Browse Items · NEOMED Bibliography Database

Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.

BACKGROUND: Lefamulin, a pleuromutilin antibiotic, is active against pathogens commonly causing community-acquired bacterial pneumonia (CABP). The Lefamulin Evaluation Against Pneumonia (LEAP 1) study was a global noninferiority trial to evaluate…

Tags: 2019, Administration Intravenous, Adult, Aged, Anti-Bacterial Agents/administration & dosage/adverse effects/therapeutic use, antibiotic, Clinical Infectious Diseases, Das A, Diterpenes/administration & dosage/adverse effects/therapeutic use, Double-Blind Method, Female, File TM, Gasink LB, Gelone SP, Goldberg L, Hospital List, Humans, journalArticle, lefamulin, Linezolid/adverse effects/therapeutic use, Male, Microbial Sensitivity Tests, Middle Aged, Moxifloxacin, Moxifloxacin/administration & dosage/adverse effects/therapeutic use, Paukner S, pleuromutilin, Pneumonia, Pneumonia Bacterial/drug therapy/metabolism, Polycyclic Compounds/administration & dosage/adverse effects/therapeutic use, Randomized Controlled Trials as Topic, Saviski J, Seltzer E, Sweeney C, Talbot GH, Thioglycolates/administration & dosage/adverse effects/therapeutic use, Wicha WW

Pre-pharyngeal Swallow Effects of Recurrent Laryngeal Nerve Lesion on Bolus Shape and Airway Protection in an Infant Pig Model.

Recurrent laryngeal nerve (RLN) damage in infants leads to increased dysphagia and aspiration pneumonia. Recent work has shown that intraoral transport and swallow kinematics change following RLN lesion, suggesting potential changes in bolus…

LVC Timing in Infant Pig Swallowing and the Effect of Safe Swallowing.

Recurrent laryngeal nerve (RLN) injury in neonates, a complication of head and neck surgeries, leads to increased aspiration risk and swallowing dysfunction. The severity of resulting sequelae range from morbidity, such as aspiration pneumonia, to…

Spectrum of excess mortality due to carbapenem-resistant Klebsiella pneumoniae infections.

Patients infected or colonized with carbapenem-resistant Klebsiella pneumoniae (CRKp) are often chronically and acutely ill, which results in substantial mortality unrelated to infection. Therefore, estimating excess mortality due to CRKp infections…

Tags: *beta-Lactam Resistance, 2016, 80 and over, Aged, Bacteremia/microbiology/mortality, Bacterial/microbiology/mortality, Bonomo R A, carbapenem-resistant Enterobacteriaceae, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Cober E, Department of Internal Medicine, Doi Y, Epidemiology, Evans S, Female, Fowler V G Jr, Hauck C, Humans, Kalayjian R C, Kaye K S, Klebsiella Infections/*microbiology/*mortality, Klebsiella pneumoniae, Klebsiella pneumoniae/*drug effects/isolation & purification, Longitudinal Studies, Male, Middle Aged, Mortality, NEOMED College of Medicine, Perez F, Pneumonia, Prospective Studies, Richter S S, Salata R A, Scalera N M, Survival Analysis, Urinary Tract Infections/microbiology/mortality, van Duin D, Watkins R R

Expanded Analysis of 20 Pneumococcal Serotypes Associated With Radiographically Confirmed Community-Acquired Pneumonia in Hospitalized US Adults.

Streptococcus pneumoniae is a causative agent of community-acquired pneumonia (CAP). The 13-valent pneumococcal conjugate vaccine (PCV13) has significantly decreased the burden of PCV13-serotype pneumococcal disease; however, disease from nonvaccine…

Tags: 20-valent pneumococcal conjugate vaccine, 2021, Adult, Pneumonia, serotypes, urinary antigen detection

Expanded Analysis of 20 Pneumococcal Serotypes Associated With Radiographically Confirmed Community-Acquired Pneumonia in Hospitalized US Adults.

Background: Streptococcus pneumoniae is a causative agent of community-acquired pneumonia (CAP). The 13-valent pneumococcal conjugate vaccine (PCV13) has significantly decreased the burden of PCV13-serotype pneumococcal disease; however, disease due…

Pneumococcal epidemiology among us adults hospitalized for community-acquired pneumonia

BACKGROUND: Few studies have measured the burden of adult pneumococcal disease after the introduction of 13-valent pneumococcal conjugate vaccine (PCV13) into the US infant vaccination schedule. Further, most data regarding pneumococcal serotypes are…

Comparison of narrow-versus broad-spectrum antibiotics in elderly patients with acute exacerbations of chronic obstructive pulmonary disease

Background Little evidence is available regarding the choice of empiric antibiotic therapy in elderly patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). The primary objective of this study is to compare the outcomes…

Assessment of time to clinical response, a proxy for discharge readiness, among hospitalized patients with community-acquired pneumonia who received either ceftaroline fosamil or ceftriaxone in two phase III FOCUS trials.

