Browse Items · NEOMED Bibliography Database

Age-related changes in monoamines within the olfactory bulbs of the Fischer 344 male rat.

In this report the olfactory bulbs (OB) were removed from 5-6 month, 15-16 month and 25-26 month male Fischer 344 rats and assayed for concentrations of monoamines and their metabolites using HPLC-EC. Concentrations of norepinephrine were…

Tags: 1996, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Aging/*metabolism, Animals, Biogenic Monoamines/*metabolism, Dluzen D E, Dopamine/metabolism, Inbred F344, Male, Mechanisms of ageing and development, Olfactory Bulb/*metabolism, Rats, Serotonin/metabolism

Serotonin contributes to the spinal antinociceptive effects of morphine.

This study was designed to determine if morphine administered intrathecally (IT) interacts with serotonergic or noradrenergic nerve terminals in the spinal cord to produce analgesia on the spinally mediated tail-flick test. Male Sprague-Dawley rats…

Lack of neuroleptic-like activity of l-fenfluramine.

Rats were trained to differentiate between the dopaminergically mediated discriminative stimuli produced by intraperitoneal administration of 4.8 mg/kg cathine and its vehicle. Once trained, three doses of l-fenfluramine (1.0, 2.0 and 2.5 mg/kg) were…

Tags: 1991, Animals, Antipsychotic Agents/*pharmacology, Cues, Discrimination (Psychology)/drug effects, Dopamine Agents/pharmacology, Dopamine Antagonists, Fenfluramine/*pharmacology, Inbred Strains, Male, Pharmacology, biochemistry, and behavior, Phenylpropanolamine/pharmacology, Rats, Schechter M D

Conditioned place aversion following the central administration of a novel dopamine release inhibitor CGS 10746B.

Numerous drugs of abuse that elevate brain extracellular dopamine concentrations by either increasing the firing rate of dopaminergic neurons or producing dopamine release have been shown to reliably condition a preference for place. If dopamine…

Tags: 1991, Animals, Antipsychotic Agents/administration & dosage/*pharmacology, Avoidance Learning/*drug effects, Calcagnetti D J, Dopamine/*metabolism, Inbred Strains, Injections, Intraventricular, Male, Motor Activity/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/administration & dosage/*pharmacology

Direct microinjection of cathinone into the rat brain produces discriminative stimuli.

Rats were trained to discriminate IP administration of 800 micrograms/kg cathinone using a food-motivated, two-lever discrimination procedure. Following training, 800 micrograms/kg cathinone discrimination was produced (generalized) by lower…

Effect of altering dopamine or serotonin neurotransmitters upon cathinone discrimination.

Rats were trained to discriminate between the stimulus properties of 0.8 mg/kg l-cathinone and its vehicle in a two-lever, food-motivated operant task. Once trained, rats showed a dose-related decrease in discriminative performance when tested with…

Further evidence for the mechanisms that may mediate nicotine discrimination.

Rats were trained to discriminate the interoceptive stimuli produced by subcutaneously administered 0.4 mg/kg nicotine in a two-lever, food-motivated, operant task. Once criterion performance was attained, dose-response experiments indicated an ED50…

Tags: 1992, Animals, Calcium Channel Blockers/pharmacology, Dihydropyridines/pharmacology, Discrimination Learning, Dopamine/*metabolism, Dose-Response Relationship, Drug, Inbred Strains, Indoles/pharmacology, Isradipine, Male, Meehan S M, Nicotine/administration & dosage/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/pharmacology, Tropisetron

Rats bred for differences in preference to cocaine: other behavioral measurements.

Cocaine has repeatedly been shown to produce conditioned place preference (CPP) in the rat. The present study employed the heterogenous N/Nih rat stock to produce a selectively bred rat line determined by individual place preference to a conditioning…

Tags: 1992, Animal/*drug effects, Animals, Behavior, Choice Behavior/*drug effects, Cocaine/*pharmacology, Dose-Response Relationship, Drug, Female, Inbred Strains, Male, Motor Activity/drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Species Specificity, Sprague-Dawley

Psychostimulant-induced activity is attenuated by two putative dopamine release inhibitors.

