Browse Items · NEOMED Bibliography Database

Cocaethylene produces conditioned place preference in rats.

The ability of cocaethylene to produce either a conditioned place preference or a conditioned place aversion was tested in rats. Twelve male rats were administered 10 mg/kg cocaethylene and confined to their nonpreferred side of the conditioned place…

Tags: 1995, Animals, Avoidance Learning/drug effects, Cocaine/*analogs & derivatives/pharmacology, Conditioning, Discrimination (Psychology)/drug effects, Male, Motor Activity/*drug effects, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Sprague-Dawley

Cocaethylene produces discriminative stimulus properties in the rat: effect of cocaine and ethanol coadministration.

Experimentally naive Sprague-Dawley male rats were trained to discriminate the interoceptive stimulus cues produced by either 10.0 mg/kg cocaine or 10.0 mg/kg cocaethylene from their saline vehicles. Although it required more sessions to train the…

Tags: 1995, Animals, Cocaine/*analogs & derivatives/pharmacokinetics/*pharmacology, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Ethanol/pharmacokinetics/*pharmacology, Male, Pharmacology, biochemistry, and behavior, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley

Cocaine discrimination is attenuated by isradipine and CGS 10746B.

The discriminative stimulus properties of cocaine are thought to be mediated by dopaminergic mechanisms that may be modulated by calcium ion influx and/or interact with 5-hydroxytryptamine3 (5-HT3) receptors. To test these possibilities, rats were…

Comparative binding of biotinylated neurotrophins to alpha(2)-macroglobulin family of proteins: relationship between cytokine-binding and neuro-modulatory activities of the macroglobulins.

Human alpha(2)-macroglobulin (alpha(2)M), pregnancy zone protein (PZP), rat alpha(1)M and acute-phase rat alpha(2)M belong to the alpha(2)M gene family of proteins, which can react covalently with nucleophilic monoamines to yield monoamine-activated…

Comparative binding of neurotrophins (NT-3, CNTF and NGF) and various cytokines to alpha 2-macroglobulin.

All the nine common cytokines in this study (including NT-3, IGF-1, CNTF and

Comparison of anorectic drugs in rats trained to discriminate between satiation and deprivation.

Eight male rats were trained to discriminate between the internal states produced by food deprivation of 3 hours (satiation) and that produced by food deprivation of 27 hours duration (deprivation). One lever, in a two-lever operant chamber, had to…

Tags: *Food Deprivation, 1990, Amphetamine/*pharmacology, Analysis of Variance, Animals, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Fenfluramine/*analogs & derivatives/*pharmacology, Inbred Strains, Life sciences, Male, Norfenfluramine/*pharmacology, Rats, Satiation/*drug effects, Schechter M D

Comparison of the behavioral effects of ibogaine from three sources: mediation of discriminative activity.

Ibogaine is an alkaloid employed for its hallucinatory properties in West Central Africa which has been the subject of alleged efficacy as an aid in the interruption and treatment of chemical dependency. The major sources of the Schedule I agent are:…

Tags: *Discrimination (Psychology), 1993, Animal/*drug effects, Animals, Behavior, Dose-Response Relationship, Drug, European journal of pharmacology, Gordon T L, Ibogaine/*pharmacology, Male, Rats, Schechter M D, Serotonin Receptor Agonists/pharmacology, Sprague-Dawley

Conditioned place aversion following the central administration of a novel dopamine release inhibitor CGS 10746B.

Numerous drugs of abuse that elevate brain extracellular dopamine concentrations by either increasing the firing rate of dopaminergic neurons or producing dopamine release have been shown to reliably condition a preference for place. If dopamine…

Tags: 1991, Animals, Antipsychotic Agents/administration & dosage/*pharmacology, Avoidance Learning/*drug effects, Calcagnetti D J, Dopamine/*metabolism, Inbred Strains, Injections, Intraventricular, Male, Motor Activity/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/administration & dosage/*pharmacology

Conditioned place aversion produced by dopamine release inhibition.

CGS 10746B, a dopamine release inhibitor with properties similar to the atypical antipsychotic clozapine, was assessed as to its behavioral properties using spontaneous locomotor activity and the conditioned place preference test. Rats conditioned…

Conditioned place preference produced by the psychostimulant cathinone.

