Browse Items · NEOMED Bibliography Database

Ethics and micromanaged care.

The ethical foundation on which my medical practice is based was recently shaken by an episode involving the intrusion of managed care into my practice. With the patient's informed consent, I prescribed a medication that I knew would not work.

The role of the part-time physician-teacher in dermatology.

As we approach the 21st century, specialty training programs in dermatology are feeling increasing pressures that have begun to erode clinical teaching. Full-time faculty members are being asked to spend more time in patient care to support an…

Tags: *Employment, *Teaching, 1996, Archives of dermatology, Brodell R T, Dermatology/*education

Learning and teaching in dermatology. A practitioner's guide.

BACKGROUND: The explosion of medical knowledge, the influence of communications technology, and the pressures for health care reform challenge dermatologists to learn efficiently and teach effectively. OBSERVATIONS: The vast body of material on…

Tags: 1996, Archives of dermatology, Bickers D R, Brodell R T, Chren M M, Dermatology/*education, Teaching/*methods, Wile M Z

Survey analysis of the American Board of Surgery In-Training Examination.

OBJECTIVE: To determine how other program directors use the American Board of Surgery In-Training Examination (ABSITE) scores in the resident evaluation process. DESIGN: A cover letter and a printed one-page survey of eight questions about individual…

Tags: *Educational Measurement, *Internship and Residency, *Specialty Boards, 1996, Abdu R A, Archives of surgery (Chicago, Ill. : 1960), General Surgery/*education, Humans, Surveys and Questionnaires, United States

Inhibition of long-term potentiation development in rat hippocampal slice by alpha 2-macroglobulin, an acute-phase protein in the brain.

Alpha-2-macroglobulin (alpha 2M) in the rat and human brain is an acute-phase protein synthesized primarily by astrocytes, and it has been implicated in Alzheimer's disease and other neuropathological processes. The activated forms of alpha 2M, but…

Tags: 1996, alpha-Macroglobulins/*pharmacology, Animals, Cavus I, Electric Stimulation, Hippocampus/drug effects/*physiology, Humans, In Vitro Techniques, Journal of neuroscience research, Koo P H, Long-Term Potentiation/*drug effects, Methylamines/pharmacology, Neurites/drug effects/*physiology, Pyramidal Cells/drug effects/physiology, Rats, Synapses/drug effects/physiology, Synaptic Transmission/drug effects, Teyler T J, Time Factors

Survey of cadaveric donors to a body donation program: 1978-1993.

Body donation files from the Department of Anatomy at Northeastern Ohio Universities College of Medicine were reviewed from the 569 donors used in our program from 1978-1993. The data were entered into a computerized database to evaluate the…

Protein kinase and phosphatase activity regulate the form of synaptic plasticity expressed.

Long-term potentiation (LTP) and long-term depression (LTD) are calcium-dependent forms of synaptic plasticity observed in area CA1 of the hippocampus. Low-frequency tetani (1-5 Hz) activates protein phosphatases to induce LTD, whereas high-frequency…

Tags: 1996, Animals, Calcium/pharmacology, Coussens C M, Neuronal Plasticity/*physiology, Phosphoric Monoester Hydrolases/*physiology, Protein Kinases/*physiology, Rats, Synapse (New York, N.Y.), Synaptic Transmission/drug effects/*physiology, Teyler T J

Alteration of dopamine release by rat caudate putamen tissues superfused with alpha 2-macroglobulin.

Monoamine-activated alpha-2-macroglobulin (alpha 2M) has been shown to decrease the dopamine concentrations in rat caudate putamen (CP) in vivo as well as inhibit choline acetyltransferase activities in the culture of basal forebrain neurons. In this…

Inhibition of the G2/M transition of the cell cycle by methyl-2,5-dihydroxycinnamate in human lymphoid cells.

Immortalized human lymphoid cells treated with Methyl-2,5-dihydroxycinnamate (MDHC), a stable analog of erbstatin, inhibited the G2/M transition of the cell cycle. The MDHC inhibition of the cell cycle was observed at concentrations well below the…

Tags: 1996, Biochemical and biophysical research communications, Cell Line, Cinnamates/*pharmacology, Cultured, G2 Phase/*drug effects, Humans, Jamison J M, Koch J A, Lymphocytes/cytology/*drug effects, Mitosis/*drug effects, Monocytes/cytology/drug effects, Rosenthal K S, Summers J L, Transformed, Tumor Cells

The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7 alpha-hydroxylase gene (CYP7A).

The activity of the rat CYP7A/luciferase reporter gene was increased five-fold by all-trans retinoic acid (atRA) or 9-cis retinoic acid (9cRA) in transient transfection assay in HepG2 cells. Cotransfection with retinoid X receptor (RXR) stimulated…

Synergistic antitumour activity of vitamins C and K3 against human prostate carcinoma cell lines.

