Browse Items · NEOMED Bibliography Database

Physiological Indices of Stress Prior to and Following Total Knee Arthroplasty Predict the Occurrence of Severe Post-Operative Pain.

OBJECTIVE: The severe pain and disability associated with osteoarthritis often motivate individuals to undergo arthroplastic surgery. However, a significant number of surgical patients continue to experience pain following surgery. Prior research has…

Tags: *Cardiovascular, *Cortisol, *Epinephrine, *Post-operative Pain, *Severity of Illness Index, *Stress, *Surgery, 2016, 80 and over, Aged, Arthroplasty, Catecholamines – Urine, Center for Epidemiological Studies Depression Scale, Cohort Studies, Cremeans-Smith Julie K, Data Analysis Software, Delahanty Douglas L, Descriptive Statistics, Effect Size, Female, Greene Kenneth, Human, Humans, Hydrocortisone – Urine, Knee, Knee/*adverse effects/psychology, Male, Middle Age, Middle Aged, Nonexperimental Studies, Ohio, Pain, Pain Measurement/methods, Pain medicine (Malden, Mass.), Physiological, Postoperative Pain – Risk Factors, Postoperative/*diagnosis/etiology/*psychology, Predictive Value of Tests, Prospective Studies, Psychological/complications/*diagnosis/*psychology, Regression, Replacement, Scales, Stress, Summated Rating Scaling, Treatment Outcome

Trauma history as a resilience factor for patients recovering from total knee replacement surgery.

Research concerning the impact of trauma history on individuals' ability to cope with subsequent events is mixed. While many studies find that trauma history increases vulnerability for conditions such as post-traumatic stress disorder and chronic…

Tags: 2015, 80 and over, Aged, Arthroplasty, Bivariate Statistics, Center for Epidemiological Studies Depression Scale, Clinical Assessment Tools, Coefficient Alpha, Convalescence, CORRELATION (Statistics), Cremeans-Smith Julie K, Delahanty Douglas L, Descriptive Statistics, Effect Size, EFFECT sizes (Statistics), Female, Functional Status, Funding Source, Greene Kenneth, Hardiness, Human, Impact of Events Scale, Knee – Psychosocial Factors, Knee – Rehabilitation, Life Change Events, LIFE skills, Male, Middle Age, Ohio, Pain Measurement, Post-Traumatic, POST-traumatic stress disorder, Psychological, Psychological Tests, Psychology & Health, recovery, Rehabilitation, Replacement, RESEARCH funding, RESILIENCE (Personality trait), Risk Factors, Scales, Statistics, Stress, STRESS (Psychology), Stress Disorders, T-test (Statistics), T-Tests, total knee replacement, TOTAL knee replacement – Psychological aspects, trauma, TREATMENT effectiveness, Treatment Outcomes, WOUNDS & injuries

Predicting symptoms of post-traumatic stress among patients undergoing orthopedic surgery on the basis of routinely collected cardiovascular data.

Rhodotorula minuta: an unusual fungal infection in hip-joint prosthesis.

Fungal infections of total joint arthroplasty are uncommon complications, and most cases have been associated with Candida species. In this article, we present a case in which a total hip arthroplasty was infected with Rhodotorula minuta.…

Reduction mammaplasty: an outcome analysis.

Reduction mammaplasty is usually performed to relieve painful symptoms and physical signs of macromastia. Justification for reduction mammaplasty should be based on the probability of relieving these clinical signs and symptoms. This retrospective…

Tags: *Mammaplasty/adverse effects, 1995, Adolescent, Adult, Aged, Annals of plastic surgery, Dabbah A, Fat Necrosis/etiology, Female, Humans, Lehman J A Jr, Middle Aged, Parker M G, Retrospective Studies, Tantri D, Treatment Outcome, Wagner D S

Final Two-Year Outcomes for the Sentry Bioconvertible Inferior Vena Cava Filter in Patients Requiring Temporary Protection from Pulmonary Embolism.

PURPOSE: To report final 2-year outcomes with the Sentry bioconvertible inferior vena cava (IVC) filter in patients requiring temporary protection against pulmonary embolism (PE). MATERIALS AND METHODS: In a prospective multicenter trial, the…

Two-portal endoscopic carpal tunnel release: an outcome analysis of 333 hands.