The primary driver of health care costs for patients with community-acquired pneumonia (CAP) is the hospital length of stay (LOS). Unfortunately, hospital LOS comparisons are difficult to make from phase III CAP trials because of their structured…

Bacterial Pneumonia in Older Adults.

Community-acquired pneumonia is common in the elderly person; its presentation in this population is often confounded by multiple comorbid illnesses, including those that result in confusion. Although severity-of-illness scoring systems might aid…

Pediatric airway management in COVID-19 patients: consensus guidelines from the society for pediatric anesthesia's pediatric difficult intubation collaborative and the Canadian Pediatric Anesthesia Society.

The severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019 [COVID-19]) pandemic has challenged medical systems and clinicians globally to unforeseen levels. Rapid spread of COVID-19 has forced clinicians to care for patients with a…

Tags: 2020, Adolescent, Airway Management/ methods, Anesthesia and Analgesia, Anesthesia/methods, Anesthesiology/ methods/standards, Asaf S, Ayad I, Bhalla T, Castro P, Chiao F, Child, Consensus, Coronavirus Infections/ therapy, Crockett C, Dalesio N, Denning S, Department of General Surgery, Disma N, Engelhardt T, Evans F, Fiadjoe JE, Galvez I, Gálvez J, Garcia-Marcinkiewicz A, Glover C, Gooden C, Greenberg R, Greenwood E, Guidelines as Topic, Gumaney H, Haydar B, Hervías M, Hsu G, Humans, Hunyady A, Infant, Infection Control, Infectious Disease Transmission, Ingelmo P, Intratracheal/ methods/standards, Intubation, Jagannathan N, Javia L, journalArticle, July 2020 List, Kiss EE, Kovatsis PG, Lardner D, Lau J, Lee JK, Lee LK, Lockman JL, Matava CT, Matuszczak M, McCloskey J, Mireles S, NEOMED College of Medicine, Newborn, Olomu P, Pandemics, Park R, Patient-to-Professional/prevention & control, Pediatrics/ methods/standards, Pérez-Pradilla C, Peyton J, Pneumonia, Polaner D, Preschool, Raman VT, Rehman M, Reynolds P, Sabato S, Stein ML, Szmuk P, Szolnoki J, Taicher B, Tan J, Templeton T, Theroux MC, Thompson N, Viral/ therapy, Von Ungern-Sternberg B, Whyte S, Yaster M, Yu J

Epidemiology, microbiology, and treatment considerations for bacterial pneumonia complicating influenza

Post-influenza bacterial pneumonia is a major cause of morbidity and mortality associated with both seasonal and pandemic influenza virus illness. However, despite much interest in influenza and its complications in recent years, good clinical trial…

The relationship between psychiatric medication and course of hospital stay among intoxicated trauma patients

Introduction The purpose of this study was to determine whether trauma patients requiring psychiatric medication who were admitted with positive alcohol or drug screen require more pain medications or sedation resulting in longer length of stay.…

Aspiration pneumonia, necrotizing pneumonia, and lung abscess.

Suppurative complications to aspiration pneumonia occur if the initial aspiration and subsequent pneumonitis go unrecognized or untreated. Anaerobic cavitary disease is typically an indolent process, whereas necrotizing pneumonia is more fulminant…

Tags: 1989, Aspiration/diagnosis/*pathology/physiopathology/therapy, Combined Modality Therapy, Department of Internal Medicine, Emergency medicine clinics of North America, Humans, Lung Abscess/diagnosis/etiology/*therapy, Necrosis, NEOMED College of Medicine, Pennza P T, Pneumonia

Treatment of community-acquired pneumonia in immunocompromised adults: A consensus statement regarding initial strategies

Background Community-acquired pneumonia (CAP) guidelines have improved the treatment and outcomes of patients with CAP, primarily by standardization of initial empirical therapy. But current society-published guidelines exclude immunocompromised…

Higher Pneumococcal Disease Vaccination Rates Needed to Protect More At-Risk US Adults

Pneumococcal disease, which includes pneumococcal pneumonia, meningitis, and bacteremia, is associated with substantial morbidity, mortality, and health care costs in adults. Advanced age, chronic lung or cardiovascular disease, immunosuppressive…

Identifying Barriers to Adult Pneumococcal Vaccination: An NFID Task Force Meeting

