerenal, and renal), three noninvasive tools for evaluation…
Early detection and careful management of kidney disease can help slow or halt progression to renal failure. Early diagnosis is based on a history and physical examination, urinalysis (with dipstick testing for protein, blood, and pH), and…
Calcium pyrophosphate deposition disease (CPPD), a form of crystalline arthritis, has a unique distribution in the Early to Middle Archaic Periods (3000 to 8000 years before the present) of North America, contrasting with the generalized geographic…
Analyses of New World skeletal populations for the presence of erosions an other osseous alterations and their character, distribution, and radiologic appearance shows that osteoarthritis is predominantly a disease of animals raised in artificially…
Identification of a 3100-year-old lithopedion in the Archaic Southwest antedates its first clinical notation by 21 00 years. It was only the ''autopsy'' of time (excavation of the site) that allowed its presence to be brought to light.
Documentation of the antiquity and tracking of the derivation of human treponemal diseases have been complicated by an inability to distinguish among these diseases biochemically, histologically, and immunologically. Skeletal impact, as a population…
Sixty skeletons of Callithrix jacchus were examined to identify spondy-loarthropathy. Erosive disease in Callithrix was confirmed as spondy-loarthropathy on the basis of diagnostic sacroiliac erosions, syndesmophyte formation, and the nature and…
Ischemic nephropathy (IN) is defined as a clinically significant reduction in glomerular filtration rate in patients with hemodynamically significant obstruction to renal artery flow in a solitary functioning kidney or with bilateral renal artery…
Although sarcoidosis has clinical and histopathologic similarities to some forms of tuberculosis and other mycobacterial infections, attempts to establish a mycobacterial etiology have not been successful. Using cytoplasmic antigens derived from a…
Calcified deposits in the tunica media of the human aorta have been studied in 128 cases by light microscopy and by electron microscopy and analytical methods in selected samples. Although dissolved and not visible in routine histology with alum…
THE EDUCATIONAL ROLE OF health sciences librarians in both academic centers and in hospitals is expanding due to influences of new educational models and growing use of technology. Innovative health sciences curricula are being applied in…
OBJECTIVE. Conversion of bone marrow in the extremities from red to yellow is a normal maturation process. Marrow reconversion is present when expected yellow marrow is replaced with active red marrow, and it tends to occur at times of physiologic…
The present study was undertaken to determine whether the diminished cardiac performance associated with cocaine administration persists after the drug has been eliminated from the body. Cocaine (5 or 10 mg/kg iv) was administered to conscious (n =…
Inflammatory polyps are usually associated with inflammatory bowel disease. The majority of these lesions are asymptomatic, however, they may be a source of obstruction or hemorrhage. These polyps represent re-epithelialization of the damaged colonic…
Examining the hemodynamic responses to exercise provides a unique opportunity to analyze and integrate cardiovascular physiology because more is learned about how a system operates when it is forced to perform than when it is idle. We designed a…
The influence of the release of endothelium-derived nitric oxide (NO) on the vasoconstrictor response to phenylephrine (PE) was evaluated before and after a single bout of dynamic exercise. Each rat ran on a motor-driven treadmill at
According to 1992 Cancer Statistics, prostate carcinoma is once again predicted to be the most common cancer in men, exceeding the incidence of lung cancer. In American men, this cancer is estimated to be the second most frequent cause of cancer…
Positive inspiratory pressure- (PIP) ventilated, isolated rat lungs become edematous when perfused at rates approximately the normal cardiac output. The study was conducted to test the hypothesis that high peak inspiratory pressures contribute to the…
From 1972 to 1990, 69 cases of gastroschisis were treated at Akron Children's Hospital Medical Center. Eighty-one percent of these patients underwent primary closure of their abdominal wall defect. Thirteen of 69 patients (19%) required Silastic…
The legal concept of the right of psychiatric patients to treatment in the least restrictive alternative has come to mean treatment anywhere but in the state hospital, as illustrated in two large communities in Ohio and Massachusetts. Oversimplified…
Most practitioners working in community support settings understand the need to provide a comprehensive array of well-coordinated services to individuals with severe mental disabilities. However, a lack of consensus about the conceptual basis of…
The purpose of this study was to evaluate the accuracy of clinical diagnosis of acute pelvic inflammatory disease (PID). Data were obtained on 176 consecutive women admitted to St. Elizabeth Hospital Medical Center with a clinical diagnosis of PID.…
