Browse Items (61 total)
- Tags: Geldenhuys Werner J
Identification of small molecules that bind to the mitochondrial protein mitoNEET.
Tags: *Bioenergetics, *Glitazones, *Mitochondria, *Small Molecule Libraries, *Type II diabetes, 2016, Bioorganic & medicinal chemistry letters, Darvesh Altaf S, Department of Pharmaceutical Sciences, Geldenhuys Werner J, Hypoglycemic Agents/chemistry/metabolism, Leeper Thomas C, Ligands, Mitochondrial Proteins/*metabolism, Morris Daniel L, NEOMED College of Pharmacy, Protein Binding, Sullivan Patrick G, Thiazolidinediones/chemistry/metabolism, Yonutas Heather M
The emergence of designed multiple ligands for neurodegenerative disorders.
Tags: *Drug Design, *Ligands, 2011, Amyloid beta-Peptides/metabolism, Antiparkinson Agents/therapeutic use, Carroll Richard T, Clinical Trials as Topic, Geldenhuys Werner J, Humans, Molecular Structure, Neurodegenerative Diseases/*drug therapy, Neuroprotective Agents/*therapeutic use, Progress in neurobiology, Van der Schyf Cornelis J, Youdim Moussa B H
Development and validation of an LC-MS/MS method for determination of the L-type voltage-gated calcium channel/NMDA receptor antagonist NGP1-01 in mouse serum.
Tags: 2014, Anderson David J, Animals, Bridged-Ring Compounds/*blood, Calcium Channel Blockers/*blood, Chromatography, Crish Samuel D, Department of Pharmaceutical Sciences, Geldenhuys Werner J, Gobburi Ashta Lakshmi Prasad, Jogiraju Harini, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, LC-MS/MS, Limit of Detection, Liquid/*methods, Mice, Mouse serum, Multifunctional drug, N-Methyl-D-Aspartate/*antagonists & inhibitors, NEOMED College of Pharmacy, Neuroprotective agent, NGP1-01, Pedada Kiran K, Pentacycloundecylamine, Receptors, Reproducibility of Results, Tandem Mass Spectrometry/*methods, Van der Schyf Cornelis J, Zhou Xiang
Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization.
Tags: *Cell Movement, 2012, AbouAlaiwi Wissam A, Actin Cytoskeleton/*metabolism, Adapala Ravi K, Animals, Blotting, Bursley Chris, Capillary Permeability/*physiology, Cell Adhesion, Cilia/metabolism, Department of Integrative Medical Sciences, Endothelial Cells/cytology/*metabolism, Fluorescent Antibody Technique, Focal Adhesions/metabolism, Geldenhuys Werner J, HSP27 Heat-Shock Proteins/*metabolism, Jones Thomas J, Journal of cellular physiology, Mice, Nauli Surya M, NEOMED College of Medicine, Polycystic Kidney Diseases/physiopathology, Signal Transduction/physiology, Thodeti Charles K, Transgenic, Western
Generation and characterization of ATP analog-specific protein kinase Cdelta.
Tags: 2015, Adenosine Triphosphate/*analogs & derivatives/*chemistry, Amino Acid, Amino Acid Sequence, Animals, ATP, Catalysis, Cercopithecus aethiops, Chemical Biology, Chou Wen-Hai, COS Cells, Geldenhuys Werner J, Glutamine/chemistry, Han Xiqian, Humans, Inbred C57BL, Kumar Varun, Leucine/chemistry, Lysine/chemistry, Messing Robert O, Mice, Molecular Sequence Data, Neutrophils/metabolism, Phenylalanine/chemistry, Phosphorylation, Protein Binding, Protein Kinase C (PKC), Protein Kinase C-delta/*metabolism, Protein Phosphorylation, Purines/chemistry, Sequence Homology, Signal Transduction, stroke, Substrate Specificity, Superoxides/chemistry, The Journal of biological chemistry, Transgenic, Wang Dan, Weng Yi-Chinn
Novel thiazolidinedione mitoNEET ligand-1 acutely improves cardiac stem cell survival under oxidative stress.