Pneumococcal infection is common in adults, and invasive disease is associated with a high mortality rate. Pneumococcal polysaccharide vaccine can prevent invasive pneumococcal disease and is recommended for people aged >= 65 years and for younger…

Tags: 2012, adult vaccination, care, Disease, File T M, General & Internal Medicine, Influenza, Journal Article, Metersky M, Natl Fdn Infect Dis Pneumococcal D, Nichol K L, pneumococcal disease, Pneumococcal Vaccine, Pneumonia, Postgraduate medicine, Rehm S J, Schaffner W, Streptococcus pneumoniae, united-states

Managing patients with recurrent acute exacerbations of chronic bronchitis: a common clinical problem

Chronic obstructive pulmonary disease (COPD) affects 15 million people and is the fourth leading cause of death in the United States. It places a considerable burden on the healthcare system, with exacerbations contributing to a significant…

Ceftaroline fosamil versus ceftriaxone for the treatment of community-acquired pneumonia: individual patient data meta-analysis of randomized controlled trials.

BACKGROUND: We conducted a meta-analysis of clinical trials of adults hospitalized with pneumonia outcomes research team (PORT) risk class 3-4 community-acquired pneumonia (CAP) receiving ceftaroline fosamil versus ceftriaxone. METHODS: Three Phase…

Role of 'atypical' pneumonia pathogens in respiratory tract infections.

The 'atypical' pathogens are important causes of pneumonia, causing illness ranging from mild to life-threatening. The most common atypical pathogens are Mycoplasma pneumoniae and Chlamydia pneumoniae; others include Legionella species, Chlamydia…

Tags: 1999, Bacterial/diagnosis/*microbiology, Canadian respiratory journal, Chlamydia Infections, Chlamydophila pneumoniae, Community-Acquired Infections, Humans, Immunoenzyme Techniques, Legionella pneumophila, Mycoplasma/diagnosis/*microbiology, Pneumonia, Polymerase Chain Reaction, Tan J S

Ambulatory management of lower respiratory tract infections.

Clinical manifestations and radiographic findings are unreliable guides to the selection of antimicrobial therapy for lower respiratory infections. Laboratory evaluation is necessary to identify the etiologic agent. Multiple oral antibiotics are…

Tags: 1991, American family physician, Anti-Bacterial Agents/*therapeutic use, Bacterial Infections/drug therapy, Department of Internal Medicine, File T M Jr, Humans, Legionnaires' Disease/diagnosis, Mycoplasma/diagnosis, NEOMED College of Medicine, Pneumonia, Pneumonia/*diagnosis/*drug therapy, Tan J S, Thomson R B Jr

Management of community-acquired pneumonia: a focus on conversion from hospital to the ambulatory setting.

Patients with community-acquired pneumonia (CAP) are treated in hospital or in the ambulatory care setting depending on the severity of illness. Despite numerous guidelines proposed, there is no agreement on specific criteria for hospitalization…

Tags: *Ambulatory Care, *Hospitalization, 2003, American journal of respiratory medicine : drugs, devices, and other interventions, Anti-Bacterial Agents/*administration & dosage, Bacterial/*therapy, Community-Acquired Infections/therapy, Department of Internal Medicine, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumonia, Tan James S

Respiratory infections unique to Asia

Asia is a highly heterogeneous region with vastly different cultures, social constitutions and populations affected by a wide spectrum of respiratory diseases caused by tropical pathogens. Asian patients with community-acquired pneumonia differ from…

Subglottic Secretion Suctioning Reduces Vent-Associated Pneumonia, Antibiotic Use.

Tags: 2014, Academic Medical Centers, Antibiotics, Belgium, Confidence Intervals, Department of Internal Medicine, Endotracheal – Utilization, Human, Infectious Disease Alert, NEOMED College of Medicine, Odds Ratio, Pneumonia, RANDOMIZED controlled trials, Secretions, Suctioning, Ventilator-Associated – Prevention and Control, Watkins Richard R

Omadacycline: A novel tetracycline derivative with oral and intravenous formulations.

Omadacycline, an aminomethylcycline, is a novel member of the tetracycline class of antibiotics. It has received approval by the U.S. Food and Drug Administration (FDA) for treatment of community-acquired bacterial pneumonia (CABP) and acute…

Tags: 2019, ABSSSI, antibiotic, Antimicrobial resistance, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Department of Internal Medicine, Deresinski Stan, NEOMED College of Medicine, omadacycline, Pneumonia, Watkins Richard R

An update on the association of vitamin D deficiency with common infectious diseases.

Vitamin D plays an important role in modulating the immune response to infections. Deficiency of vitamin D is a common condition, affecting both the general population and patients in health care facilities. Over the last decade, an increasing body…

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