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Increased chondrocyte apoptosis in growth plates from children with slipped capital femoral epiphysis

Ultrastructural studies of slipped capital femoral epiphysis (SCFE) growth plates have shown diminished cellularity and marked distortion of the architecture in the proliferative and hypertrophic zones. Chondrocyte degeneration and death were noted…

Tags: 2005, Adamczyk M J, Apoptosis, Horton W E, Journal Article or Conference Abstract Publication, Journal of Pediatric Orthopaedics, McBurney D, Nugent A, Orthopedics, Pathogenesis, Pediatrics, programmed cell-death, slipped capital femoral epiphysis, terminal hypertrophic chondrocytes, Weiner D S

Cytometric study of the female Syrian hamster gallbladder epithelium following sex steroid administration.

This report is a cytometric study of the female Syrian hamster gallbladder epithelium following 1-, 2-, and 3-month administration of female sex steroids. Nulliparous, multiparous, young, old and pregnant hamsters were used in this study. A 1 month…

Tags: 1993, Adamiec-Beyga E, Animals, Cell Count, Cholelithiasis/*chemically induced/pathology, Cricetinae, Cytoplasm/drug effects, Drug Administration Schedule, Epithelial Cells, Epithelium/drug effects, Estrogens/*pharmacology, Female, Gallbladder/cytology/*drug effects, Gilloteaux J, Karkare S, Kelly T R, Mesocricetus, Progesterone/*pharmacology, Tissue & cell

A new model for emergency care of geriatric patients

Tags: 2003, Academic Emergency Medicine, Adams J G, Emergency Medicine, Journal Article or Conference Abstract Publication, Lowell W G

Epidemiology of trauma: Childhood adversities, neighborhood problems, discrimination, chronic strains, life events, and daily hassles among people with a severe mental illness

Trauma during childhood and adolescence is a common event among people with a serious psychological disorder. Few studies assess a wide range of stressors for this population. This is surprising given that these stressful events are implicated in…

Childhood Adversity, Proximal Stressors and PTSD Among People with Severe Mental Illness: An Exploratory Study.

The purpose of this exploratory study is to: (1) assess prevalence of childhood adversities and posttraumatic stress disorder (PTSD); (2) assess their association, and; (3) explore whether proximal sources of stress affect this relationship and/or…

Tags: 2020, Adams Richard E, Bonfine Natalie, Childhood adversity, Community mental health journal, Department of Family & Community Medicine, Department of Psychiatry, Journal Article, journalArticle, June 2020 Update I, NEOMED College of Graduate Studies, NEOMED College of Medicine, PTSD, Ritter Christian, Serious mental illness, Stress, trauma

Absence of TRPV4 protects heart from pressure-overload induced injury via inhibition of Rho/MRTF-A mediated cardiac fibrosis

Tags: 2016, Adapala R K, Biochemistry & Molecular Biology, Cappelli H C, Cell Biology, Chilian W M, Faseb Journal, Journal Article or Conference Abstract Publication, Life Sciences & Biomedicine - Other, Lull J, Meszaros J G, Ohanyan V A, Paruchuri S, Thodeti C K, Thoppil R J, Topics

A Novel TRPV4-dependent Mechanotranscription Pathway Regulates Cardiac Fibrosis Following Pressure-Overload

Tags: 2015, Adapala R K, Cappelli H, cardiac fibroblast, Cardiovascular System & Cardiology, Chilian W M, Circulation research, Fibrosis, Hematology, Journal Article or Conference Abstract Publication, Luli J, mechanical signaling, Meszaros J G, myofibroblast, Ohanyan V A, Paruchuri S, Thodeti C, Thoppil R, TRPV4

Absence of TRPV4 Channels Improves Cardiac Function and Remodeling Following Myocardial Infarction and Transverse Aortic Constriction

TRPV4 deletion improves cardiac function, structure and remodeling following myocardial infarction

Tags: 2017, Adapala R K, Biochemistry & Molecular Biology, Cappelli H C, Cell Biology, Faseb Journal, Journal Article or Conference Abstract Publication, Kanugula A K, Life Sciences & Biomedicine - Other, Meszaros J G, Minasyan A, Paruchuri S, Thodeti C K, Topics

Protein Kinase C alpha mediates acetylcholine-induced TRPV4 activation in microvascular endothelial cells

Tags: 2011, Adapala R K, Biochemistry & Molecular Biology, Bratz I N, Cell Biology, Faseb Journal, Journal Article or Conference Abstract Publication, Life Sciences & Biomedicine - Other, Meszaros G, Thalasila P K, Thodeti C K, Topics

Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy.