Previous work has indicated that the psychostimulant cathinone produces a location preference in the conditioned place preference task. The present study expanded upon this earlier work by examining the dose-response nature of cathinone-induced…

Tags: 1993, Alkaloids/administration & dosage/*pharmacology, Animals, Central Nervous System Stimulants/administration & dosage/*pharmacology, Choice Behavior/drug effects, Conditioning (Psychology)/drug effects, Dose-Response Relationship, Drug, European journal of pharmacology, Habituation, Male, Meehan S M, Motor Activity/*drug effects, Psychophysiologic, Rats, Schechter M D, Sprague-Dawley

Conditioned place preference/aversion to fenfluramine in fawn hooded and sprague-Dawley rats.

The Fawn Hooded (FH) rat strain possesses a genetic platelet storage pool deficiency which leads to an impaired capacity for platelets to store and release serotonin. While the relationship between this deficit and possible alterations in brain…

Tags: 1994, Animals, Avoidance Learning/*drug effects, Blood Platelets/metabolism, Brain Chemistry/genetics, Fenfluramine/*pharmacology, Habituation, Inbred Strains, Meehan S M, Platelet Storage Pool Deficiency/physiopathology, Progress in neuro-psychopharmacology & biological psychiatry, Psychophysiologic/drug effects, Rats, Schechter M D, Serotonin/metabolism/physiology, Species Specificity, Sprague-Dawley

Congenital diaphragmatic hernia prevents absorption of distal air space fluid in late-gestation rat fetuses.

We hypothesized that congenital diaphragmatic hernia (CDH) may decrease distal air space fluid absorption due to immaturity of alveolar epithelial cells from a loss of the normal epithelial Na+ transport, as assessed by amiloride and epithelial Na+…

Coordinate down-regulation of cartilage matrix gene expression in Bcl-2 deficient chondrocytes is associated with decreased SOX9 expression and decreased mRNA stability.

The anti-apoptotic protein Bcl-2 has been shown to function in roles unrelated to apoptosis in a variety of cell types. We have previously reported that loss of Bcl-2 expression alters chondrocyte morphology and modulates aggrecan expression via an…

Daily exercise and gender influence arterial baroreflex regulation of heart rate and nerve activity.

The influence of daily spontaneous running (DSR) and gender on the arterial baroreflex regulation of heart rate (HR) and lumbar sympathetic nerve activity (LSNA) was examined in 13 male [7 sedentary (SED) and 6 DSR] and 12 female (6 SED and 6 DSR)…

Tags: *Physical Conditioning, *Sex Characteristics, 1996, Animal, Animals, Arteries/*physiology, Baroreflex/*physiology, Chen C Y, DiCarlo S E, Female, Heart Rate/*physiology, Lumbosacral Region, Male, Rats, Rest, Sprague-Dawley, Sympathetic Nervous System/*physiology, The American journal of physiology

Daily exercise and gender influence postexercise cardiac autonomic responses in hypertensive rats.

The influence of daily spontaneous running (DSR) and gender on postexercise cardiac autonomic responses was examined in spontaneously hypertensive rats. Rats were weaned at 4-5 wk of age and were randomly assigned to a sedentary (7 males and 6…

Daily exercise attenuates the sympathetic component of the arterial baroreflex control of heart rate.

The influence of daily spontaneous running (DSR) on the sympathetic (SC) and parasympathetic components of the arterial baroreflex control of heart rate (HR) was examined in 16 female Long Evans rats [8 sedentary (SED) and 8 DSR]. After

Daily exercise improved blood pressure homeostasis of rats subjected to surgical stress.

The effect of daily spontaneous running on blood pressure homeostasis (BPH) was evaluated in 19 male and 13 female control rats and 7 male and 13 female daily spontaneous running rats subjected to surgery and subsequent repetitive hemodynamic…

Tags: *Blood Pressure, *Homeostasis, *Physical Conditioning, 1994, Animal, Animals, DiCarlo S E, Female, Jarjoura D G, Journal of applied physiology (Bethesda, Md. : 1985), Male, Operative/*adverse effects, Physiological/*etiology/*physiopathology, Rats, Running, Scislo T J, Sprague-Dawley, Stress, Surgical Procedures

Daily exercise reduces fat, protein and body mass in male but not female rats.