Centrally administered amphetamine (AMPH), cathinone, (CATH), or cocaine (COC) have each been shown to produce elevated activity in rats and this effect is dose responsive. The question remains whether these psychostimulants share a common mechanism…

Biphasic effects of ethanol tested with drug discrimination in HAD and LAD rats.

Seventh-generation selectively bred high-alcohol-drinking (HAD) and low-alcohol-drinking (LAD) rats were trained to make differential responses for ethanol (0.75 g/kg, IP) and saline vehicle, following postadministration intervals (PI) of 2 min…

Tags: 1992, Alcohol Drinking/genetics/*psychology, Animals, Discrimination (Psychology)/*drug effects, Discrimination Learning/drug effects, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Inbred Strains, Krimmer E C, Male, Pentobarbital/pharmacology, Pharmacology, biochemistry, and behavior, Rats, Serotonin Antagonists/pharmacology, Sleep/drug effects, Time Factors, Tropanes/pharmacology

Evidence for noradrenergic involvement in mediating the FG 7142 discriminative stimulus.

Rats were trained to discriminate the stimulus properties of the benzodiazepine receptor partial inverse agonist beta-carboline-3-carboxylate acid methyl amide (FG 7142) (5.0 mg/kg) or the alpha 2-adrenergic receptor antagonist 17…

Differential effects of nicotine but not cathinone on motor activity of P and NP rats.

The locomotor stimulatory effects of nicotine (0.4 and 0.8 mg/kg) and cathinone (0.5 and 1.0 mg/kg) were assessed in alcohol-preferring (P) and -nonpreferring (NP) rats. Whereas P rats demonstrated enhanced (0.8 mg/kg) or no change (0.4 mg/kg) in…

Tags: 1993, Alcohol Drinking/*psychology, Alkaloids/*pharmacology, Animals, Dextroamphetamine/pharmacology, Discrimination (Psychology)/drug effects, Genotype, Gordon T L, Male, Meehan S M, Motor Activity/*drug effects, Nicotine/*pharmacology, Pharmacology, biochemistry, and behavior, Psychotropic Drugs/*pharmacology, Rats, Schechter M D

Cocaine discrimination is attenuated by isradipine and CGS 10746B.

The discriminative stimulus properties of cocaine are thought to be mediated by dopaminergic mechanisms that may be modulated by calcium ion influx and/or interact with 5-hydroxytryptamine3 (5-HT3) receptors. To test these possibilities, rats were…

P and NP rats respond differently to the discriminative stimulus effects of nicotine.

Rats selectively bred for ethanol preference, that is, alcohol-preferring (P) and -nonpreferring (NP) rats, were trained to discriminate the interoceptive stimuli produced by IP-administered 1,000 mg/kg ethanol (10% v/v) in a two-lever,…

Tags: 1993, Alcoholism/genetics, Animals, Behavioral, Discrimination Learning/*drug effects/physiology, Drug Tolerance/genetics, Ethanol/administration & dosage/*pharmacology, Genetics, Gordon T L, Male, Meehan S M, Nicotine/administration & dosage/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Schechter M D

Discriminative stimulus properties of isradipine: effect of other calcium channel blockers.

This study constitutes the first report of a calcium channel blocker used as a drug capable of controlling differential responding in a drug-discrimination paradigm. Male Sprague-Dawley rats were trained to discriminate between intraperitoneally…

Tags: 1995, Animals, Calcium Channel Blockers/*pharmacology, Conditioning, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Generalization, Isradipine/*pharmacology, Male, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Sprague-Dawley, Stimulus/*drug effects

Cocaethylene produces discriminative stimulus properties in the rat: effect of cocaine and ethanol coadministration.