Tumor vessels are characterized by abnormal morphology and hyperpermeability that together cause inefficient delivery of chemotherapeutic agents. Although vascular endothelial growth factor has been established as a critical regulator of tumor…

TRPV4 Channel Deletion Improves Cardiac Remodeling Following Myocardial Injury via Modulation of MRTF-A Pathway

Tags: 2015, Adapala R K, Biochemistry & Molecular Biology, Cappelli H, Cell Biology, Chilian W, Faseb Journal, Journal Article or Conference Abstract Publication, Life Sciences & Biomedicine - Other, Luli J, Luther D, Meszaros J, Ohanyan V, Paruchuri S, Thodeti C, Thoppil R, Topics

TRPV4 Channel Deletion Improves Cardiac Function and Remodeling Following Myocardial Infarction and Transverse Aortic Constriction via Modulation of Rho/MRTF-A Pathway

Mechanosensitive Trpv4 Channels Mediate Cardiac Myofibroblast Differentitation

Tags: 2011, Adapala R, Cardiovascular System & Cardiology, Chilian W M, Circulation, Extracellular Matrix, Fibrosis, Ion Channels, Journal Article or Conference Abstract Publication, Luther D, Meszaros J G, myocardial infarction, Shah S, Signal Transduction, Thodeti C K

TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation.

Cardiac fibrosis caused by adverse cardiac remodeling following myocardial infarction can eventually lead to heart failure. Although the role of soluble factors such as TGF-beta is well studied in cardiac fibrosis following myocardial injury, the…

PKCalpha mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells.

Transient receptor potential vanilloid channel 4 (TRPV4) is a polymodally activated nonselective cationic channel implicated in the regulation of vasodilation and hypertension. We and others have recently shown that cyclic stretch and shear stress…

Tags: 2011, Acetylcholine/*pharmacology, Adapala Ravi K, American journal of physiology. Heart and circulatory physiology, Animals, Bratz Ian N, Calcium Signaling/*drug effects, Carbazoles/pharmacology, Cells, Cultured, Department of Integrative Medical Sciences, Endothelial Cells/*drug effects/enzymology, Enzyme Activation, Inbred C57BL, Knockout, Male, Mesenteric Arteries/drug effects/enzymology, Meszaros J Gary, Mice, Mutation, NEOMED College of Medicine, Nitric Oxide Synthase Type III/metabolism, Phosphorylation, Protein Kinase C-alpha/genetics/*metabolism, Protein Kinase Inhibitors/pharmacology, Suzuki Makoto, Talasila Phani K, Tetradecanoylphorbol Acetate/pharmacology, Thodeti Charles K, Time Factors, Transfection, TRPV Cation Channels/*agonists/deficiency/genetics/metabolism, Vasodilation/*drug effects, Vasodilator Agents/*pharmacology, Zhang David X

TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals.

The phenotypic switch underlying the differentiation of cardiac fibroblasts into hypersecretory myofibroblasts is critical for cardiac remodeling following myocardial infarction. Myofibroblasts facilitate wound repair in the myocardium by secreting…

Endothelial Trpv4 contributes to pressure overload-induced pathological hypertrophy via modulation of coronary angiogenesis

Tags: 2020, Adapala RK, angiogenesis, Cardiac hypertrophy, Chilian WM, Circulation research, Department of Integrative Medical Sciences, Fibrosis, Ion Channels, January 2021 List, journalArticle, Kanugula AK, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED Student Publications, Ohanyan VA, Paruchuri SM, Thodeti CK

Delirium Precipitated by Polycythaemia.

