Browse Items (11 total)
- Tags: Thoppil Roslin J
Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells.
Tags: 2013, Aerial, Antineoplastic Agents, Bishayee Anupam, Carcinoma, Desert Climate, Dose-Response Relationship, Drug, Harlev Eli, Hep G2 Cells, Hepatocellular/*drug therapy/pathology, Humans, Inhibitory Concentration 50, Liver Neoplasms/*drug therapy/pathology, Mandal Animesh, Medicinal/chemistry, Nevo Eviatar, Pharmaceutical biology, Phytogenic/administration & dosage/*pharmacology, Plant Components, Plant Extracts/administration & dosage/*pharmacology, Plants, Tetrazolium Salts/chemistry, Thiazoles/chemistry, Thoppil Roslin J, Time Factors
TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway.
Tags: 2016, Adapala Ravi K, Animals, Cappelli Holly C, Carcinoma, Cell Movement/physiology, Department of Integrative Medical Sciences, endothelial cell, Endothelial Cells/metabolism/pathology, Inbred C57BL, Kanugula Anantha K, Knockout, Lewis Lung/metabolism/*pathology, Mechanotransduction, Mice, NEOMED College of Medicine, Neovascularization, Oncotarget, Paruchuri Sailaja, Pathologic/*metabolism/pathology, rho-Associated Kinases/*metabolism, Rho/Rho kinase, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/*metabolism, TRPV4, tumor angiogenesis
Terpenoids as potential chemopreventive and therapeutic agents in liver cancer.
Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma.
Tags: *Phytotherapy, 2012, Alkylating Agents/toxicity, Animals, Anthocyanins/*therapeutic use, Antioxidants/therapeutic use, Barnes Kendra F, Bhatia Deepak, Bishayee Anupam, Blotting, Carcinoma, Current cancer drug targets, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diet, Diethylnitrosamine/toxicity, Experimental/chemically induced/metabolism/*prevention & control, Glutathione Transferase, Haznagy-Radnai Erzsebet, Hepatocellular/chemically induced/metabolism/*prevention & control, Hohmann Judit, Immunoenzyme Techniques, Lipid Peroxidation/drug effects, Liver Neoplasms, Male, Messenger/genetics, NEOMED College of Pharmacy, NF-E2-Related Factor 2/genetics/*metabolism, Nitric Oxide Synthase Type II/genetics/metabolism, Oxidative Stress/*drug effects, Rats, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Ribes/*chemistry, RNA, Signal Transduction, Sprague-Dawley, Thoppil Roslin J, Tyrosine/analogs & derivatives/metabolism, Western
TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation.
Tags: 2015, Adapala Ravi K, Animals, Antineoplastic Agents/pharmacology, Cappelli Holly C, Cell Proliferation/drug effects, Department of Integrative Medical Sciences, Dudley Andrew C, Endothelial Cells/drug effects/metabolism, Kondeti Vinay, Leucine/analogs & derivatives/pharmacology, MAP Kinase Signaling System, Meszaros J Gary, Mice, NEOMED College of Medicine, Neoplasms/drug therapy/*metabolism/pathology, Neovascularization, Paruchuri Sailaja, Pathologic/drug therapy, Scientific reports, Sulfonamides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/drug effects/genetics/*metabolism, Up-Regulation
Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels.
