Browse Items · NEOMED Bibliography Database

Contrast-induced encephalopathy presenting as acute subarachnoid hemorrhage

Contrast media induced encephalopathy is a rare complication of contrast administration characterized by nonspecific neurological signs and symptoms that may present both clinically and radiolographically as subarachnoid hemorrhage. While there are…

Tags: 2018, allergy, American Journal of Emergency Medicine, Contrast, Contrast-induced, coronary intervention, Emergency Medicine, Encephalitis, Encephalopathy, gadolinium, Journal Article, Liu L, Neurotoxicity, Oxidative Stress, Pokersnik J A, rat cortical-neurons, SAH, Simon E L

Cross-Talk Between Stem Cells and the Dysfunctional Brain is Facilitated by Manipulating the Niche: Evidence from an Adhesion Molecule

In the injured brain, the behavior of neural stem/progenitor cells (NSCs) is regulated by multiple converging factors encountered in the niche, which is composed of several neural and non-neural cell types. Signals emanating from the host influence…

Nrf2/ARE pathway attenuates oxidative and apoptotic response in human osteoarthritis chondrocytes by activating ERK1/2/ELK1-P70S6K-P90RSK signaling axis.

Nrf2, a redox regulated transcription factor, has recently been shown to play a role in cartilage integrity but the mechanism remains largely unknown. Osteoarthritis (OA) is a multifactorial disease in which focal degradation of cartilage occurs.…

Mechanical Ventilation Antioxidant Trial.

BACKGROUND: Many patients each year require prolonged mechanical ventilation. Inflammatory processes may prevent successful weaning, and evidence indicates that mechanical ventilation induces oxidative stress in the diaphragm, resulting in atrophy…

Tags: 2015, 80 and over, Acetylcysteine, Adult, Aged, American journal of critical care : an official publication, American Association of Critical-Care Nurses, Antioxidants, Antioxidants/*therapeutic use, Artificial, Artificial/*adverse effects, Ascorbic Acid – Administration and Dosage, Ascorbic Acid/therapeutic use, Chi Square Test, Clochesy John M, Critical Care/*methods, Critical Illness, Critically Ill Patients, Cystine/analogs & derivatives/therapeutic use, Data Analysis Software, Department of Internal Medicine, Dietary Supplementation, Double-Blind Method, Double-Blind Studies, Female, Funding Source, Goldstein Lawrence S, Howe Kimberly P, Human, Humans, Inflammation/*drug therapy/*etiology, Intensive Care Units, Length of Stay, Log-Rank Test, Male, Mantel-Haenszel Test, Middle Age, Middle Aged, NEOMED College of Medicine, Owen Hugh, Oxidative Stress, Oxidative Stress/*drug effects, Prospective Studies, RANDOMIZED controlled trials, Respiration, T-Tests, Time Factors, Treatment Outcome, Ventilator Weaning, Vitamin E, Vitamin E/therapeutic use, Vitamins/therapeutic use

Selenium in the prevention and treatment of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) happens to be one of the most lethal cancers in the world. Even though most cases occur in the developing world, reported cases in Western Europe as well as North America are on a steep rise. Human HCC etiology includes…

Tags: 2010, Animal, Animals, Anti-cancer agents in medicinal chemistry, Anticarcinogenic Agents/*therapeutic use, Bishayee Anupam, Carcinoma, Darvesh Altaf S, Department of Pharmaceutical Sciences, Hepatocellular/chemically induced/*drug therapy/etiology/*prevention & control, Humans, Liver Neoplasms/chemically induced/*drug therapy/etiology/*prevention & control, Models, NEOMED College of Pharmacy, Oxidative Stress, Selenium/*therapeutic use

Cholesterol 7alpha-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis.

Cholesterol 7alpha-hydroxylase (CYP7A1) plays a critical role in control of bile acid and cholesterol homeostasis. Bile acids activate farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) to regulate lipid, glucose, and energy…

The role of mitochondrial bioenergetics and reactive oxygen species in coronary collateral growth.

Coronary collateral growth is a process involving coordination between growth factors expressed in response to ischemia and mechanical forces. Underlying this response is proliferation of vascular smooth muscle and endothelial cells, resulting in an…

Metabolic dysfunction in obstructive sleep apnea: A critical examination of underlying mechanisms.