Delirium is a common and serious problem among acutely unwell persons. Although linked to higher rates of mortality, institutionalization and dementia, it remains under diagnosed. Careful consideration of its phenomenology is warranted to improve…

Tags: delirium, Department of Psychiatry, Ehassan NM, Miquel MAR, NEOMED College of Medicine, polycythaemia, Zaraa AS

ATROPHY AND HISTOENZYMOLOGY OF AMP DEAMINASE IN AGING HAMSTER SKELETAL-MUSCLE

Tags: 1982, Ader M, Biology of the Cell, Cell Biology, Gilloteaux J, Journal Article or Conference Abstract Publication

Comparison of the Wellness of a Medical School to General Student Population

Standard JMS Article Final_9AA_Formatted_FORUPLOAD.pdf

When compared to the general population, healthcare students have been shown to have significantly higher rates of burnout, depression, anxiety, and suicidal ideation. However, there is limited data regarding mental health, access to mental health…

How do different feeding delivery parameters affect swallowing behavior in infant pigs?

Tags: 2021, Adjerid K, Bond LE, Department of Anatomy & Neurobiology, Edmonds CE, German RZ, Gould FDH, Integrative and comparative biology, journalArticle, July 2021 List, Mayerl CJ, NEOMED College of Medicine, NEOMED College of Medicine Postdoc, NEOMED Postdoc Publications, Steer KE

Does birth weight affect neonatal body weight, growth, and physiology in an animal model?

Infant birth weight affects neuromotor and biomechanical swallowing performance in infant pig models. Preterm infants are generally born low birth weight and suffer from delayed development and neuromotor deficits. These deficits include critical …

Does birth weight affect neonatal body weight, growth, and physiology in an animal model?

Birth weight is an important predictor of neuromotor and physiological performance in early perinatal development of mammals [1–4]. Our knowledge of the impact of birth weight on growth and performance falls into two broad categories of research.…

Tags: 2021, BIRTH weight, Body Weight, Infants, milk, swallowing, Swine, Weight Gain

Immunohistochemistry and spinal projections of the reticular formation in the northern leopard frog, Rana pipiens

Over 30 nuclei have been identified in the reticular formation of rats, but only a small number of distinct reticular nuclei have been recognized in frogs. We used immunohistochemistry, retrograde tracing, and cell morphology to identify nuclei…

Immunohistochemical localization of substance P, somatostatin, enkephalin, and serotonin in the spinal cord of the northern leopard frog, Rana pipiens.

Using the indirect antibody peroxidase-antiperoxidase method of Sternberger, we localized substance P (SP), somatostatin (SOM), enkephalin (ENK), and serotonin (5HT, 5-hydroxytryptamine) in the spinal cord of Rana pipiens. This is the first study to…

Tags: 1988, Adli D S, Animals, Cruce W L, Enkephalins/analysis, Ho R H, Immunoenzyme Techniques, Male, Neuropeptides/*analysis, Rana pipiens/anatomy & histology/*metabolism, Rosenthal B M, Serotonin/analysis, Somatostatin/analysis, Spinal Cord/*analysis, Substance P/analysis, The Journal of comparative neurology, Yuen G L

Comment on: The association between bariatric surgery and cataract: a propensity-score-matched cohort study

Tags: 2022

Comment on: Validation of the cumulative deficit theory in bariatric surgery: new bariatric frailty score is associated with non-home discharge, prolonged hospital stay and mortality in the era of fast-track bariatric surgery

Tags: 2022

Comment on: Outcomes of same-day discharge sleeve gastrectomy and Roux-en-Y gastric bypass: a systematic review and meta-analysis

Tags: 2022

Conceptualizations of Mental Disorder at a US Academic Medical Center.

How health care professionals conceptualize mental illness has received relatively little attention in existing literature. This survey explored how health care professionals, academic faculty, and trainees at a US academic medical center …

Tags: 2020, Aftab A, Hospital List, Joshi Y, journalArticle, Sewell D, The Journal of nervous and mental disease

ENDOCRINE STATUS OF RECENTLY ABSTINENT ALCOHOLIC MEN

Tags: 1990, Aftab D, Clinical Research, Jarjoura D, Journal Article or Conference Abstract Publication, Karl R, Levy R P, Pittman R, Research & Experimental Medicine

The pathology of lysosomal storage diseases.

