Browse Items (61 total)
- Tags: Geldenhuys Werner J
Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening.
Tags: 2010, Bioorganic & medicinal chemistry letters, Carroll Richard T, Darvesh Altaf S, Department of Pharmaceutical Sciences, Funk Max O, Geldenhuys Werner J, Models, Molecular, Monoamine Oxidase Inhibitors/chemistry/*pharmacology, Monoamine Oxidase/*drug effects, NEOMED College of Pharmacy, Structure-Activity Relationship, Van der Schyf Cornelis J
Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion.
Tags: 2012, Animals, Corpus Striatum/*drug effects/metabolism, Darvesh Altaf S, Department of Pharmaceutical Sciences, Dluzen Dean E, Dopamine/*metabolism, Drug Synergism, Geldenhuys Werner J, Inbred C57BL, Indoles/*pharmacology, Methamphetamine/*pharmacology, Mice, NEOMED College of Pharmacy, Neurochemistry international
Pharmacotherapy of Alzheimer's disease: current and future trends.
Tags: 2015, Alzheimer Disease/*drug therapy, Alzheimer's disease, Anti-Inflammatory Agents, Antioxidants, cholinesterase inhibitors, Darvesh Altaf S, dementia, Department of Pharmaceutical Sciences, Drug Therapy/*methods/*trends, Expert review of neurotherapeutics, Geldenhuys Werner J, Humans, immunotherapy, memantine, multi-targeted drugs, natural products, NEOMED College of Pharmacy, Pharmacotherapy
Evolution of a Natural Products and Nutraceuticals Course in the Pharmacy Curriculum.
Tags: *Biological Products/therapeutic use, *Clinical Competence, *Dietary Supplements, *Students, 2015, American journal of pharmaceutical education, course curriculum, Cudnik Michelle L, Curriculum/*trends, Darvesh Altaf S, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dietary Supplements, Education, Educational Measurement/methods, Evidence-Based Medicine, Geldenhuys Werner J, herbal products, Humans, Krinsky Daniel L, NEOMED College of Pharmacy, Nutraceuticals, Pharmacy, Pharmacy/methods/*trends
Structure-activity and in vivo evaluation of a novel lipoprotein lipase (LPL) activator.
Tags: *Diabetes, *High-fat diet, *Homology modeling, *Hyperlipidemia, *Lipoprotein lipase, *Liver cirrhosis, *Obesity, 2017, Animals, Benzeneacetamides/chemical synthesis/chemistry/*pharmacology, Bioorganic & medicinal chemistry letters, Caporoso Joel, Darvesh Altaf S, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dose-Response Relationship, Drug, Geldenhuys Werner J, Imidazoles/chemical synthesis/chemistry/*pharmacology, Lee Yoon-Kwang, Leeper Thomas C, Lin Li, Lipoprotein Lipase/*metabolism, Mice, Molecular Docking Simulation, Molecular Structure, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED College of Pharmacy, Sadana Prabodh, Structure-Activity Relationship
Natural products of dietary origin as lead compounds in virtual screening and drug design.
Tags: *Biological Products/pharmacology, *Drug Design, 2012, Animals, Bishayee Anupam, Caffeine/pharmacology, Carroll Richard T, Curcumin/pharmacology, Current pharmaceutical biotechnology, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diet, Geldenhuys Werner J, Genistein/pharmacology, Humans, NEOMED College of Pharmacy, Resveratrol, Stilbenes/pharmacology
Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue.
Tags: 2009, Animals, Bezuidenhout Lois-May, Biological Transport/drug effects, Buffers, Calcium Channels/metabolism, Dluzen Dean E, Dopamine Plasma Membrane Transport Proteins/metabolism, Dopamine Uptake Inhibitors/*pharmacology, Dopamine/*metabolism, European journal of pharmacology, Extracellular Space/*drug effects/*metabolism, Geldenhuys Werner J, In Vitro Techniques, Male, Methamphetamine/pharmacology, Mice, Neostriatum/*cytology/drug effects, PC12 Cells, Perfusion, Potassium Channel Blockers/pharmacology, Potassium Channels, Potassium Chloride/pharmacology, Rats, Voltage-Gated/antagonists & inhibitors
High-content screen using zebrafish (Danio rerio) embryos identifies a novel kinase activator and inhibitor.