Outcome data were collected on 239 patients who underwent endoscopic release of the transverse carpal ligament. The procedure was performed on 333 hands in 239 patients. All patients had failed to respond to nonoperative management for carpal tunnel…

Tags: 1998, 80 and over, Adult, Aged, Annals of plastic surgery, Carpal Tunnel Syndrome/physiopathology/*surgery, Davies B W, Endoscopy/*methods, Female, Fritz A M, Humans, Male, Middle Aged, Pennington G A, Treatment Outcome

Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress.

KEY POINTS: Hyperammonaemia occurs in hepatic, cardiac and pulmonary diseases with increased muscle concentration of ammonia. We found that ammonia results in reduced skeletal muscle mitochondrial respiration, electron transport chain complex I…

Tags: *ammonia, *ATP, *cellular respiration, *cirrhosis, *Mitochondria, *Oxidative Stress, *portacaval anastamosis, *Reactive oxygen species, *skeletal muscle, 2016, Adenosine Triphosphate/metabolism, Aged, Allawy Allawy, Animals, Cell Line, Cell Respiration, Creatine Kinase/metabolism, Dasarathy Srinivasan, Davuluri Gangarao, Department of Pharmaceutical Sciences, Female, Flask Chris A, Hoppel Charles, Humans, Hyperammonemia/*metabolism, Kasumov Takhar, Kumar Avinash, Liver Cirrhosis/metabolism, Male, Middle Aged, Mitochondria, Muscle, Muscle/*metabolism, Myosin Heavy Chains/metabolism, NAD/metabolism, NEOMED College of Pharmacy, Rats, Reactive Oxygen Species/metabolism, Rennison Julie H, Sandlers Yana, Singh Dharmvir, Skeletal/*metabolism, Sprague-Dawley, Thapaliya Samjhana, The Journal of physiology, Thiobarbituric Acid Reactive Substances/metabolism, Van Wagoner David R

Scalp Angiosarcoma Remission with Bevacizumab and Radiotherapy without Surgery: A Case Report and Review of the Literature.

Angiosarcoma (AS) is a rare and aggressive vascular neoplasm with very poor prognosis. Patients with extensive cutaneous AS who are not surgical candidates have very limited options since there is no standard treatment. Treatment options include…

Gastric epithelial polyps. A 10-year study.

We have reviewed the 10-year experience of a community teaching hospital with gastric epithelial polyps and have analyzed 121 polyps removed from 35 patients. Hyperplastic polyps constituted nearly 75% of the polyps examined; fundic gland polyps…

Tags: 1989, 80 and over, Adult, Aged, Deppisch L M, Female, Humans, Journal of clinical gastroenterology, Male, Middle Aged, Polyps/*pathology/surgery, Retrospective Studies, Rona V T, Sex Factors, Stomach Neoplasms/*pathology/surgery

Effect of Precompression on the Power Doppler Assessment of Breast Lesion Vascularity.

OBJECTIVES: To evaluate the effect of precompression on power Doppler visualization of blood flow in breast masses. METHODS: This Institutional Review Board-approved and Health Insurance Portability and Accountability Act-compliant study evaluated 30…

Predictors of mortality for nursing home-acquired pneumonia: a systematic review.

BACKGROUND: Current risk stratification tools, primarily used for CAP, are suboptimal in predicting nursing home acquired pneumonia (NHAP) outcome and mortality. We conducted a systematic review to evaluate current evidence on the usefulness of…

Survey of cadaveric donors to a body donation program: 1978-1993.

Body donation files from the Department of Anatomy at Northeastern Ohio Universities College of Medicine were reviewed from the 569 donors used in our program from 1978-1993. The data were entered into a computerized database to evaluate the…

The Effect Of Long-term Treatment With Deprenyl On Basal And L-dopa Evoked Dopamine Release Invitro From The Corpus Striatum Of Aged Rats

Tags: (-)deprenyl, 1991, Aged, amphetamine, Brain, corpus striatum, Dluzen D E, dopac, Dopamine, Journal of Neural Transmission-General Section, l-dopa, life, McDermott J L, Neurosciences & Neurology, parkinsons-disease

Hand hygiene and face touching in family medicine offices: a Cincinnati Area Research and Improvement Group (CARInG) network study.