Tags: 2015, Animals, Basic research in cardiology, Cardiac/cytology/*drug effects, Carroll Richard T, Cell Differentiation/drug effects, Chilian William M, Department of Integrative Medical Sciences, Enrick Molly K, Flow Cytometry, Geldenhuys Werner J, Knockout, Kolz Christopher L, Logan Suzanna J, Male, Mice, Mitochondrial Membranes/metabolism, Mitochondrial Proteins/metabolism, Myocytes, NEOMED College of Medicine, Ohanyan Vahagn A, Oxidative Stress/drug effects/*physiology, Rats, Real-Time Polymerase Chain Reaction, Stem Cells/cytology/*drug effects, Stevanov Kelly M, Thiazolidinediones/*pharmacology, Yin Liya, Zucker
Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis.
Tags: 2012, Animals, Anticarcinogenic Agents/pharmacology/*therapeutic use, Awale Prabha, Bhatia Deepak, Bishayee Anupam, Carroll Richard T, Current pharmaceutical biotechnology, Cytokines/genetics/*metabolism, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diethylnitrosamine, Experimental/chemically induced/metabolism/*prevention & control, Female, Geldenhuys Werner J, Gene Expression Regulation/drug effects, Liver Neoplasms, Liver/drug effects/metabolism, Mbimba Thomas, Messenger/metabolism, NEOMED College of Pharmacy, Phenobarbital, Rats, Resveratrol, RNA, Sprague-Dawley, Stilbenes/pharmacology/*therapeutic use
Engineering triiodothyronine (T3) nanoparticle for use in ischemic brain stroke.
Tags: 2013, Blood-brain barrier, Brain stroke, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Drug delivery and translational research, Geldenhuys Werner J, Mdzinarishvili Alexander, Nanoparticles, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Neuroprotection, Sadana Prabodh, Sutariya Vijaykumar, Talasila Phani K, Thyroid hormone
Novel compounds that target lipoprotein lipase and mediate growth arrest in acute lymphoblastic leukemia.
Tags: *Acute lymphoblastic leukemia, *Cancer, *Co-culture model, *Lipids, *Lipoprotein lipase, *Metabolism, 2018, Amides/chemistry/metabolism/pharmacology, Antineoplastic Agents/*chemistry/metabolism/pharmacology, Binding Sites, Bioorganic & medicinal chemistry letters, Cell Line, Cell Proliferation/drug effects, Coculture Techniques, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dyslipidemias/complications/metabolism/pathology, Geldenhuys Werner J, Gibson Laura F, Humans, Lipoprotein Lipase/antagonists & inhibitors/*metabolism, Mesenchymal Stem Cells/cytology/metabolism, Molecular Docking Simulation, Nair Rajesh R, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Piktel Debbie, Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications/metabolism/pathology, Protein Binding, Protein Structure, Sadana Prabodh, Serum Albumin/chemistry/metabolism, Tertiary, Tumor
Screening and identification of novel compounds with potential anti-proliferative effects on gallium-resistant lung cancer through an AXL kinase pathway.
Tags: 2014, Alazizi Adnan, Antineoplastic Agents/chemical synthesis/chemistry/*pharmacology, Antitumor, AXL, Bioorganic & medicinal chemistry letters, Cell Line, Cell Proliferation/drug effects, Cell Survival/drug effects, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Drug Resistance, Drug Screening Assays, Gallium, Gallium-resistance, Gallium/pharmacology, Geldenhuys Werner J, Humans, Lin Li, Liva Sophia, Lung cancer, Lung Neoplasms/drug therapy/*enzymology/*pathology, Molecular Structure, Naphthalenes/chemistry/*pharmacology, NEOMED College of Pharmacy, Neoplasm/drug effects, Oyewumi Moses O, Proto-Oncogene Proteins/*antagonists & inhibitors/metabolism, Pyrazoles/chemistry/*pharmacology, Quinolines/chemistry/*pharmacology, Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors/metabolism, Structure-Activity Relationship, Tetrazoles/chemistry/*pharmacology, Tumor, Virtual screening
A quantitative LC-MS/MS method for determination of thiazolidinedione mitoNEET ligand NL-1 in mouse serum suitable for pharmacokinetic studies.