Vitamins C, K3 (VC, VK3) and a VC/VK3 combination with a VC:VK3 ratio of 100:1 were assayed for their antitumour activity against two human prostatic carcinoma cell lines. Co-administration of the vitamins enhanced the antitumour activity 5- to…

Spatial and temporal variations in extracellular matrix of periocular and corneal regions during corneal stromal development.

The development of the avian corneal stroma occurs in discrete developmental stages. During this sequence of events, the neural crest-derived corneal fibroblast precursor cells are surrounded by distinct extracellular matrices which change both…

Tags: *Extracellular Matrix, 1996, Animals, Birk D E, Cell Differentiation, Chick Embryo, Collagen/biosynthesis, Cornea/chemistry/*embryology/metabolism, Doane K J, Experimental eye research, Eye Proteins/analysis, Fibroblasts/cytology, Glycoproteins/analysis, McLaughlin J S, Neural Crest/cytology, Proteoglycans/biosynthesis, Time Factors, Ting W H

L-DOPA modulation of corpus striatal dopamine and dihydroxyphenylacetic acid output from intact and 6-OHDA lesioned rats.

In the present report we examined the differences in in vitro dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) efflux from the corpus striatum (CS) of intact versus 6-hydroxydopamine (6-OHDA) lesioned (in substantia nigra) male rats in response…

Tags: *Sympathectomy, 1996, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Animals, Antiparkinson Agents/*pharmacology, Chemical, Corpus Striatum/drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Journal of neural transmission (Vienna, Austria : 1996), Levodopa/*pharmacology, Male, Oxidopamine, Rats, Sprague-Dawley, Substantia Nigra/drug effects/metabolism, Xu K

Three-dimensional ultrasound.

Laparoendoscopic surgery is fueled by technology, and advances in medical imaging may bring about further progress. The application of three-dimensional ultrasound to minimally invasive surgery represents technology "just over the horizon." This…

Tags: 1996, Cost-Benefit Analysis, Data Display, Humans, Interventional/economics/methods, Kavic M S, Laparoscopy, Medical Laboratory Science/economics/methods, Minimally Invasive Surgical Procedures, Surgical endoscopy, Ultrasonography, Ultrasonography/economics/*methods

Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice.

We have recently reported that treatment of gonadectomized female and male C57/B1 mice with the gonadal steroid hormone, estrogen, reduced nigrostriatal dopaminergic neurotoxicity resulting from the Parkinson's-like inducing agent

Olfactory bulbectomy disrupts the expression of cocaine-induced conditioned place preference.

The role of the olfactory sense in the expression of cocaine-induced conditioned place preference (CPP) was examined in adult male rats (n = 35) of the N/Nih strain. Consistent with the scientific literature, rats were observed to significantly (p…

Age-related changes in monoamines within the olfactory bulbs of the Fischer 344 male rat.

In this report the olfactory bulbs (OB) were removed from 5-6 month, 15-16 month and 25-26 month male Fischer 344 rats and assayed for concentrations of monoamines and their metabolites using HPLC-EC. Concentrations of norepinephrine were…

Tags: 1996, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Aging/*metabolism, Animals, Biogenic Monoamines/*metabolism, Dluzen D E, Dopamine/metabolism, Inbred F344, Male, Mechanisms of ageing and development, Olfactory Bulb/*metabolism, Rats, Serotonin/metabolism

Cocaethylene-induced kindling of seizure effects: cross-specificity with cocaine.

Sensitization and cross-sensitization to the seizurogenic effects of cocaine and cocaethylene were examined in the HS strain of mice. Animals were administered IP injections of either 48 mg/kg cocaine or 32 mg/kg cocaethylene once per day for 4 days.…

Tags: 1996, Animals, Cocaine/*analogs & derivatives/pharmacology, Convulsants/*pharmacology, Dopamine Uptake Inhibitors/*pharmacology, Drug Interactions, Epilepsy, Female, Inbred Strains, Kindling, Male, Meehan S M, Mice, Neurologic/*drug effects, Pharmacology, biochemistry, and behavior, Schechter M D, Seizures/*chemically induced, Status Epilepticus/chemically induced, Tonic-Clonic/chemically induced

Prenatal cocaine exposure leads to enhanced long-term potentiation in region CA1 of hippocampus.

