A 52-year-old white male presented for evaluation of moderate azotemia (blood urea nitrogen (BUN) 52 mg/dl and creatinine 5.4 mg/dl). Renal history was positive for hypertension (156/100), nocturia, and polyuria. There was a 10-year history of an…
Two groups of rats were trained to discriminate between the stimulus properties of either intraperitoneally administered 10.0 mg/kg cocaine or 60 mg/kg ethanol and its vehicle in a two-lever operant chamber. Once trained, both groups exhibited a…
Objective. To assess feasibility of early discharge of patients after transurethral resection of the prostate (TURP) with an indwelling Foley catheter. Methods. A retrospective study comparing a planned early discharge group and a standard post-TURP…
We determined the time course of changes in extravascular lung water (EVLW) that occur after massive sympathetic activation produced by intracisternal veratrine administration in chloralose-anesthetized dogs. Three groups of dogs were studied. In the…
Inbred mice of both sexes of the CBA/KI, C3H/f/KI, and C57 Black/KI strains were fed seven different commercially-available brands of bee pollen and drinking water ad libitum, starting at young adult age (30-35 days), as the only source of food…
Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive…
The expression of cholesterol 7 alpha-hydroxylase mRNA levels in confluent HepG2 cultures was reduced by tauro- or glyco-conjugates of deoxycholate and chenodeoxycholate, but not by cholate. Ursodeoxycholates, on the other hand, stimulated the mRNA…
Cholesterol 7alpha-hydroxylase, the rate-limiting enzyme in the bile acid synthesis pathway, is down-regulated by taurocholate by way of negative feedback control at the level of gene transcription. The molecular basis of regulation of cholesterol…
In Experiment I, castrated male and female CD-1 mice +/- estradiol benzoate (EB) treatment were tested for their performance on a skilled sensorimotor task consisting of walking across beams of varying widths (6, 9, 12, and 21 mm). To evaluate…
Two models of infant incubators were studied to determine the strength of the magnetic field generated by the heater and fan motors. Measurements were taken at intervals along the center line of the incubator. The results show that fields greater…
The finding of eosinophils in the urine has been suggested to be useful in establishing the diagnosis of acute interstitial nephritis (AIN). The diagnostic accuracy of this test has not yet been defined. It is the purpose of this study to define the…
Cholesterol 7 alpha-hydroxylase (P450c7) is the first and rate-limiting enzyme in bile acid biosynthesis and is the product of a cytochrome P450 gene, CYP7. We have previously reported the cloning of a full-length human cholesterol 7…
The factor structure of the Family-of-Origin Scale (FOS) was examined. The FOS is a 40-item instrument devised to measure perceptions of health in the family of origin. Subjects were 162 gay and bisexual males. A confirmatory factor analysis was…
Far-advanced otosclerosis (FAO) is an uncommon diagnosis. Hearing levels in patients with FAO may range from profound loss, by air conduction and fragmentary bone conduction thresholds, to no measurable air or bone conduction thresholds. Thus, FAO…
BACKGROUND: One response to the decline in interest among medical students in residency training in primary care has been the offering, by residency programs and hospitals, of financial recruitment incentives to medical students during their…
A peculiar hyaline sarcoplasmic inclusion in the atrial myocytes of old female Syrian hamsters is described. This type of inclusion resembles that described in rare human cardiomyopathy. They have also been described in other rodents and have been…
Forefoot pain in the athlete is common. Generally, the symptoms are a result of overuse. The initial treatment strategy is to modify both exercise and shoewear. Specific diagnoses of the problem is key to proper treatment. Usually, the history and…
Recent members of the order Cetacea (whales, dolphins, and porpoises) move in the water by vertical tail beats and cannot locomote on land. Their hindlimbs are not visible externally and the bones are reduced to one or a few splints that commonly…
We tested the hypothesis that reflex responses to mechanical [increase in left atrial pressure (LAP) 0-25 mmHg] and chemical stimulation [left atrial injection of phenylbiguanide (PBG), 0.5-10 mg/kg] of cardiopulmonary receptors are greater in female…
Few reports in gynecologic literature have addressed patient preferences about terminal care. In light of the current discussions about end-of-life decision-making, a study was designed to assess the desires of patients with gynecologic cancer. A…
The genetically obese Zucker rat is a widely used model of early-onset obesity. Like obese children, these obese rats are hyperinsulinemic and have low GH secretion. However, data on linear growth and insulin-like growth factor-I (IGF-I) levels in…
Hyperemesis gravidarum is not an uncommon condition in the first trimester of pregnancy. In some of these patients, the condition is so severe that it causes the development of dehydration and electrolyte imbalances. When that happens, the patient…
Four cases histories illustrate the process of defining the cause of hyponatremia: Categorize the patient's volume status; determine kidney function and kidney's response to volume stimulus; measure urine osmolality; consider other factors, including…
Abnormalities that increase water reabsorption can lead to hyponatremia, and the resulting water retention presents the threat of CNS volume changes. Avoid overcorrection of hyponatremia, however, as this causes similar changes. Also, be aware of…
Nucleotide sequences of a 7997-base pair SacI fragment spanning 3643 base pairs of the upstream promoter region to exon 4 of the rat cholesterol 7 alpha-hydroxylase gene (CYP7) have been determined. DNase I footprinting and electrophoretic mobility…