Tags: *Cancer, *Compound library, *Kinase, *Notochord, *Phenotypic screen, *Somites, *Zebrafish, 2017, Aljammal Rowaa, Animals, Antineoplastic Agents/chemistry/pharmacology, Antitumor/methods, Benzoic Acid/chemistry/pharmacology, Bergeron Sadie A, Bioorganic & medicinal chemistry letters, Chen Wei-Chi, Death-Associated Protein Kinases/metabolism, Department of Integrative Medical Sciences, Drug Discovery/*methods, Drug Screening Assays, Embryo, Enzyme Activation/drug effects, Enzyme Activators/*chemistry/*pharmacology, Gaasch Briah L, Geldenhuys Werner J, Hazlehurst Lori A, Mullins Jackie E, NEOMED College of Medicine, Neoplasms/drug therapy/enzymology, Nonmammalian/*drug effects/enzymology, Protein Kinase Inhibitors/*chemistry/*pharmacology, Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism, Yun June, Zebrafish Proteins/antagonists & inhibitors/metabolism, Zebrafish/*embryology
MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
Tags: *Aging, *Disease Models, *drug discovery, *mitochondrial dysfunction, *mitoNEET, 2017, ACS chemical neuroscience, Animal, Animals, Benkovic Stanley A, Brown Candice M, Corpus Striatum/*metabolism/*pathology, Crish Samuel D, Darvesh Altaf S, Department of Pharmaceutical Sciences, Geldenhuys Werner J, Inbred C57BL, Iron-Binding Proteins/genetics/*metabolism, Knockout, Lin Li, Male, Membrane Proteins/genetics/*metabolism, Mice, Mitochondria/*metabolism/*pathology, NEOMED College of Pharmacy, Parkinson Disease/*metabolism/pathology, Richardson Jason R, Sullivan Patrick G, Yonutas Heather M
A novel Lipoprotein lipase (LPL) agonist rescues the enzyme from inhibition by angiopoietin-like 4 (ANGPTL4).
Tags: 2014, Angiopoietin-like 4 Protein, Angiopoietins/*metabolism, ANGPTL4, Aring Danielle, Atherosclerosis, Benzamides/pharmacology, Bioorganic & medicinal chemistry letters, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Drug Discovery, Enzyme Activation/*drug effects, Geldenhuys Werner J, High-throughput screen, Homology model, Humans, Ibrolipim, Lipoprotein Lipase/*metabolism, LPL, Molecular Docking Simulation, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, NO-1886, Organophosphorus Compounds/pharmacology, Sadana Prabodh
3-D-QSAR and docking studies on the neuronal choline transporter.
Tags: 2010, Allen David D, Binding Sites, Bioorganic & medicinal chemistry letters, Blood-Brain Barrier/metabolism, Computer Simulation, Geldenhuys Werner J, Lockman Paul R, Membrane Transport Proteins/*chemistry/metabolism, Models, Molecular, Neurons/*metabolism, Quantitative Structure-Activity Relationship, Quaternary Ammonium Compounds/chemistry
Novel models for assessing blood-brain barrier drug permeation.
Tags: *Capillary Permeability, 2012, Allen David D, Animal, Animals, Blood-Brain Barrier/*metabolism, Bloomquist Jeffrey R, Drosophila melanogaster/metabolism, Expert opinion on drug metabolism & toxicology, Geldenhuys Werner J, Grasshoppers/metabolism, High-Throughput Screening Assays, Humans, Models, Pharmaceutical Preparations/*metabolism, Zebrafish/metabolism
The blood-brain barrier choline transporter.
Tags: 2012, Allen David D, Animals, Blood-Brain Barrier/drug effects/*metabolism, Central nervous system agents in medicinal chemistry, Drug Delivery Systems/*methods, Geldenhuys Werner J, Humans, Membrane Transport Proteins/*metabolism, Organic Cation Transport Proteins/metabolism, Organic Cation Transporter 1/metabolism, Organic Cation Transporter 2
Parkinson's disease biomarker: a patent evaluation of WO2013153386.
Tags: 2014, Abdelmagid Samir M, Autophagy, Biomarkers/metabolism, clinical testing, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Disease Progression, Dopaminergic Neurons/pathology, Expert opinion on therapeutic patents, Gallegos Patrick J, Geldenhuys Werner J, Humans, Mitochondria/pathology, mitochondrial membrane potential, mitophagy, NEOMED College of Medicine, NEOMED College of Pharmacy, Parkinson Disease/*diagnosis/physiopathology, Patents as Topic, Phosphorylation, Protein Kinases/*metabolism, Safadi Fayez F, Ubiquitin-Protein Ligases/*metabolism
4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling.