It has recently become clear that obstructive sleep apnea (OSA) is an independent risk factor for the development of metabolic syndrome, a disorder of defective energy storage and use. Several mechanisms have been proposed to explain this finding,…

Tags: 2015, hypoxia, Jun Jonathan C, Mesarwi Omar A, Oxidative Stress, Polotsky Vsevolod Y, Sharma Ellora V, Sleep and biological rhythms, sleep fragmentation, sympathetic nervous system

Pomegranate-mediated chemoprevention of experimental hepatocarcinogenesis involves Nrf2-regulated antioxidant mechanisms.

Hepatocellular carcinoma (HCC), one of the most prevalent and lethal cancers, has shown an alarming rise in the USA. Without effective therapy for HCC, novel chemopreventive strategies may effectively circumvent the current morbidity and mortality.…

Hepatic Mitochondrial Defects in a Nonalcoholic Fatty Liver Disease Mouse Model Are Associated with Increased Degradation of Oxidative Phosphorylation Subunits.

Nonalcoholic fatty liver disease (NAFLD) is associated with hepatic mitochondrial dysfunction characterized by reduced ATP synthesis. We applied the (2)H2O-metabolic labeling approach to test the hypothesis that the reduced stability of oxidative…

Increased serotransferrin and ceruloplasmin turnover in diet-controlled patients with type 2 diabetes.

Type 2 diabetes mellitus (T2DM) is associated with oxidative stress and perturbed iron metabolism. Serotransferrin (Trf) and ceruloplasmin (Cp) are two key proteins involved in iron metabolism and anti-oxidant defense. Non-enzymatic glycation and…

Tags: *Ceruloplasmin, *Deamidation, *Heavy water metabolic labeling, *High resolution mass spectrometry, *Iron metabolism, *LC-MS/MS, *Non-enzymatic glycation, *Oxidative Stress, *Protein Processing, *Proteome dynamics, *Serotransferrin, *Type 2 diabetes mellitus, 2017, Adult, Amino Acid Sequence, Bena James, Case-Control Studies, Ceruloplasmin/genetics/*metabolism, Department of Pharmaceutical Sciences, Deuterium/metabolism, Diabetes Mellitus, Diabetic, Diet, Female, Free radical biology & medicine, Gene Expression Regulation, Glycated Hemoglobin A/genetics/metabolism, Glycosylation, Golizeh Makan, Humans, Ilchenko Serguei, Iron/*metabolism, Isotope Labeling, Kashyap Sangeeta R, Kasumov Takhar, Lee Kwangwon, Male, Middle Aged, NEOMED College of Pharmacy, Osme Abdullah, Oxidation-Reduction, Oxidative Stress, Post-Translational, Proteolysis, Sadygov Rovshan G, Transferrin/genetics/*metabolism, Type 2/diet therapy/genetics/*metabolism/pathology

Increased mitochondrial prooxidant activity mediates up-regulation of Complex I

In response to oxidative stress, mitochondrial Complex I is reversibly

BCNU-induced gR2 defect mediates S-glutathionylation of Complex I and respiratory uncoupling in myocardium.

A deficiency of mitochondrial glutathione reductase (or GR2) is capable of adversely affecting the reduction of GSSG and increasing mitochondrial oxidative stress. BCNU [1,3-bis (2-chloroethyl)-1-nitrosourea] is an anticancer agent and known…

Tags: 2014, Alkylating/*adverse effects/pharmacology, Animals, Antineoplastic Agents, Biochemical pharmacology, Cardiotoxins/adverse effects/pharmacology, Carmustine/*adverse effects/pharmacology, Cattle, Cell Line, Chen Chwen-Lih, Chen Yeong-Renn, Complex I, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Fatty Acids, Glutathione reductase, Glutathione Reductase/*antagonists & inhibitors/metabolism, Glutathione/*metabolism, Guarini Giacinta, Heart Ventricles/drug effects/metabolism/physiopathology, Heart/*drug effects/metabolism, Ion Channels/metabolism, Kang Patrick T, Left/*chemically induced/metabolism/physiopathology, Male, Mice, Mitochondria, Mitochondrial Proteins/metabolism, NEOMED College of Medicine, Nonesterified/metabolism, Oxidative Stress, Oxidative Stress/drug effects, Post-Translational/drug effects, Protein Processing, Rats, Ren Pei, S-Glutathionylation, Sprague-Dawley, Superoxide Dismutase/genetics/metabolism, Systolic dysfunction, Transgenic, Uncoupling Protein 3, Ventricular Dysfunction

Browse Items (53 total)