BACKGROUND: Family medicine offices may play an important role in the transmission of common illnesses such as upper respiratory tract infections (URTIs). There has, however, been little study of whether physicians teach patients about URTI…

Ten-year outcomes: the clinical utility of single photon emission computed tomography/computed tomography capromab pendetide (Prostascint) in a cohort diagnosed with localized prostate cancer.

Purpose: To evaluate the clinical utility of capromab pendetide imaging with single photon emission computed tomography coregistration with computed tomography (SPECT/CT) in primary prostate cancer (CaP) for pretreatment prognostic staging and…

Barrett's esophagus: an acquired condition with genetic predisposition.

We describe four families with a strong familial expression of Barrett's/gastroesophageal reflux disease (GERD) complex spanning one to four generations with two to seven affected members per family. The purpose of this report is to highlight genetic…

Tags: 1993, Adenocarcinoma/genetics, Aged, Barrett Esophagus/*genetics/pathology, Biopsy, Dominant, Esophageal Neoplasms/genetics, Esophagus/pathology, Fahmy N, Female, Gastroesophageal Reflux/*genetics, Genes, Humans, King J F, Male, Middle Aged, Pedigree, The American journal of gastroenterology

Laparoscopic cytoreduction for primary advanced ovarian cancer.

INTRODUCTION: We evaluated the feasibility of laparoscopic cytoreduction for primary advanced ovarian cancer. METHODS: All patients with presumed stage 3/4 primary ovarian cancer underwent attempted laparoscopic cytoreduction. All patients had CT…

Tags: 2010, Aged, Fanning James, Feasibility Studies, Female, Fenton Bradford, Gynecologic Surgical Procedures/*methods, Hojat Rod, Humans, Hysterectomy, Johnson Jil, JSLS : Journal of the Society of Laparoendoscopic Surgeons, Laparoscopy/*methods, Laser Coagulation, Middle Aged, Ovarian Neoplasms/pathology/*surgery, Ovariectomy/*methods, Treatment Outcome

Phase I/II prospective trial of autologous platelet tissue graft in gynecologic surgery.

STUDY OBJECTIVE: To perform the original phase I/II trial of autologous platelet tissue graft in gynecologic surgery to evaluate toxicity and efficacy on decreasing pain. DESIGN: Prospective nonrandomized trial (Canadian Task Force classification…

Feasibility of the Maylard transverse incision for ovarian cancer cytoreductive surgery.

The vast majority of abdominal incisions used in gynecologic surgery are either transverse or vertical midline. The advantages of a vertical midline incision are considered to be rapid abdominal entry and increased exposure to the abdomen and pelvis.…

Tags: 2007, 80 and over, Aged, Fanning James, Feasibility Studies, Female, Flora Robert F, Gynecologic Surgical Procedures/adverse effects/*methods, Humans, Journal of minimally invasive gynecology, Middle Aged, Ovarian Neoplasms/*surgery, Pruett Allison, Reoperation, Tissue Adhesions/*etiology

The epidemiology of respiratory tract infections.

Respiratory tract infections (RTIs) are the most common, and potentially most severe, of infections treated by health care practitioners. Lower RTIs along with influenza, are the most common cause of death by infection in the United States. Risk…

Clinical characteristics of Chlamydia pneumoniae infection as the sole cause of community-acquired pneumonia.

The clinical characteristics of 26 patients with community-acquired pneumonia due to Chlamydia pneumoniae as the only identified pathogen who required hospitalization were evaluated. Most patients (18) had reinfection based on serological results.…

A multicenter, randomized study comparing the efficacy and safety of intravenous and/or oral levofloxacin versus ceftriaxone and/or cefuroxime axetil in treatment of adults with community-acquired pneumonia.

Five hundred ninety patients were enrolled in a prospective, multicenter, randomized trial comparing the efficacy and safety of 7 to 14 days of levofloxacin treatment with that of ceftriaxone and/or cefuroxime axetil in the management of…

Group A streptococcus necrotizing fasciitis.

Necrotizing fasciitis due to Group A streptococcus has been observed with increasing frequency over the past decade. Appropriate management requires rapid recognition of this life-threatening infection and expeditious antimicrobial therapy as well as…

Pneumonia in older adults: reversing the trend.