Cocaine use by pregnant women is currently of concern for its social and economic impact. Clinical studies of cocaine exposed offspring are limited by methodological constraints. In this study we used a rabbit model to examine the effects of…

Tags: *Prenatal Exposure Delayed Effects, 1996, Animals, Brain research. Developmental brain research, Cocaine/*administration & dosage/pharmacology, Electrophysiology, Female, Hippocampus/*drug effects/physiology, In Vitro Techniques, Little J Z, Long-Term Potentiation/*drug effects, Narcotics/*administration & dosage/pharmacology, Neuronal Plasticity/drug effects, Pregnancy, Rabbits, Reference Values, Synapses/drug effects, Teyler T J

Discriminative stimulus properties of CGS 10746B: similarity to dopamine D1 receptor antagonists.

CGS 10746B is an imidazole-derivative related to the atypical antipsychotic clozapine which produces a decrease in dopamine release without altering dopamine metabolism or occupying D2 receptors. Rats were trained on an appetitively-motivated,…

In utero cocaine exposure decreases dopamine D1 receptor modulation of hippocampal long-term potentiation in the rabbit.

Cocaine increases the synaptic concentration of neurotransmitters by inhibiting catecholamine transporters. Disturbances of behavior and cellular physiology have been associated with prenatal cocaine exposure and are related to changes in dopamine…

Tags: 1996, Animals, Cocaine/*pharmacology, Dopamine D1/*drug effects, Female, Hippocampus/*drug effects, Little J Z, Long-Term Potentiation/*drug effects, Neuroscience letters, Rabbits, Receptors, Teyler T J, Uterus/*drug effects

The effects of anticonvulsant drugs on long-term potentiation (LTP) in the rat hippocampus.

In hippocampal CA1 area, there are at least two forms of long-term potentiation (LTP): one is N-methyl-D-aspartate (NMDA) receptor-dependent LTP (NMDA LTP), which is induced with a 25 Hz tetanus and blocked by 50 microM

Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57/B1 mice.

Castrated retired breeder male and female mice were treated or not with a 17 beta-estradiol pellet. At 10 days postcastration +/- estrogen treatment all animals were treated with MPTP. Five days later, concentrations of dopamine were determined from…

Variation in quantitative measures of enamel prisms from different species as assessed using confocal microscopy.

This study presents a statistical analysis of variability in six measures of enamel prism and ameloblast size and spacing gathered using confocal microscopy, and applies the results to a consideration of appropriate sampling strategies for taxonomic…

Tags: 1996, Animals, Archives of oral biology, Chiroptera/anatomy & histology, Confocal, Crystallography, Dental Enamel/*ultrastructure, Dumont E R, Electron, Galago/anatomy & histology, Insectivora/anatomy & histology, Lemur/anatomy & histology, Lemuridae/anatomy & histology, Mammals/*anatomy & histology, Microscopy, Primates/anatomy & histology, Scanning, Species Specificity

Acute appendicitis presenting as a perinephric abscess.

Tags: 1996, Abscess/*etiology, Acute Disease, Appendicitis/*complications, Bologna R A, Danesis G G, Humans, Khoudary K P, Kidney Diseases/*etiology, Male, Middle Aged, Porter J A, Summers J L, The Journal of urology

Phentermine+fenfluramine produce cocaine-like discriminative cues.

Drug discrimination studies were conducted in six male Sprague-Dawley rats trained to discriminate the interoceptive cues produced by 10 mg/kg cocaine in an effort to investigate if there is stimulus generalization to phentermine or phentermine +…

Tags: *Discrimination (Psychology), 1996, Animals, Cocaine/*pharmacology, Department of Anatomy & Neurobiology, Dose-Response Relationship, Drug, Fenfluramine/administration & dosage/*pharmacology, Life sciences, Male, McBurney D, NEOMED College of Medicine, Phentermine/administration & dosage/*pharmacology, Rats, Schechter M D, Sprague-Dawley

Diabetes reduces growth and body composition more in male than in female rats.

Food restriction and/or starvation has a consistently greater and more permanent effect on physical growth in males than in females. Because diabetes may be viewed as being analogous to starvation, we tested the hypothesis that diabetes would reduce…

Flow cytometric and ultrastructural aspects of the synergistic antitumor activity of vitamin C-vitamin K3 combinations against human prostatic carcinoma cells.

Transmission and scanning electron microscopy and flow cytometry were employed to characterize the cytotoxic effects of vitamin C (VC), vitamin K3 (VK3), or VC-VK3 combinations on a human prostate carcinoma cell line (DU145) following a 1-h vitamin…

The formation of cocaethylene and clinical presentation of ED patients testing positive for the use of cocaine and ethanol.

The purpose of this investigation was to document the clinical presentation of emergency department (ED) patients who tested positive for concurrent cocaine (COC) and ethanol (EtOH) use and the incidence of cocaethylene (CE) formation in this study…

Response error in self-reported current smoking frequency by black and white established smokers.

