Browse Items · NEOMED Bibliography Database

Prenatal cocaine exposure leads to enhanced long-term potentiation in region CA1 of hippocampus.

Cocaine use by pregnant women is currently of concern for its social and economic impact. Clinical studies of cocaine exposed offspring are limited by methodological constraints. In this study we used a rabbit model to examine the effects of…

Tags: *Prenatal Exposure Delayed Effects, 1996, Animals, Brain research. Developmental brain research, Cocaine/*administration & dosage/pharmacology, Electrophysiology, Female, Hippocampus/*drug effects/physiology, In Vitro Techniques, Little J Z, Long-Term Potentiation/*drug effects, Narcotics/*administration & dosage/pharmacology, Neuronal Plasticity/drug effects, Pregnancy, Rabbits, Reference Values, Synapses/drug effects, Teyler T J

GABAa receptor-mediated field potentials are enhanced in area CA1 following prenatal cocaine exposure.

Prenatal cocaine exposure results in several documented changes in neurotransmitter receptor number and structure. Increases have been reported for cortical catecholamine and indoleamine receptor number and binding affinity, in the subunit expression…

Metabotropic glutamate receptor antagonist, (R,S)-alpha-methyl-4-carboxyphenyglycine, blocks two distinct forms of long-term potentiation in area CA1 of rat hippocampus.

The necessity of metabotropic glutamate receptors (mGluRs) in the induction of long-term potentiation (LTP) has recently been questioned. We examined the effect of (R,S)-alpha-methyl-4-caboxyphenylglycine (MCPG), a selective mGluR antagonist, on two…

Tags: 1995, Animals, Benzoates/*pharmacology, Calcium Channels/drug effects/metabolism/physiology, Electric Stimulation, Electrophysiology, Excitatory Amino Acid Antagonists/*pharmacology, Glycine/*analogs & derivatives/pharmacology, Grover L M, Hippocampus/drug effects/*physiology, In Vitro Techniques, Ion Channel Gating/drug effects, Little Z, Long-Term Potentiation/*drug effects, Metabotropic Glutamate/*antagonists & inhibitors, Neuroscience letters, Rats, Receptors, Teyler T J

Selective photothermolysis of the sebaceous glands for acne treatment.

BACKGROUND AND OBJECTIVES: The purpose of this study is to evaluate the efficacy of a long pulse diode laser (Cynosure, Inc.) to target and destroy enlarged sebaceous glands that are preloaded with Indocyanine green (ICG) chromophore. STUDY…

Tags: *Hyperthermia, *Photolysis, *Phototherapy, 2002, Acne Vulgaris/pathology/*therapy, Combined Modality Therapy, Department of Internal Medicine, Feasibility Studies, Follow-Up Studies, Humans, In Vitro Techniques, Induced, Lasers in surgery and medicine, Lloyd Jenifer R, Mirkov Mirko, NEOMED College of Medicine, Sebaceous Glands/pathology/*radiation effects, Time Factors, Treatment Outcome

Endogenous mGluR activity suppresses GABAergic transmission in avian cochlear nucleus magnocellularis neurons.

GABAergic transmission in the avian cochlear nucleus magnocellularis (NM) of the chick is subject to modulation by gamma-aminobutyric acid type B (GABA(B)) autoreceptors. Here, I investigated modulation of GABAergic transmission in NM by metabotropic…

Tags: 2-Amino-5-phosphonovalerate/pharmacology, 2007, Amino Acids/pharmacology, Animals, Chickens/*physiology, Cochlear Nucleus/*cytology/*physiology, Department of Anatomy & Neurobiology, Electric Stimulation, Excitatory Amino Acid Antagonists/pharmacology, Excitatory Postsynaptic Potentials/physiology, GABA-B Receptor Agonists, GABA-B Receptor Antagonists, GABA-B/physiology, gamma-Aminobutyric Acid/*physiology, Glycine/analogs & derivatives/pharmacology, In Vitro Techniques, Journal of neurophysiology, Kinetics, Lu Yong, Membrane Potentials/drug effects, Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism/physiology, Models, NEOMED College of Medicine, Neurological, Neurons/*physiology, Patch-Clamp Techniques, Receptors, Resorcinols/pharmacology, Synapses/physiology, Synaptic Transmission/*physiology, Xanthenes/pharmacology

Effect of elevated vascular pressure transients on protein permeability in the lung.

Neurogenic pulmonary edema (NPE) may develop in individuals with head trauma or seizures and is generally thought to have a hydrostatic basis in the severe degree of pulmonary hypertension that occurs. Recently, it has been suggested that vascular…

Tags: *Blood Pressure, 1989, Animals, Blood Proteins/*metabolism, Dogs, Female, Hypertension/physiopathology, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Lung/metabolism/*physiopathology, Male, Maron M B, Pulmonary Edema/*etiology/metabolism/physiopathology

Pulmonary vasoconstriction in a canine model of neurogenic pulmonary edema.