Tags: 2005, 80 and over, Aged, Department of Internal Medicine, File T M Jr, File Thomas M Jr, Immunization – Trends, JAMA: Journal of the American Medical Association, NEOMED College of Medicine, Pneumonia – Epidemiology – In Old Age, Pneumonia – Risk Factors, Tan J S, Tan James S

Gemifloxacin versus amoxicillin/clavulanate in the treatment of acute exacerbations of chronic bronchitis. The 070 Clinical Study group.

Six hundred patients were evaluated in this randomized, double-blind, double-dummy, multicenter, parallel-group study comparing the efficacy and safety of gemifloxacin (320 mg once-daily for 5 days) and amoxicillin/clavulanate (500/125 mg three-times…

Tags: *Fluoroquinolones, 2000, 80 and over, Acute-Phase Reaction, Adult, Aged, Amoxicillin/pharmacology/therapeutic use, Anti-Infective Agents/adverse effects/pharmacology/*therapeutic use, Bronchitis/*drug therapy, Chronic Disease, Clavulanic Acid/pharmacology/therapeutic use, Combination/pharmacology/*therapeutic use, Department of Internal Medicine, Double-Blind Method, Drug Therapy, Female, File T, Garau J, Gemifloxacin, Haemophilus influenzae/drug effects, Humans, Journal of chemotherapy (Florence, Italy), Lode H, Lynch S, Male, Microbial Sensitivity Tests, Middle Aged, Moraxella (Branhamella) catarrhalis/drug effects, Multicenter Studies as Topic, Naphthyridines/adverse effects/pharmacology/*therapeutic use, NEOMED College of Medicine, Schlemmer B, Streptococcus pneumoniae/drug effects, Treatment Outcome, Young C

Case studies of lower respiratory tract infections: community-acquired pneumonia.

Community-acquired pneumonia (CAP) is a common and potentially serious illness with significant human and economic costs to society. The recent collaborative statement from the Infectious Diseases Society of America (IDSA) and the American Thoracic…

Tags: 2010, Acute – Microbiology, Adult, Adult/microbiology, Aged, Anti-Bacterial Agents/*therapeutic use, Antibiotics – Therapeutic Use, Antitubercular Agents – Therapeutic Use, Antitubercular Agents/therapeutic use, Community-Acquired Infections – Diagnosis, Community-Acquired Infections – Drug Therapy, Community-Acquired Infections/diagnosis/drug therapy, Cough, Cough – Microbiology, Cough/microbiology/virology, Department of Internal Medicine, Diagnosis, Differential, Dyspnea, Fatal Outcome, Female, Fever – Microbiology, Fever/microbiology, File Thomas M Jr, Hemoptysis – Microbiology, Hemoptysis/microbiology, Human, Human – Complications, Human – Diagnosis, Human/complications/*diagnosis, Humans, Hypotension – Microbiology, Hypotension/microbiology, Influenza, Leukopenia – Microbiology, Leukopenia/microbiology, Male, Methicillin-Resistant Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus/*isolation & purification, Miliary/diagnosis/drug therapy, Multiple Organ Dysfunction Syndrome – Microbiology, Multiple Organ Failure/microbiology, Mycobacterium Tuberculosis, Mycobacterium tuberculosis/isolation & purification, NEOMED College of Medicine, Pneumonia – Diagnosis, Pneumonia – Drug Therapy, Pneumonia – Microbiology, Pneumonia – Therapy, Pneumonia/*diagnosis/*drug therapy/microbiology/therapy, Practice Guidelines, Practice Guidelines as Topic, Respiratory Distress Syndrome, Risk Factors, Severity of Illness Index, Severity of Illness Indices, Smoking, Smoking/adverse effects, Staphylococcal Infections – Diagnosis, Staphylococcal Infections – Drug Therapy, Staphylococcal Infections – Microbiology, Staphylococcal Infections – Therapy, Staphylococcal Infections/*diagnosis/*drug therapy/microbiology/therapy, The American journal of medicine, Tuberculosis, Tuberculosis – Diagnosis, Tuberculosis – Drug Therapy

Macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point.