This study was designed to compare the estimated energy balance, linear growth (body and bone lengths) and body composition (all components including body mass, total body water, fat, protein and ash) response to daily spontaneous running (DSR) in…

Daily spontaneous running alters behavioral and neurochemical indexes of nigrostriatal function.

Behavioral and neurochemical indexes of nigrostriatal dopaminergic function were compared between sedentary control rats (n = 12) and daily spontaneous running (DSR) male rats (n = 10). Nine weeks of DSR did not significantly alter body, heart,…

Daily spontaneous running attenuated the central gain of the arterial baroreflex.

Exercise training attenuates arterial baroreflex function. Mechanisms responsible may include an attenuated aortic baroreceptor reactivity (afferent mechanisms) and/or an attenuated central baroreflex gain. We tested the hypothesis that the aortic…

Tags: 1995, Animal, Animals, Arteries/*physiology, Baroreflex/*physiology, Brain/*physiology, Chen C Y, DiCarlo S E, Female, Male, Motor Activity/*physiology, Physical Conditioning, Rats, Scislo T J, Sprague-Dawley, The American journal of physiology

Daily spontaneous running did not alter vagal afferent reactivity.

Exercise training alters the cardiopulmonary baroreflex regulation of the circulation; however, the mechanisms responsible are unknown. One possibility is an enhanced afferent response to cardiopulmonary stimulation. We therefore tested the…

Deficits in shock-induced freezing and naltrexone enhancement of freezing in fawn hooded rats.

When a rat is returned to a context associated with mild electric foot shock (1 mA/0.75 s), the environmental cues elicit a species-specific defensive behavior termed freezing. Genetically divergent strains of rats given identical shock conditioning…

Tags: *Fear, 1994, Animals, Brain research bulletin, Calcagnetti D J, Classical/*drug effects, Conditioning, Electroshock, Female, Inbred Strains, Naltrexone/*pharmacology, Rats, Schechter M D

Depletion of olfactory bulb norepinephrine by 6-OHDA disrupts chemical cue but not social recognition responses in male rats.

In the present experiment, 6-OHDA was infused directly into the olfactory bulb (OB) to produce a localized neurotoxic lesion. Habituation/dishabituation behavioral tests were then conducted to measure recognition responses to chemical cues (urine as…

Depotentiation of vdccLTP requires NMDAR activation.

Long-term potentiation is an enduring increase in synaptic efficacy following repeated stimulation of afferent fibers that is thought to underlie memory. In area CA1 of the hippocampus at least two forms of synaptic potentiation coexist at the same…

Development of habituation in the dentate gyrus of rat: physiology and anatomy.

The physiological development of monosynaptic response habituation in the rat dentate gyrus was compared to morphological development. Rapid Golgi techniques were coupled with in vitro studies of dentate granule cell habituation to several…

Tags: 1978, Animals, Brain research bulletin, Duffy C J, Female, Habituation, Hippocampus/anatomy & histology/physiology, Inbred Strains, Male, Psychophysiologic/*physiology, Rats, Synapses/physiology, Teyler T J

Development of inhibitory and excitatory synaptic transmission in the rat dentate gyrus.

We studied the ontogeny of inhibitory and excitatory processes in the rat dentate gyrus by examining paired-pulse plasticity in the hippocampal slice preparation. The mature dentate gyrus produces characteristic paired-pulse responses across a wide…

Tags: 1994, Action Potentials, Animals, DiScenna P G, Hippocampus, Hippocampus/*growth & development, Neuronal Plasticity/*physiology, Rats, Reaction Time, Synapses/physiology, Teyler T J

Development of potentiation in the dentate gyrus of rat: physiology and anatomy.

The physiological development of potentiating processes in the rat dentate gyrus were compared to morphological development. Rapid Golgi techniques were coupled with in vitro studies of dentate granule cell frequency potentiation, post-tetanic…

Tags: 1978, Animals, Brain research bulletin, Duffy C J, Female, Hippocampus/anatomy & histology/growth & development/*physiology, In Vitro Techniques, Inbred Strains, Male, Rats, Teyler T J

Developmental alterations in N-methyl-D-aspartate stimulated [3H]norepinephrine release in rat brain cortex and hippocampus.