The intracisternal administration of veratrine to the chloralose-anesthetized dog produces pulmonary hypertension (PH) and neurogenic pulmonary edema (NPE). To determine whether pulmonary vasoconstriction, mediated by a circulating agent, contributes…

Time course of blood volume changes in an isolated lung lobe after venous pressure elevation.

The elevation of venous pressure (Pv) in isolated perfused organs causes organ weight to increase in a biphasic manner. The initial rapid phase results primarily from an increase in blood volume (BV), whereas the second slower phase is generally…

Tags: *Blood Volume/drug effects, *Pulmonary Circulation, *Venous Pressure, 1994, Animals, Dogs, Extravascular Lung Water/metabolism, Female, In Vitro Techniques, Indicator Dilution Techniques, Indocyanine Green, Journal of applied physiology (Bethesda, Md. : 1985), Lane S M, Lung/*physiology, Male, Maron M B, Papaverine/pharmacology, Perfusion, Time Factors

Effect of extreme elevations in venous pressure on reflection coefficient in the lung.

We determined whether the solvent drag reflection coefficient (sigma f) for total proteins of a canine perfused left lower lung lobe (LLL) preparation decreases at elevated venous pressures (Pv). We found that sigma f (estimated using the…

Effect of papaverine on pulmonary vascular permeability to proteins.

Previous studies have suggested that papaverine, a drug commonly used in studies of transvascular fluid and solute exchange to eliminate confounding effects of changes in vascular tone, may itself increase vascular permeability. In this study, we…

Tags: 1988, Animals, Blood Proteins/*metabolism, Capillary Permeability/*drug effects, Dogs, Female, In Vitro Techniques, Journal of applied physiology (Bethesda, Md. : 1985), Male, Maron M B, Osmosis, Papaverine/blood/*pharmacology, Pilati C F, Pulmonary Circulation/*drug effects, Serotonin/pharmacology, Vasodilation/drug effects, Water-Electrolyte Balance/drug effects

Aging and sex differences in striatal dopaminergic function.

In this report the potassium- (30 mM) and amphetamine- (10 microM) stimulated responses of dopamine (DA) and 3,4-dihydroxy phenylacetic acid (DOPAC) from superfused striatal tissue of female and male mice as sampled at 2, 6, 18 and 24 months of age…

Estrogen, but not testosterone, attenuates methamphetamine-evoked dopamine output from superfused striatal tissue of female and male mice.

The gonadal steroid hormone, estrogen, has the capacity to function as a neuroprotectant against methamphetamine (MA)-induced neurotoxicity of the nigrostriatal dopaminergic system within female, but not male, mice. In an attempt to understand some…

Tags: 2003, Anderson L I, Animals, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Estrogens/*metabolism, Female, In Vitro Techniques, Male, Methamphetamine/*pharmacology, Mice, Myers R E, Neuropharmacology, Orchiectomy, Ovariectomy, Perfusion, Testosterone/*metabolism

The modulation of long-term potentiation by delta-9-tetrahydrocannabinol in the rat hippocampus, in vitro.

The duration of long-term potentiation (LTP) of the CA1 evoked field potential in rat hippocampal slices was significantly modulated by pre-treatment of slices with delta-9-tetrahydrocannabinol (THC) added to the incubation media. The three THC doses…

Tags: 1987, Animals, Brain research bulletin, Dronabinol/*pharmacology, Evoked Potentials/drug effects, Hippocampus/*drug effects/physiology, In Vitro Techniques, Kinetics, Male, Nowicky A V, Pyramidal Tracts/drug effects/physiology, Rats, Teyler T J, Time Factors, Vardaris R M

Effect of peak inspiratory pressure on the filtration coefficient in the isolated perfused rat lung.

Positive inspiratory pressure- (PIP) ventilated, isolated rat lungs become edematous when perfused at rates approximately the normal cardiac output. The study was conducted to test the hypothesis that high peak inspiratory pressures contribute to the…

A critical period for long-term potentiation in the developing rat visual cortex.

The in vitro rodent visual cortical slice preparation demonstrates a critical period for long-term potentiation (LTP). Current source density (CSD) analysis reveals peak potentiation of both supra-(layers II-III) and infragranular (layers V) layers…

Tags: 1988, Aging, Animals, Brain research, Electric Stimulation, In Vitro Techniques, Neuronal Plasticity, Newborn, Perkins A T 4th, Rats, Teyler T J, Visual Cortex/*growth & development/physiology

Factors involved in left ventricular dysfunction after massive sympathetic activation.