BACKGROUND: Therapy directed against atypical pathogens in patients with community-acquired pneumonia (CAP) is often recommended. This post-hoc analysis evaluated the effect of addition of a macrolide to ceftaroline fosamil or ceftriaxone treatment…

Tags: 2017, 80 and over, Adult, Aged, Anti-Bacterial Agents/adverse effects/*therapeutic use, Atypical pathogen, Bacterial/*drug therapy, Ceftaroline fosamil, Ceftriaxone/adverse effects/*therapeutic use, Cephalosporins/adverse effects/*therapeutic use, Chlamydial Pneumonia, Chlamydophila pneumoniae, Clinical Trials, Combination/adverse effects/methods, Community-Acquired Infections/*drug therapy, Community-acquired pneumonia, Department of Internal Medicine, Double-Blind Method, Drug Therapy, Eckburg Paul B, Female, File Thomas M Jr, Friedland H David, Humans, International journal of antimicrobial agents, Legionella pneumophila, Llorens Lily, Macrolide, Macrolides/adverse effects/*therapeutic use, Male, Middle Aged, Mycoplasma, Mycoplasma pneumoniae, NEOMED College of Medicine, Phase III as Topic, Pneumonia, Randomized Controlled Trials as Topic, Talbot George H, Time Factors, Treatment Outcome

Outcome of treatment of respiratory tract infections due to Streptococcus pneumoniae, including drug-resistant strains, with pharmacokinetically enhanced amoxycillin/clavulanate.

The efficacy of a new pharmacokinetically enhanced formulation of amoxycillin/clavulanate (AMX/CA) 2000/125 mg, twice daily, designed to provide adequate levels of amoxycillin over the 12-h dosing interval to eradicate penicillin-resistant…

Tags: *Treatment Outcome, 2002, 80 and over, Adolescent, Adult, Aged, Amoxicillin-Potassium Clavulanate Combination/administration & dosage/*pharmacokinetics/pharmacology/*therapeutic use, Amoxicillin/adverse effects/therapeutic use, Bacterial, Bacterial/drug therapy/immunology, Bronchitis/drug therapy/microbiology, Combination/adverse effects/*therapeutic use, Department of Internal Medicine, Double-Blind Method, Drug Administration Schedule, Drug Resistance, Drug Therapy, Female, File Thomas M Jr, Follow-Up Studies, Humans, International journal of antimicrobial agents, Jacobs Michael R, Male, Microbial Sensitivity Tests, Middle Aged, Multicenter Studies as Topic, NEOMED College of Medicine, Pneumonia, Poole Michael D, Respiratory Tract Infections/*drug therapy/metabolism/microbiology, Streptococcal Infections/*drug therapy/metabolism/microbiology, Streptococcus pneumoniae/*drug effects, Wynne Brian

FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia.

OBJECTIVES: Ceftaroline, the active form of the prodrug ceftaroline fosamil, is a novel cephalosporin with bactericidal activity against important pathogens associated with community-acquired pneumonia (CAP), including Streptococcus pneumoniae and…

Tags: 2011, 80 and over, Aged, Bacteria, Bacteria/isolation & purification, Bacterial – Drug Therapy, Bacterial/*drug therapy, Ceftriaxone – Administration and Dosage, Ceftriaxone – Adverse Effects, Ceftriaxone/administration & dosage/adverse effects, Cephalosporins – Administration and Dosage, Cephalosporins – Adverse Effects, Cephalosporins/*administration & dosage/*adverse effects, Community-Acquired Infections – Drug Therapy, Community-Acquired Infections/*drug therapy, Critchley Ian A, Department of Internal Medicine, Double-Blind Method, Double-Blind Studies, Eckburg Paul B, Female, File Thomas M Jr, Friedland H David, Human, Humans, Infusions, Intravenous, Lee Jon, Llorens Lily, Low Donald E, Male, Middle Age, Middle Aged, NEOMED College of Medicine, Pneumonia, RANDOMIZED controlled trials, Talbot George H, The Journal of antimicrobial chemotherapy, Thye Dirk A, Treatment Outcome, Treatment Outcomes

Integrated analysis of FOCUS 1 and FOCUS 2: randomized, doubled-blinded, multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia.

BACKGROUND: Ceftaroline, the active form of ceftaroline fosamil, is a broad-spectrum cephalosporin with bactericidal activity against pathogens causing community-acquired pneumonia (CAP), including Streptococcus pneumoniae. Ceftaroline was evaluated…

Gemifloxacin once daily for 5 days versus 7 days for the treatment of community-acquired pneumonia: a randomized, multicentre, double-blind study.