Experimentally naive Sprague-Dawley male rats were trained to discriminate the interoceptive stimulus cues produced by either 10.0 mg/kg cocaine or 10.0 mg/kg cocaethylene from their saline vehicles. Although it required more sessions to train the…

Tags: 1995, Animals, Cocaine/*analogs & derivatives/pharmacokinetics/*pharmacology, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Ethanol/pharmacokinetics/*pharmacology, Male, Pharmacology, biochemistry, and behavior, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley

L-dopa reverses castration-induced disruption of dishabituation responses to female chemical cues in male rats.

In the present experiment, habituation/dishabituation behavioral tests were conducted to measure discriminatory olfactory recognition responses to chemical cues among control, castrated, and castrated+L-3,4-dihydroxyphenylalanine (L-DOPA)-treated…

Cocaethylene produces conditioned place preference in rats.

The ability of cocaethylene to produce either a conditioned place preference or a conditioned place aversion was tested in rats. Twelve male rats were administered 10 mg/kg cocaethylene and confined to their nonpreferred side of the conditioned place…

Tags: 1995, Animals, Avoidance Learning/drug effects, Cocaine/*analogs & derivatives/pharmacology, Conditioning, Discrimination (Psychology)/drug effects, Male, Motor Activity/*drug effects, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Sprague-Dawley

A system for measuring electrophysiological multiple unit activity and extracellular dopamine concentration at single electrodes.

A technique is described for measuring electrophysiological multiple-unit activity and extracellular dopamine concentration with in vivo voltammetry at an array of 8 electrodes. In addition, new procedures in the construction of the voltammetric…

Striatal dopamine release in vitro from immature male rats shows enhanced responsiveness to pulsatile, but not continuous, infusions of L-dopa.

In the present experiment we compared the effects of continuous versus pulsed infusions of L-beta-3,4,dihydroxyphenylalanine (L-DOPA) upon dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro from superfused corpus striatal tissue…

Tags: 1991, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Aging/*metabolism, Animals, Brain research. Developmental brain research, Corpus Striatum/*metabolism, Dluzen D, Dopamine/*metabolism, Inbred Strains, Levodopa/*administration & dosage/pharmacology, Male, McDermott J, Pulsatile Flow, Rats

The development of GABAB-mediated activity in the rat dentate gyrus.

We examined the effects of GABAB receptor activation in the dentate gyrus of hippocampal slices prepared from 6-8-day-old rat pup. Baclofen (0.25-1.0 microM), a GABAB agonist, rapidly and potently disinhibited the developing dentate, similar to its…

Tags: 1994, Animals, Baclofen/analogs & derivatives/pharmacology, Brain research. Developmental brain research, DiScenna P G, Electric Stimulation, Evoked Potentials/drug effects, GABA-A Receptor Antagonists, GABA-A/drug effects/physiology, GABA-B Receptor Antagonists, GABA-B/*metabolism, Hippocampus/*growth & development/*metabolism, In Vitro Techniques, Nowicky A V, Organophosphorus Compounds/pharmacology, Rats, Receptors, Teyler T J

Age related changes of social memory/recognition in male Fischer 344 rats.

Two different habituation-dishabituation test paradigms were used to evaluate differences in social memory/recognition among 3-, 15- and 22-month-old male Fischer 344 rats. For test 1, males received three 2-min exposures to the same stimulus…

Discriminative stimulus properties of CGS 10746B: similarity to dopamine D1 receptor antagonists.

CGS 10746B is an imidazole-derivative related to the atypical antipsychotic clozapine which produces a decrease in dopamine release without altering dopamine metabolism or occupying D2 receptors. Rats were trained on an appetitively-motivated,…

Para-chlorophenylalanine treatment inhibits the expression of vasoactive intestinal peptide messenger RNA in rat anterior pituitary.

