Browse Items (176 total)

Normal aging is associated with cardiac, vascular, and pulmonary adaptations that significantly affect the individual's ability to maintain homeostasis. To understand the changes associated with aging, we developed a laboratory exercise that compares…

We wanted a new and innovative method of engaging students in interactive learning. To this end, we developed an educational tool that compares and contracts the cardiopulmonary responses to exercise in an individual with heart failure with an…

This study was conducted to determine whether increased myocardial energy demand plays a role in norepinephrine (NE)-induced left ventricular (LV) dysfunction. A range of arterial pressure-heart rate (P-R) products (myocardial energy demand) was…

We tested the hypothesis that reflex responses to mechanical [increase in left atrial pressure (LAP) 0-25 mmHg] and chemical stimulation [left atrial injection of phenylbiguanide (PBG), 0.5-10 mg/kg] of cardiopulmonary receptors are greater in female…

The effect of daily spontaneous running on blood pressure homeostasis (BPH) was evaluated in 19 male and 13 female control rats and 7 male and 13 female daily spontaneous running rats subjected to surgery and subsequent repetitive hemodynamic…

We determined the time course of changes in extravascular lung water (EVLW) that occur after massive sympathetic activation produced by intracisternal veratrine administration in chloralose-anesthetized dogs. Three groups of dogs were studied. In the…

The elevation of venous pressure (Pv) in isolated perfused organs causes organ weight to increase in a biphasic manner. The initial rapid phase results primarily from an increase in blood volume (BV), whereas the second slower phase is generally…

Failure to attend the first newborn health supervision visit is an important problem for the Continuity Care Clinic of Children's Hospital Medical Center of Akron, Ohio. The goal of this study was to use objective data from the neonatal record to…

The likelihood ratio approach for DNA typing in criminal cases is described. It is shown how this approach uses both the sizes and pattern of discrepancies between the crime scene profile of fragment lengths and the suspect profile for quantifying…

A peculiar hyaline sarcoplasmic inclusion in the atrial myocytes of old female Syrian hamsters is described. This type of inclusion resembles that described in rare human cardiomyopathy. They have also been described in other rodents and have been…

These studies were designed to investigate how the aging process alters the spinal antinociceptive efficacy of mu (mu), delta (delta) and epsilon (epsilon) opioid receptor agonists administered intrathecally (i.t.) in rats. Various doses of the mu…

Physicians, parents or guardians, and the community all have an important role in preventive care for adolescents. Adolescents desire more interaction with their primary care providers. Physicians can influence the health care of adolescents by…

Forefoot pain in the athlete is common. Generally, the symptoms are a result of overuse. The initial treatment strategy is to modify both exercise and shoewear. Specific diagnoses of the problem is key to proper treatment. Usually, the history and…

Otosclerosis often occurs as a unilateral mixed or conductive hearing loss. In the absence of retrocochlear findings, otologists usually do not pursue further diagnostic testing. A patient who presented to the Warren Otologic Group with a unilateral…

Recognition of sacroiliac disease has been integral to arthritis diagnostic approaches. However, intra- and inter-observer variation have been recognized as limiting factors in radiologic assessment of the sacroiliac joint. The assumption that such…

Reactive arthritis is an important source of morbidity. It is acquired through infectious agent diarrhea (food poisoning) or from sexual contact. Recognition is important because it allows a therapeutic approach that usually results in improvement of…

Gynecologists are often responsible for the primary care of postmenopausal women. In this role, they become responsible for the assessment and subsequent management issues surrounding the prevention of atherosclerotic disease. The effects of estrogen…

Four cases histories illustrate the process of defining the cause of hyponatremia: Categorize the patient's volume status; determine kidney function and kidney's response to volume stimulus; measure urine osmolality; consider other factors, including…

Abnormalities that increase water reabsorption can lead to hyponatremia, and the resulting water retention presents the threat of CNS volume changes. Avoid overcorrection of hyponatremia, however, as this causes similar changes. Also, be aware of…

Percutaneous transluminal angioplasty and renal artery bypass surgery are the most effective means of treating renal vascular disease and the hypertension it causes. Selection of the most appropriate treatment depends on the nature of the underlying…

Detection of renal vascular disease offers the opportunity to cure a patient with hypertension as well as to avert severe renal damage and lifelong dependence on dialysis. The crucial first step is to suspect renovascular lesions. Clues include the…

The genetically obese Zucker rat is a widely used model of early-onset obesity. Like obese children, these obese rats are hyperinsulinemic and have low GH secretion. However, data on linear growth and insulin-like growth factor-I (IGF-I) levels in…

An antibody to cytochrome P450 oxidoreductase, purified from rat liver, has been used for the immunohistochemical localization of cytochrome P450 oxidoreductase-like immunoreactivity in the rat central nervous system. The distribution of this…

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