OBJECTIVES: Short-course therapy has been advocated for the treatment of community-acquired pneumonia (CAP). We compared the efficacy and safety of 5 and 7 day courses of gemifloxacin for outpatient treatment of mild-moderate CAP. PATIENTS AND…

A disease model descriptive of progression between chronic obstructive pulmonary disease exacerbations and community-acquired pneumonia: roles for underlying lung disease and the pharmacokinetics/pharmacodynamics of the antibiotic.

Patients with chronic obstructive pulmonary disease (COPD) may progress to community-acquired pneumonia (CAP), but there has been no formal study of the factors responsible. We studied the influence of severity of underlying lung disease, pathogen…

Tags: *Anti-Bacterial Agents/pharmacokinetics/therapeutic use, *Community-Acquired Infections/drug therapy/microbiology/physiopathology/prevention & control, *Models, *Pneumonia, 2009, Adelman Martin H, Aged, Area Under Curve, Bacterial/drug therapy/microbiology/physiopathology/prevention & control, Biological, Bronchitis, Chronic Obstructive/drug therapy/microbiology/*physiopathology, Chronic/drug therapy/microbiology/physiopathology, Department of Internal Medicine, Disease Progression, Female, File Thomas M Jr, Humans, International journal of antimicrobial agents, Klugman Keith P, Lavin Bruce, Lung Diseases/complications/drug therapy/microbiology, Lung/microbiology, Male, Microbial Sensitivity Tests, Middle Aged, Monte Scott V, NEOMED College of Medicine, Paladino Joseph A, Pneumococcal/drug therapy/microbiology/physiopathology/prevention & control, Pneumonia, Pulmonary Disease, Schentag Jerome J, Severity of Illness Index, Singer Mendel E, Streptococcus pneumoniae/*drug effects, Yu Victor L

SOLITAIRE-IV: A Randomized, Double-Blind, Multicenter Study Comparing the Efficacy and Safety of Intravenous-to-Oral Solithromycin to Intravenous-to-Oral Moxifloxacin for Treatment of Community-Acquired Bacterial Pneumonia.

BACKGROUND: Solithromycin, a novel macrolide antibiotic with both intravenous and oral formulations dosed once daily, has completed 2 global phase 3 trials for treatment of community-acquired bacterial pneumonia. METHODS: A total of 863 adults with…

Tags: *clinical trial, *Community-acquired, *Pneumonia, *solithromycin, *Streptococcus pneumoniae, 2016, 80 and over, Administration, Adult, Aged, Anti-Bacterial Agents/*administration & dosage/adverse effects, Bacterial, Bacterial/diagnosis/*drug therapy/*microbiology, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Community-Acquired Infections/diagnosis/*drug therapy/*microbiology, Comorbidity, Das Anita F, Department of Internal Medicine, Drug Resistance, Female, Fernandes Prabhavathi, File Thomas M Jr, Fluoroquinolones/*administration & dosage/adverse effects, Gonong Joven Roque V, Humans, Intravenous, Jamieson Brian D, Keedy Kara, Macrolides/*administration & dosage/adverse effects, Male, Microbial Sensitivity Tests, Middle Aged, Moxifloxacin, NEOMED College of Medicine, Oldach David, Oral, Pneumonia, Rewerska Barbara, Sheets Amanda, Taylor David, Treatment Outcome, Triazoles/*administration & dosage/adverse effects, Vucinic-Mihailovic Violeta

Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.

BACKGROUND: Lefamulin, a pleuromutilin antibiotic, is active against pathogens commonly causing community-acquired bacterial pneumonia (CABP). The Lefamulin Evaluation Against Pneumonia (LEAP 1) study was a global noninferiority trial to evaluate…

Tags: 2019, Administration Intravenous, Adult, Aged, Anti-Bacterial Agents/administration & dosage/adverse effects/therapeutic use, antibiotic, Clinical Infectious Diseases, Das A, Diterpenes/administration & dosage/adverse effects/therapeutic use, Double-Blind Method, Female, File TM, Gasink LB, Gelone SP, Goldberg L, Hospital List, Humans, journalArticle, lefamulin, Linezolid/adverse effects/therapeutic use, Male, Microbial Sensitivity Tests, Middle Aged, Moxifloxacin, Moxifloxacin/administration & dosage/adverse effects/therapeutic use, Paukner S, pleuromutilin, Pneumonia, Pneumonia Bacterial/drug therapy/metabolism, Polycyclic Compounds/administration & dosage/adverse effects/therapeutic use, Randomized Controlled Trials as Topic, Saviski J, Seltzer E, Sweeney C, Talbot GH, Thioglycolates/administration & dosage/adverse effects/therapeutic use, Wicha WW

Safety and efficacy of cangrelor, an intravenous, short-acting platelet inhibitor in patients requiring coronary artery bypass surgery.