Tags: 1995, Agamanolis D P, Electron, Humans, Lysosomal Storage Diseases/*complications/enzymology/genetics/*pathology, Lysosomes/enzymology, Microscopy, Pathology annual

TUMORS OF SKELETAL-MUSCLE

Tags: 1986, Agamanolis D P, Dasu S, Human Pathology, Journal Article or Conference Abstract Publication, Krill C E, Pathology

ARNOLD CHIARI MALFORMATION - REPORT OF 4 CASES WITH CONTAMINATION OF THE CENTRAL-NERVOUS-SYSTEM BY AMNIOTIC CONTENTS

Tags: 1986, Agamanolis D P, Boeckman C R, Hite S H, Journal Article or Conference Abstract Publication, Neurosciences & Neurology, Platt M S, Surgery, Surgical Neurology

FUSARIUM MENINGOENCEPHALITIS IN A CHILD WITH ACUTE-LEUKEMIA

A 15-year-old boy with acute lymphoblastic leukemia (ALL) developed disseminated fusarium infection with meningoencephalitis following a contaminated skin wound. With antifungal therapy, the cutaneous lesions cleared but central nervous system (CNS)…

Tags: 1991, Acute lymphoblastic leukemia, Agamanolis D P, Dasu S, fungal infections, fusarium, Galloway P G, Halasa B, Infection, Infections, Journal Article or Conference Abstract Publication, Kalwinsky D K, Krill C E, Meningitis, Neuropediatrics, Neurosciences & Neurology, opportunistic, Pediatrics

An Unusual Form of Superficially Disseminated Glioma in Children: Report of 3 Cases

Three children, aged 4, 5, and 9 years, had an insidious onset of ataxia. Magnetic resonance imaging (MRI) showed hydrocephalus and countless foci of high T2 signal coating the cerebellum, basilar cisterns, brainstem, and fourth ventricle. Similar…

Neuropathological findings in West Nile virus encephalitis: A case report

A 67-year-old woman had fever, myalgias, progressive weakness, and respiratory insufficiency. In 9 days, flaccid areflexic quadriparesis and bulbar palsy developed. She died 26 days after the onset of her illness. Serum and cerebrospinal fluid…

Tags: 2003, Agamanolis D P, Annals of Neurology, Caveny E A, fever, Guarner J, Infection, Journal Article or Conference Abstract Publication, Leslie M J, myelitis, Neurosciences & Neurology, New York, outbreak, Pathology, Shieh W J, Zaki S R

CHROMOSOMAL-ABNORMALITIES IN 47 PEDIATRIC BRAIN-TUMORS

The karyotypes of 47 pediatric brain tumors (14 cerebellar pilocytic astrocytomas, six cerebral pilocytic astrocytomas, seven anaplastic astrocytomas and glioblastomas, nine medulloblastomas [PNETs], one cerebral neuroblastoma, four ependymomas, and…

Tags: 1995, Agamanolis D P, Cancer Genetics and Cytogenetics, cytogenetics, Genetics & Heredity, human gliomas, Journal Article or Conference Abstract Publication, Malone A M, oncology

RHIZOMELIC CHONDRODYSPLASIA PUNCTATA - REPORT OF A CASE WITH REVIEW OF THE LITERATURE AND CORRELATION WITH OTHER PEROXISOMAL DISORDERS

A 3-year-old girl with rhizomelic chondrodysplasia punctata (RCDP) had severe micrencephaly but a normal gyral pattern, neuronal density, and cortical cytoarchitecture. The white matter was diffusely decreased in mass but normally myelinated. There…

Tags: 1995, Agamanolis D P, Journal Article or Conference Abstract Publication, Novak R W, Pathology, Pediatric Pathology & Laboratory Medicine, Pediatrics, peroxisomal disorders, plasmalogen, rhizomelic chondrodysplasia, zellweger syndrome

GLYCOGEN ACCUMULATION IN THE CENTRAL NERVOUS-SYSTEM IN THE CEREBRO-HEPATO-RENAL SYNDROME - REPORT OF A CASE WITH ULTRASTRUCTURAL STUDIES

Tags: 1979, Agamanolis D P, Journal Article or Conference Abstract Publication, Journal of the neurological sciences, Neurosciences & Neurology, Patre S

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