We sought to determine whether catecholamines are responsible for the depressed left ventricular (LV) function that follows massive sympathetic nervous system (SNS) activation and whether the additional myocardial energy demands of

Tags: *Ventricular Function, 1992, Animals, Blood Pressure/drug effects/physiology, Bosso F J, Catecholamines/physiology, Female, Heart Conduction System/*physiology, Heart Diseases/*physiopathology, Heart Rate/drug effects, In Vitro Techniques, Left, Male, Maron M B, Pilati C F, Rabbits, Sympathetic Nervous System/drug effects/*physiology, The American journal of physiology, Veratrine/pharmacology

Persistent left ventricular dysfunction after cocaine treatment in rabbits.

The present study was undertaken to determine whether the diminished cardiac performance associated with cocaine administration persists after the drug has been eliminated from the body. Cocaine (5 or 10 mg/kg iv) was administered to conscious (n =…

Role of EDRF in the cardiopulmonary dysfunction produced by massive sympathetic activation.

This study was undertaken to determine whether endothelium-derived relaxing factor (EDRF) modulates the pulmonary and systemic hemodynamic responses to massive sympathetic nervous system (SNS) activation and, in so doing, also modulates the degree of…

Herpes simplex virus type 1 penetration initiates mobilization of cell surface proteins.

Changes in membrane structure resulting from herpes simplex virus 1 (HSV-1) penetration were detected using fluorescence photobleaching recovery methods. The effect could be blocked by inhibitors of viral and cellular processes involved in virus…

Redox-dependent coronary metabolic dilation.

We have observed that hydrogen peroxide (H2O2), the dismutated product of superoxide, is a coronary metabolic dilator and couples myocardial oxygen consumption to coronary blood flow. Because the chemical activity of H2O2 favors its role as an…

Tags: *Paracrine Communication, *Vasodilation/drug effects, 2007, Acetylcysteine/pharmacology, American journal of physiology. Heart and circulatory physiology, Animals, Antioxidants/pharmacology, Cardiac/drug effects/*metabolism, Chilian William M, Conditioned/metabolism, Coronary Vessels/drug effects/enzymology/*metabolism, Culture Media, Department of Integrative Medical Sciences, Dick Gregory M, Dithiothreitol/pharmacology, Enzyme Activation, Fluorescence, Hydrogen Peroxide/metabolism, Imidazoles/pharmacology, In Vitro Techniques, Kiyooka Takahiko, Microscopy, Myocytes, NEOMED College of Medicine, Nitroprusside/pharmacology, Oxidation-Reduction, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism, Park Yoonjung, Phosphorylation, Protein Kinase Inhibitors/pharmacology, Pyridines/pharmacology, Rats, Reactive Oxygen Species/*metabolism, Reducing Agents/pharmacology, Rocic Petra, Rogers Paul A, Saitoh Shu-ichi, Sulfhydryl Compounds/*metabolism, Swafford Albert, Vasodilator Agents/pharmacology, Viswanathan Chandrasekar, Wistar, Zhang Cuihua

Localization and function of NK(3) subtype tachykinin receptors of layer V pyramidal neurons of the guinea-pig medial prefrontal cortex.

The NK(3) subtype of tachykinin receptor has been implicated as a modulator of synaptic transmission in several brain regions, including the cerebral cortex. The localization and expression of NK(3) receptors within the brain vary from species to…

Tags: 2008, Animals, Autoradiography/methods, Dose-Response Relationship, Drug, Drug Interactions, Excitatory Amino Acid Antagonists/pharmacology, Excitatory Postsynaptic Potentials/drug effects/radiation effects, Guinea Pigs, In Vitro Techniques, Iodine Isotopes/pharmacokinetics, Male, Medd A M, Membrane Potentials/drug effects/physiology/radiation effects, Neurokinin B/analogs & derivatives/pharmacokinetics, Neurokinin-3/agonists/antagonists & inhibitors/*metabolism, Neuroscience, Patch-Clamp Techniques, Peptide Fragments/pharmacology, Prefrontal Cortex/*cytology, Protein Binding/drug effects, Pyramidal Cells/drug effects/*metabolism, Quinolines/pharmacology, Quinoxalines/pharmacology, Receptors, Simmons M A, Sobotka-Briner C D, Substance P/analogs & derivatives/pharmacology, Valine/analogs & derivatives/pharmacology

Sex differences in nitric oxide-mediated attenuation of vascular reactivity to vasopressin are abolished by gonadectomy.

In the rat thoracic aorta, contractile responses to vasopressin are two-fold higher in females than in males, primarily because nitric oxide-mediated attenuation of contraction is greater in males than in females. To determine the role of the gonadal…

Tags: *Long-Term Potentiation, *Neuronal Plasticity, 1999, Animals, Brain/*physiology, Electrophysiology/methods, Glutamic Acid/physiology, In Vitro Techniques, Memory/*physiology, Methods (San Diego, Calif.), Models, Neurological, Synapses/*physiology, Synaptic Transmission, Teyler T J

Browse Items (65 total)