OBJECTIVE: Oral P2Y(1)(2) platelet receptor inhibitors are a cornerstone of reducing complications in patients with acute coronary syndromes or coronary stents. Guidelines advocate discontinuing treatment with P2Y(1)(2) platelet receptor inhibitors…

Tags: 2013, 80 and over, Adenosine Monophosphate/administration & dosage/*analogs & derivatives, Administration, Adult, Aged, Angiolillo Dominick J, Blood Transfusion/*statistics & numerical data, Brtko Miroslav, Cannon Louis A, Chandna Harish, Chronos Nicholas, Combination/statistics & numerical data, Coronary Artery Bypass/*statistics & numerical data, Dietrich Markus, Drug Therapy, Drug-Related Side Effects and Adverse Reactions/epidemiology, Dyke Cornelius M, Female, Firstenberg Michael S, Holmes David R, Humans, Hutyra Martin, Injections, Intravenous, Liu Tiepu, Male, Manoukian Steven V, Middle Aged, Montalescot Gilles, Oral, Placebo Effect, Platelet Aggregation Inhibitors/administration & dosage, Postoperative Hemorrhage/*epidemiology/*prevention & control, Prats Jayne, Premedication/*statistics & numerical data, Prevalence, Price Matthew, Purinergic P2Y Receptor Antagonists/administration & dosage, Pyridines/*administration & dosage, Ramaiahm Chandrashekar, Risk Assessment, The heart surgery forum, Todd Meredith, Topo Eric J, Treatment Outcome, Tummala Pradyumna, United States/epidemiology, Voeltz Michele, Welsby Ian

The assessment and treatment of back and neck pain: an initial investigation in a primary care practice-based research network.

AIM: The purpose of this study was to conduct an exploratory examination of the current state of non-malignant acute and chronic back and neck pain assessment and management among primary care providers in a multi-site, practice-based research…

Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011.

IMPORTANCE: The National Action Plan for Combating Antibiotic-Resistant Bacteria set a goal of reducing inappropriate outpatient antibiotic use by 50% by 2020, but the extent of inappropriate outpatient antibiotic use is unknown. OBJECTIVE: To…

Tags: 2016, Adolescence, Adolescent, Adult, Aged, Ambulatory Care – Statistics and Numerical Data, Ambulatory Care/*statistics & numerical data, Anti-Bacterial Agents/*therapeutic use, Antibiotics – Therapeutic Use, Bartoces Monina, Child, Department of Internal Medicine, Enns Eva A, Female, File Thomas M Jr, Finkelstein Jonathan A, Fleming-Dutra Katherine E, Gerber Jeffrey S, Health Care Surveys, Hersh Adam L, Hicks Lauri A, Human, Humans, Hyun David Y, Inappropriate Prescribing – Statistics and Numerical Data, Inappropriate Prescribing/*statistics & numerical data, Infant, JAMA, Linder Jeffrey A, Lynfield Ruth, Male, Margolis David J, May Larissa S, Merenstein Daniel, Metlay Joshua P, Middle Age, Middle Aged, NEOMED College of Medicine, Newborn, Newland Jason G, Otitis Media, Otitis Media – Drug Therapy, Pharyngitis – Drug Therapy, Pharyngitis/drug therapy, Physicians'/*statistics & numerical data, Piccirillo Jay F, Practice Patterns, Preschool, Prevalence, Respiratory Tract Infections – Drug Therapy, Respiratory Tract Infections/drug therapy, Roberts Rebecca M, Sanchez Guillermo V, Shapiro Daniel J, Suda Katie J, Suppurative/*drug therapy, Surveys, Thomas Ann, United States, Woo Teri Moser, Zetts Rachel M

Racial differences in performance-based function and potential explanatory factors among individuals with knee osteoarthritis.

Objective: In individuals with knee osteoarthritis (OA), self-reported physical function is poorer in African Americans than in whites, but whether this difference holds true for objective assessments is unclear. The purpose of this study was to…

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