Objective: Allergic sensitization is very prevalent and often precedes the development of allergic disease. This study examined the association of race with allergic sensitization among healthy children with no family history of atopy.Study Design:…
UNLABELLED: Bile acid synthesis in the liver is regulated by the rate-limiting enzyme cholesterol 7alpha-hydroxylase (CYP7A1). Transcription of the CYP7A1 gene is inhibited by bile acids and cytokines. The rate of bile acid synthesis is reduced…
The dietary supplements androstenedione, dehydroepiandrosterone, and androstenediol are precursors in the endogenous production of testosterone. The efficacy and safety of these prohormones are not well established but are promoted to have the same…
The dietary supplements androstenedione, dehydroepiandrosterone, and androstenediol are precursors in the endogenous production of testosterone. The efficacy and safety of these prohormones are not well established but are promoted to have the same…
An overlapping binding site in the CYP7A1 promoter allows activation of FXR to override the stimulation by LXR alpha. Am J Physiol Gastrointest Liver Physiol 293: G817-G823, 2007. First published August 9, 2007; doi:10.1152/ajpgi.00209.2007.-The aim…
Growth hormone is known to stimulate connective tissue, but the degree to which it influences skin biomechanical properties is unclear. This study tested the hypothesis that human growth hormone transgene expression changes the material properties…
The proximal and distal growth plates of the principal long bones do not contribute equally to longitudinal growth. Most forelimb elongation occurs at the shoulder and wrist, while most hindlimb growth occurs at the knee. This study examined whether…
A common method for identifying collateral projections is to inject different retrograde tracers into two targets and examine labeled cells for the presence of both tracers. Double-labeled cells are considered to have collateral projections to the…
Posterior glenohumeral dislocations are rare, and an accurate diagnosis is often difficult to make. Although rotator cuff tears are a known risk in the common traumatic anterior glenohumeral dislocation, they are an extremely rare event in…
The use of fresh-frozen osteochondral allografts has been reported for the treatment of talar fractures, osteochondral lesions, and tumors of the calcaneus. Currently, we are unaware of any reports in the literature addressing the use of fresh-frozen…
The medial and lateral menisci play important roles in knee biomechanics, kinematics, and stability. Unfortunately, these structures are prone to damage and, because of a tenuous blood supply, have great difficulty healing. Many interventions have…
Gene expression levels for type II collagen and aggrecan have been determined as potential measures and disease markers of human osteoarthritis in patients undergoing total knee arthroplasty. In this regard, specimens of affected articular cartilage…
Purpose of review: The studies, reviewed in this article suggest that a shorter duration of antibiotic therapy is comparable to standard therapy in the treatment of community-acquired pneumonia and promotes reduction of adverse events, microbial…
The SWOT analyses presented by the authors in this special issue on International Perspectives on Counseling Psychology propose numerous possibilities for building a strategic plan for the new Counseling Psychology Division (16) in the International…
Although NMDA receptors (NMDARs) are associated with synaptic plasticity, they form an essential part of responses to sensory stimuli. We compared contributions of glutamatergic NMDARs and AMPA receptors (AMPARs) to auditory responses in the inferior…
We have observed that hydrogen peroxide (H2O2), the dismutated product of superoxide, is a coronary metabolic dilator and couples myocardial oxygen consumption to coronary blood flow. Because the chemical activity of H2O2 favors its role as an…
Calcium pyrophosphate deposition (CPPD) disease is confirmed as equally common in rheumatoid arthritis by synovial fluid and macroscopic skeletal examination. Furthermore, differential frequencies in rheumatoid arthritis and spondyloarthropathy…
This systematic survey of museum ratite (Pterocnemia, Rhea, Casuarius, Struthio, Dromias and Apteryx) skeletal collections was performed to reevaluate previous perspectives and assess effect of captivity on macroscopically detectable pathology.…
OBJECTIVES: This study was performed to assess osseous contributions to osteoarthritis, obviating the analysis challenges presented by confounding factors in humans and rarity of osteoarthritis in free-ranging mammals. METHODS: Frequency of…
Reactive oxygen species (ROS) are implicated in coronary collateral growth (CCG). We evaluated the requirement for ROS in human coronary artery endothelial cell (HCAEC) tube formation, CCG in vivo, and signaling (p38 MAP kinase) by which ROS may…
Mammalian metapodials (metacarpals and metatarsals), unlike most long bones, form a single growth plate, and undergo longitudinal growth at only one end. The growth dynamics of non-mammalian tetrapod metapodials have not been systematically examined…
PURPOSE OF REVIEW: Nutrition plays a significant role in the pathogenesis and treatment of the two major forms of inflammatory bowel disease: Crohn's disease and ulcerative colitis. In addition, patients with inflammatory bowel disease are often…
PURPOSE OF REVIEW: Nutrition plays a significant role in the pathogenesis and treatment of the two major forms of inflammatory bowel disease: Crohn's disease and ulcerative colitis. In addition, patients with inflammatory bowel disease are often…
Objective: Determine chief residents' experience with vacuum and forceps deliveries and self-perceived competencies with the procedures. Study Design: Study 1: A written questionnaire was mailed to all fourth year residents in US RRC approved Ob/Gyn…
Transference is a key concept in psychoanalysis, distinguishing the analytic treatment from other forms of psychotherapy. In this essay, the authors place transference into the context of a general psychology of human functioning and link it to the…
The superior olivary complex (SOC) and inferior colliculus (IC) are targets of cortical projections as well as sources of major ascending auditory pathways. This study examines whether the cortical projections contact cells in the SOC or IC that…
We describe the prenatal diagnosis of partial anomalous pulmonary venous connection (PAPVC) at 27 weeks' gestation in a patient with Fryns with the right upper pulmonary vein to the right superior vena cava and right atrial junction. The remaining…
Isolation of the subclavian artery is an uncommon anomaly of the aortic arch system in which one subclavian artery loses its connection with the aorta and arises from the homolateral pulmonary artery by way of a ductus arteriosus. An isolated…
An aortopulmonary septal defect is a rare cardiac malformation in which there is a communication between the ascending aorta and pulmonary trunk in the presence of 2 separate semilunar valves. There are reports of postnatal diagnosis of…
Tetralogy of Fallot is known to be associated with anomalies in the origin or course of coronary arteries. We describe a case of fetal echocardiographic diagnosis at 24 weeks' gestation of tetralogy of Fallot with a single right coronary artery in…
BACKGROUND: Appendicitis in elderly patients is associated with significant morbidity and mortality. Early and correct diagnosis together with minimally invasive surgery can lead to more favorable outcomes than occurred in the prelaparoscopic era.…