Developmental alterations in N-methyl-D-aspartate (NMDA)-stimulated[3H]norepinephrine release from rat brain cortical and hippocampal slices were studied. NMDA (10-1000 microM) resulted in a concentration-dependent increase in [3H]norepinephrine…

Tags: 1993, 2-Amino-5-phosphonovalerate/pharmacology, Animals, Brown L M, Cerebral Cortex/drug effects/*growth & development/metabolism, Female, Hippocampus/drug effects/*growth & development/metabolism, In Vitro Techniques, Male, N-Methylaspartate/*pharmacology, Neuroscience letters, Norepinephrine/*metabolism, Rats, Sprague-Dawley

Developmental changes in levels of growth hormone mRNA in Zucker rats.

Levels of pituitary growth hormone (GH) messenger RNA (mRNA) were compared in groups of genetically obese (fa/fa) and lean (Fa/-) littermate male Zucker rats at four different ages, 3, 5, 9, and 11 weeks, in order to determine the earliest age at…

Dewetting based fabrication of fibrous micro-scaffolds as potential injectable cell carriers.

Although regenerative medicine utilizing tissue scaffolds has made enormous strides in recent years, many constraints still hamper their effectiveness. A limitation of many scaffolds is that they form surface patches, which are not particularly…

Diabetes reduces growth and body composition more in male than in female rats.

Food restriction and/or starvation has a consistently greater and more permanent effect on physical growth in males than in females. Because diabetes may be viewed as being analogous to starvation, we tested the hypothesis that diabetes would reduce…

Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats.

Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place…

Tags: 1992, Animals, Avoidance Learning/*drug effects, Conditioning, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Krimmer E C, Motor Activity/drug effects, Operant/drug effects, Psychopharmacology, Rats, Schechter M D, Sleep/drug effects, Species Specificity

Differential effects of nicotine but not cathinone on motor activity of P and NP rats.

The locomotor stimulatory effects of nicotine (0.4 and 0.8 mg/kg) and cathinone (0.5 and 1.0 mg/kg) were assessed in alcohol-preferring (P) and -nonpreferring (NP) rats. Whereas P rats demonstrated enhanced (0.8 mg/kg) or no change (0.4 mg/kg) in…

Tags: 1993, Alcohol Drinking/*psychology, Alkaloids/*pharmacology, Animals, Dextroamphetamine/pharmacology, Discrimination (Psychology)/drug effects, Genotype, Gordon T L, Male, Meehan S M, Motor Activity/*drug effects, Nicotine/*pharmacology, Pharmacology, biochemistry, and behavior, Psychotropic Drugs/*pharmacology, Rats, Schechter M D

Differential training sequence effect upon psychostimulant discrimination.

1. Previous studies indicate that rats trained to discriminate either cathinone or cathine from its vehicle have a diminished discriminative performance when tested 24 hours after a drug administration when compared to tests conducted after a vehicle…

Tags: 1993, Alkaloids/pharmacology, Animals, Appetite Depressants/pharmacology, Central Nervous System Stimulants/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Food, Male, Phenylpropanolamine/pharmacology, Progress in neuro-psychopharmacology & biological psychiatry, Psychotropic Drugs/pharmacology, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley

Direct microinjection of cathinone into the rat brain produces discriminative stimuli.

Rats were trained to discriminate IP administration of 800 micrograms/kg cathinone using a food-motivated, two-lever discrimination procedure. Following training, 800 micrograms/kg cathinone discrimination was produced (generalized) by lower…

Discrete versus cumulative dosing in dose-response discrimination studies.

This study describes the results of a 'side-by-side' comparison of two measurement techniques and two dosing regimens in a discrimination study using rats trained to either 10 mg/kg cocaine or 2 mg/kg 3,4-methylenedioxymethamphetamine (MDMA). The…

Tags: 1997, 4-methylenedioxyamphetamine/*pharmacology, Animals, Chemical, Cocaine/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Evaluation, European journal of pharmacology, Male, N-Methyl-3, Preclinical, Rats, Schechter M D, Sprague-Dawley, Stimulation

Tags: 1988, Animals, Appetite Depressants/*pharmacology, Avoidance Learning/drug effects, Carbolines/*pharmacology, Discrimination Learning/*drug effects, Generalization, Inbred Strains, Leidenheimer N J, Male, Pharmacology, biochemistry, and behavior, Physiological/*psychology, Rats, Schechter M D, Stimulus/*drug effects, Stress

Browse Items (424 total)