Adult male Sprague-Dawley rats were treated with para-chlorophenylalanine (pCPA) or alpha-methyl tyrosine (alpha-MT) to study the effect of serotonin or catecholamine depletion on the expression of vasoactive intestinal peptide (VIP) messenger RNA in…

Effects of aging on spinal opioid-induced antinociception.

Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive…

Reducing the time needed to conduct conditioned place preference testing.

The objective of the present experiment was to demonstrate whether four days of twice-a-day conditioned place conditioning produces a preference that is equivalent to that produced by using eight days of once-a-day training. Two doses of the…

Tags: 1992, Alkaloids/pharmacology, Animals, Calcagnetti D J, Choice Behavior/*drug effects, Conditioning, Experimental/instrumentation/methods, Inbred Strains, Male, Motor Activity/drug effects, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Psychology, Psychotropic Drugs/pharmacology, Rats, Schechter M D

Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.

1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats…

Differential training sequence effect upon psychostimulant discrimination.

1. Previous studies indicate that rats trained to discriminate either cathinone or cathine from its vehicle have a diminished discriminative performance when tested 24 hours after a drug administration when compared to tests conducted after a vehicle…

Tags: 1993, Alkaloids/pharmacology, Animals, Appetite Depressants/pharmacology, Central Nervous System Stimulants/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Food, Male, Phenylpropanolamine/pharmacology, Progress in neuro-psychopharmacology & biological psychiatry, Psychotropic Drugs/pharmacology, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley

Dopaminergic mediation of the stimulant generalization of nicotine.

1. Experiments were conducted to investigate if the psychostimulant cathinone, like d-amphetamine, would produce generalization of the discriminative stimulus effects of nicotine. 2. Rats were trained to discriminate either 0.8 mg/kg cathinone from…

Conditioned place preference/aversion to fenfluramine in fawn hooded and sprague-Dawley rats.

The Fawn Hooded (FH) rat strain possesses a genetic platelet storage pool deficiency which leads to an impaired capacity for platelets to store and release serotonin. While the relationship between this deficit and possible alterations in brain…

Tags: 1994, Animals, Avoidance Learning/*drug effects, Blood Platelets/metabolism, Brain Chemistry/genetics, Fenfluramine/*pharmacology, Habituation, Inbred Strains, Meehan S M, Platelet Storage Pool Deficiency/physiopathology, Progress in neuro-psychopharmacology & biological psychiatry, Psychophysiologic/drug effects, Rats, Schechter M D, Serotonin/metabolism/physiology, Species Specificity, Sprague-Dawley

Nicotine place preference using the biased method of conditioning.

1. The objective of the experimentation was to determine whether nicotine (NIC, 0.8 mg/kg subcutaneously administered) would produce a conditioned place preference (CPP) in rats confined for thirty min to their less-preferred side in a three…

Tags: 1994, Animals, Calcagnetti D J, Conditioning, Cues, Injections, Male, Motor Activity/drug effects, Nicotine/*pharmacology, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Rats, Schechter M D, Sprague-Dawley, Subcutaneous

Scopolamine-physostigmine combination does not substitute for nicotine.

1. Male Sprague-Dawley rats were trained to discriminate 0.4 mg/kg nicotine subcutaneously administered from its saline vehicle in a food-motivated operant discrimination task. Once trained, the discriminative performance was observed to be…

Serotonergic involvement in the regulation of prolactin and vasoactive intestinal peptide mRNA expression in the rat anterior pituitary.

These studies examined the contribution of serotonin (5-HT) to the control of prolactin (PRL) and vasoactive intestinal peptide (VIP) messenger RNA expression in rat anterior pituitary. Daily injection of rats with the biosynthetic precursor to…

Induction of giant depolarizing potentials by zinc in area CA1 of the rat hippocampus does not result from block of GABAB receptors.