Tags: 13-dienoic Acid/pharmacology, 15-Hydroxy-11 alpha, 2012, 9 alpha-(epoxymethano)prosta-5, American journal of physiology. Heart and circulatory physiology, Anilides/pharmacology, Animals, Bratz Ian N, Capsaicin/analogs & derivatives/pharmacology, Cinnamates/pharmacology, Coronary Vessels/drug effects/*metabolism/physiopathology, Damron Derek S, DelloStritto Daniel J, Department of Integrative Medical Sciences, Diabetes Mellitus, Diabetic Cardiomyopathies/drug therapy/*metabolism, Enzyme Inhibitors/pharmacology, Guarini Giacinta, Inbred C57BL, Kmetz John G, Large-Conductance Calcium-Activated Potassium Channels/antagonists & inhibitors/*metabolism, Male, Meszaros J Gary, Mice, Microvessels/drug effects/physiopathology, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Nitric Oxide/*metabolism, Ohanyan Vahagn A, Peptides/pharmacology, Thodeti Charles K, Thoppil Roslin J, TRPV Cation Channels/agonists/antagonists & inhibitors/biosynthesis/*metabolism, Type 2/drug therapy/*metabolism, Vasoconstrictor Agents/pharmacology, Vasodilation/drug effects
Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Tags: 2011, Animals, Anthocyanins/*therapeutic use, Anticarcinogenic Agents/therapeutic use, Apoptosis/drug effects, bcl-2-Associated X Protein/metabolism, Bishayee Anupam, Cell Proliferation/drug effects, Chemoprevention, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diethylnitrosamine, Down-Regulation, Experimental/metabolism/pathology, Folkesson Hans G, Haznagy-Radnai Erzsebet, Hohmann Judit, Liver Neoplasms, Liver Neoplasms/chemically induced/*prevention & control, Liver/pathology, Male, Mbimba Thomas, NEOMED College of Pharmacy, Phenobarbital, Plant Extracts/*therapeutic use, Proliferating Cell Nuclear Antigen/metabolism, Proto-Oncogene Proteins c-bcl-2/metabolism, Rats, Ribes/chemistry, Sipos Peter, Sprague-Dawley, The Journal of nutritional biochemistry, Thoppil Roslin J, Up-Regulation
Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms.
Tags: *Phytotherapy, 2011, Alkylating Agents/toxicity, Animals, Antioxidants/*therapeutic use, Bhatia Deepak, Bishayee Anupam, Blotting, Carcinogenesis, Carcinoma, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diethylnitrosamine/toxicity, Experimental/chemically induced/*drug therapy/metabolism, GA-Binding Protein Transcription Factor/*metabolism, gamma-Glutamyltransferase/metabolism, Hepatocellular/chemically induced/*drug therapy/metabolism, Immunoenzyme Techniques, Lansky Ephraim P, Lipid Peroxidation/drug effects, Liver Neoplasms, Male, NEOMED College of Pharmacy, Nevo Eviatar, Oxidative Stress, Plant Extracts/*therapeutic use, Punicaceae/*chemistry, Rats, Sprague-Dawley, Thoppil Roslin J, Western
Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/β-Catenin Signaling Pathway.
Tags: 2013, Animal Studies, Apoptosis, Bhatia Deepak, Bishayee Anupam, Blotting, Carcinoma, Darvesh Altaf S, Department of Pharmaceutical Sciences, Evidence-based Complementary & Alternative Medicine (eCAM), Experimental Studies, Gene Expression, Hepatocellular, Immunohistochemistry, In Vivo Studies, Mandal Animesh, NEOMED College of Pharmacy, One-Way Analysis of Variance, Pomegranate, Post Hoc Analysis, Protocols, Rats, Samtani Karishma A, STRUCTURAL equation modeling, Thoppil Roslin J, Western
Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ beta -Catenin Signaling Pathway.
TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals.
Tags: *Calcium Signaling, *Cell Differentiation, *Mechanotransduction, 2013, Adapala Ravi K, Animals, Cellular, Chilian William M, Department of Integrative Medical Sciences, Extracellular Matrix/metabolism/physiology, Fibroblasts/*physiology, Gene Knockdown Techniques, Journal of molecular and cellular cardiology, Luther Daniel J, Male, Meszaros J Gary, Monoterpenes/pharmacology, Myocardium/cytology, Myofibroblasts/metabolism, NEOMED College of Medicine, Paruchuri Sailaja, Rats, RNA, Small Interfering/genetics, Sprague-Dawley, Thodeti Charles K, Thoppil Roslin J, Transforming Growth Factor beta1/physiology, TRPM Cation Channels/antagonists & inhibitors/metabolism, TRPV Cation Channels/genetics/*metabolism