Tags: *4-Hydroxynonenal, *Coronary regulation, *Lipid peroxidation, *Post-translational modification, *Protein Processing, *Reactive oxygen species, *Signal Transduction, *TRPV1, 2016, Action Potentials/drug effects, Aldehydes/antagonists & inhibitors/metabolism/*pharmacology, Animal, Animals, Blood Flow Velocity, Bratz Ian N, Calcium Signaling/drug effects, Cappelli Holly C, Capsaicin/*pharmacology, Cardiovascular Agents/*pharmacology, Connell Patrick J, Coronary Circulation/drug effects, Coronary Vessels/metabolism/physiopathology, Cysteine/genetics/metabolism, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/*metabolism/physiopathology, Disease Models, Fahmy Joseph N, Femoral Artery/metabolism/physiopathology, Free radical biology & medicine, Geldenhuys Werner J, HEK293 Cells, Humans, Inbred C57BL, Lipid Peroxidation, Male, Mice, NEOMED College of Medicine, Patch-Clamp Techniques, Post-Translational, Sinharoy Pritam, Thodeti Charles K, TRPV Cation Channels/genetics/*metabolism, Vasodilation/drug effects
In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery.
Curcumin and neurodegenerative diseases: a perspective.
Tags: 2012, Animals, Bishayee Anupam, Carroll Richard T, Curcumin/adverse effects/pharmacokinetics/*pharmacology/*therapeutic use, Darvesh Altaf S, Department of Pharmaceutical Sciences, Drug Evaluation, Expert opinion on investigational drugs, Geldenhuys Werner J, Humans, NEOMED College of Pharmacy, Neurodegenerative Diseases/*drug therapy/metabolism, Neuroprotective Agents/adverse effects/pharmacokinetics/*pharmacology/*therapeutic use, Novotny Nicholas A, Oxidative Stress/drug effects, Preclinical, Van der Schyf Cornelis J
Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents.
Tags: 2010, Alzheimer Disease/*physiopathology/*therapy, Animals, Antioxidants/*administration & dosage/chemistry/pharmacology, Bishayee Anupam, Carroll Richard T, Darvesh Altaf S, Department of Pharmaceutical Sciences, Expert review of neurotherapeutics, Flavonoids/*administration & dosage/chemistry/pharmacology, Geldenhuys Werner J, Humans, Mitochondria/drug effects/physiology, NEOMED College of Pharmacy, Neurodegenerative Diseases/physiopathology, Oxidative Stress/drug effects/*physiology, Phenols/*administration & dosage/chemistry/pharmacology, Polyphenols, Van der Schyf Cornelis J
Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.
Tags: 2011, Animals, Awale Prabha S, Bioorganic & medicinal chemistry letters, Carroll Richard T, Dluzen Dean E, Funk Max O, Geldenhuys Werner J, Humans, Inbred C57BL, Male, Mice, Models, Molecular, Molecular Structure, Monoamine Oxidase Inhibitors/chemical synthesis/chemistry/*pharmacology, Monoamine Oxidase/*metabolism, Stereoisomerism, Stinnett Hilary, Structure-Activity Relationship, Thiazolidinediones/chemical synthesis/chemistry/*pharmacology
Markers associated with testosterone enhancement of methamphetamine-induced striatal dopaminergic neurotoxicity.
Tags: 2012, Animals, Biomarkers/metabolism, Blotting, Body Temperature/drug effects, Body Weight/drug effects, Buletko A Blake, Corpus Striatum/*drug effects/metabolism, Darvesh Altaf S, Department of Pharmaceutical Sciences, Dluzen Dean E, Dopamine Plasma Membrane Transport Proteins/metabolism, Dopamine/*metabolism, Drug Synergism, Geldenhuys Werner J, HSP70 Heat-Shock Proteins/metabolism, Inbred Strains, Male, McDermott Janet L, Methamphetamine/*toxicity, Mice, NEOMED College of Pharmacy, Neurotoxicity Syndromes/*etiology/metabolism, Neurotoxicology and teratology, Oxidative Stress/drug effects, Testosterone Propionate/*pharmacology, Vesicular Monoamine Transport Proteins/metabolism, Western
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson's disease.
Tags: 2012, Al-Baghdadi Osamah B, Alkaloids/*chemistry/isolation & purification/pharmacology, Animals, Benzodioxoles/*chemistry/isolation & purification/pharmacology, Binding Sites, Bioorganic & medicinal chemistry letters, Blood-Brain Barrier/drug effects, Bovine/metabolism, Cattle, Geldenhuys Werner J, Humans, Hydrogen Bonding, Molecular Docking Simulation, Monoamine Oxidase Inhibitors/*chemistry/isolation & purification/pharmacology, Monoamine Oxidase/*chemistry/metabolism, Parkinson Disease/metabolism/pathology, Piper nigrum/*chemistry, Piperidines/*chemistry/isolation & purification/pharmacology, Polyunsaturated Alkamides/*chemistry/isolation & purification/pharmacology, Prater Natalie I, Protein Binding, Protein Structure, Serum Albumin, Tertiary, Van der Schyf Cornelis J