The possibility that zinc (Zn2+) induces giant depolarizing potentials (GDPs) by blocking pre- and postsynaptic gamma-aminobutyric acidB (GABAB) receptors in area CA1 of rat hippocampal slices was investigated. Monosynaptic GABAA receptor-mediated…

Tags: *GABA-A Receptor Antagonists, 1992, 2-Amino-5-phosphonovalerate/pharmacology, Animals, Baclofen/pharmacology, Harrison N L, Hippocampus/cytology/*drug effects, In Vitro Techniques, Interneurons/drug effects/physiology, Lambert N A, Levitin M, Membrane Potentials/drug effects, Neuroscience letters, Quinoxalines/pharmacology, Rats, Synapses/drug effects, Zinc/*pharmacology

Role of adenosine in heterosynaptic, posttetanic depression in area CA1 of hippocampus.

Conditioning stimulation of afferent fibers in hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of responses evoked by stimulation of an independent set of afferent fibers. PTD was present within 5 s of conditioning…

Expression of alpha-cardiac myosin heavy chain in normal and denervated rat muscle spindles.

Whether any fibers in rat hindlimb muscles express alpha-cardiac myosin heavy chain (MHC) is uncertain. Expression of alpha-cardiac MHC mRNA and the polypeptide for which it codes were examined in control and denervated rat muscle spindles using in…

Tags: 1995, Animals, Denervation, In Situ Hybridization, McWhorter D L, Messenger/metabolism, Muscle Spindles/*metabolism/physiology, Myocardium/*metabolism, Myosin Heavy Chains/*metabolism, Neuroscience letters, Rats, RNA, Signs S A, Sprague-Dawley, Time Factors, Walro J M, Wang J

The noradrenergic component contributing to spinal fentanyl-induced antinociception is supraspinally mediated.

1. Male Sprague-Dawley rats were fitted with intrathecal (i.t.) and intracerebroventricular (i.c.v.) catheters. Fentanyl was injected either i.t. or i.c.v., and the antinociceptive efficacy of fentanyl was evaluated using the tail-flick…

A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.

1. Male Sprague-Dawley rats were chronically tested with intrathecal (i.t.) receptor selective opioid antagonists to determine if antinociceptive supersensitivity developed to selective i.t. opioid receptor agonists. 2. A subcutaneously implanted…

Pentobarbital differentially inhibits N-methyl-D-aspartate and kainate-stimulated [3H]noradrenaline overflow in rat cortical slices.

1. This study examined the ability of pentobarbital to inhibit NMDA and kainate-stimulated [3H]noradrenaline ([3H]NA) overflow in rat brain cortical slices. 2. Pentobarbital inhibited NMDA-evoked [3H]NA overflow at 100 microM and greater and…

Tags: *Excitatory Amino Acid Agonists, 1995, Adrenergic alpha-Agonists/metabolism, Animals, Brown L M, GABA Modulators/*pharmacology, General pharmacology, Kainic Acid/*antagonists & inhibitors, Male, N-Methylaspartate/*antagonists & inhibitors, Norepinephrine/metabolism, Pentobarbital/*pharmacology, Prefrontal Cortex/*drug effects, Rats, Sprague-Dawley

N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 of rat hippocampus: input-specific induction and preclusion in a non-tetanized pathway.

We previously reported that an N-methyl-D-aspartate receptor-independent component of long-term potentiation with an apparent delayed onset can be induced in area CA1 of the hippocampus. Here we show that some but not all of this delay in onset can…

Tags: 1992, 2-Amino-5-phosphonovalerate/*pharmacology, Animals, Electron, Evoked Potentials/drug effects, Grover L M, Hippocampus/*physiology, In Vitro Techniques, Microscopy, N-Methyl-D-Aspartate/*physiology, N-Methylaspartate/*pharmacology, Neuroscience, Pyramidal Tracts/drug effects/*physiology, Rats, Receptors, Teyler T J, Time Factors

Browse Items (424 total)