As compared with white smokers, black smokers, although they report using fewer cigarettes per day, are at higher risk for most smoking-related diseases. Among black smokers serum cotinine levels are also higher in proportion to cigarettes per day;…

Tags: *African Americans, *European Continental Ancestry Group, 1996, Adult, Analysis of Variance, Annals of epidemiology, Bias, Clark P I, Cotinine/*analysis, Female, Gautam S P, Gerson L W, Hlaing W M, Humans, Incidence, Male, Reproducibility of Results, Smoking/*epidemiology/ethnology, Surveys and Questionnaires

Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release.

The effects of estrogen on MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in C57Bl and CD-1 mice. Ovariectomized mice with and without estrogen were treated with MPTP or its vehicle. The effects of these treatments…

Tags: *MPTP Poisoning, 1996, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animals, Corpus Striatum/*drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Estradiol/*pharmacology, Female, Inbred C57BL, Inbred Strains, Journal of neurochemistry, Levodopa/pharmacology, Liu B, McDermott J L, Mice, Osmolar Concentration, Ovariectomy

Norepinephrine is lateralized within the olfactory bulbs of male mice.

Concentrations and in vitro release of norepinephrine were determined from left and right olfactory bulbs of adult male CD-1 mice. Norepinephrine concentrations from the left olfactory bulbs were significantly greater than those of the right (p…

Tags: *Functional Laterality, *Sex Characteristics, 1996, Animals, Dluzen D E, Dopamine/metabolism, Inbred Strains, Journal of neurochemistry, Kreutzberg J D, Male, Mice, Norepinephrine/*metabolism, Olfactory Bulb/*metabolism, Osmolar Concentration, Potassium/pharmacology, Tissue Distribution

Common eye disorders: six patients to refer.

Thorough ocular history taking and physical examination are essential to establish a diagnosis in patients presenting with eye conditions. Some conditions require ophthalmologic referral to avoid serious complications and even vision loss. These…

Tags: 1996, Adult, Aged, Angle-Closure/diagnosis/therapy, Corneal Ulcer/diagnosis/therapy, Eye Diseases/*diagnosis/*therapy, Female, Glaucoma, Humans, Iritis/diagnosis/therapy, Male, Postgraduate medicine, Referral and Consultation, Retinal Artery Occlusion/diagnosis/therapy, Retinal Detachment/diagnosis/therapy, Weinstock F J, Weinstock M B

Common eye disorders: six patients to treat, pitfalls to avoid.

Primary care physicians have an important role in diagnosing and treating eye disorders–including dacryocystitis, blepharitis, and conjunctivitis–and in determining when ophthalmologic referral is needed. Fundus examination for diagnosis of glaucoma…

Tags: 1996, Adolescent, Adult, Allergic/drug therapy, Bacterial/drug therapy, Blepharitis/therapy, Conjunctivitis, Dacryocystitis/therapy, Eye Diseases/*diagnosis/*therapy, Eye Foreign Bodies/diagnosis, Female, Humans, Infant, Male, Postgraduate medicine, Viral/therapy, Weinstock F J, Weinstock M B

Can aggressive treatment of diabetic foot infections reduce the need for above-ankle amputation?

We retrospectively evaluated the charts of 112 patients with diabetic foot infection to determine if early aggressive surgical intervention improves outcome. All patients were classified into two groups on the basis of the timing of surgical…

Immune response to nonspecific and altered tissue antigens in soft tissue allografts.

Soft tissue allografts have many uses in orthopaedic surgery, including knee ligament reconstruction, hand tendon surgery, shoulder instability, and rotator cuff reconstruction. The predictable biologic incorporation of soft tissue allografts without…

Onset of exercise increases lumbar sympathetic nerve activity in rats.

We hypothesized that lumbar sympathetic nerve activity (LSNA) increases at the onset of whole-body dynamic exercise in the rat. To test this hypothesis, we recorded LSNA, heart rate (HR), and arterial pressure (AP) at rest and during a graded…

Tags: 1996, Animal/*physiology, Animals, Blood Pressure, Chen C Y, Collins H L, DiCarlo S E, Heart Rate, Lumbar Vertebrae/*innervation, Medicine and science in sports and exercise, Physical Conditioning, Rats, Sympathetic Nervous System/*physiology

Tags: 1996, Action Potentials/physiology, Animals, Coussens C M, Electric Stimulation/methods, Excitatory Postsynaptic Potentials/physiology, In Vitro Techniques, Learning & memory (Cold Spring Harbor, N.Y.), Long-Evans, Long-Term Potentiation/*physiology, Neuronal Plasticity/*physiology, Rats, Synapses/*physiology, Teyler T J

Browse Items (176 total)