Tags: %CV, %RE, 1-Methyl-4-phenyl-1, 2, 2014, 3, 3-thiazolidine-2, 4-dione, 5-[3, 5-[4-hydroxy-3, 5-di-tert-butyl-4-hydroxyphenyl)methyl]-1, 5-dimethyl-phenyl)methyl]thiazolidine-2, 6-tetrahydropyridine, Anderson David J, Animals, Carroll Richard T, Carry-over, Chromatography, Department of Internal Medicine, Geldenhuys Werner J, High Pressure Liquid/*methods, internal standard, IS, Jogiraju Harini, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, LC-MS/MS, Limit of Detection, Lin Li, LLOQ, lower limit of quantification, Methanol, Mice, mitoNEET, Mouse serum, MPTP, MRM, multiple reaction monitoring, NEOMED College of Medicine, NL-1, NL-2, Pedada Kiran K, percent coefficient of variation, peroxisome proliferator activated receptor-gamma, pharmacokinetic, PK, PPAR-gamma, QC, Quality Control, relative error, relative matrix effect, RME, SD, standard deviation, Tandem Mass Spectrometry/*methods, thiazolidinedione, Thiazolidinedione (TZD), Thiazolidinediones/*blood, TZD, Zhou Xiang
Osteoactivin inhibition of osteoclastogenesis is mediated through CD44-ERK signaling.
Tags: *MAP Kinase Signaling System, *Signal Transduction, 2016, Abdelmagid Samir M, Animals, Cell Differentiation, Cells, Cultured, Department of Anatomy & Neurobiology, Experimental & molecular medicine, Eye Proteins/*metabolism, Geldenhuys Werner J, Hyaluronan Receptors/*metabolism, Inbred C57BL, Jaber Fatima A, Male, Mbimba Thomas S, Membrane Glycoproteins/*metabolism, Mice, Moussa Fouad M, NEOMED College of Medicine, Novak Kimberly, Osteoclasts/*cytology/metabolism, RANK Ligand/metabolism, Recombinant Proteins/metabolism, Safadi Fayez F, Sondag Gregory R, Yu Bing
Development and validation of a novel RP-HPLC method for the analysis of reduced glutathione.
Tags: 2012, Chromatography, Geldenhuys Werner J, Glutathione/*analysis, High Pressure Liquid/*methods, Journal of chromatographic science, Limit of Detection, Linear Models, Nanoparticles/chemistry, Pharmaceutical Preparations/chemistry, Reproducibility of Results, Reverse-Phase/*methods, Spectrophotometry, Sutariya Vijaykumar, Ultraviolet, Wehrung Daniel
Multimodal drugs and their future for Alzheimer's and Parkinson's disease.
Tags: 2011, Alzheimer Disease/*drug therapy/*enzymology/prevention & control, Animals, Combined Modality Therapy/*methods, Forecasting, Geldenhuys Werner J, Humans, International review of neurobiology, Monoamine Oxidase Inhibitors/*pharmacology/therapeutic use, Parkinson Disease/*drug therapy/*enzymology/prevention & control, Van der Schyf Cornelis J
Polycyclic compounds: ideal drug scaffolds for the design of multiple mechanism drugs?
Tags: *Drug Design, 2009, Adamantane/chemistry/pharmacology, Animals, Central Nervous System Diseases/*drug therapy, Geldenhuys Werner J, Humans, Molecular Structure, Neuroprotective Agents/chemistry/*pharmacology/therapeutic use, Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, Polycyclic Compounds/*chemistry/pharmacology/therapeutic use, Psychotropic Drugs/chemistry/*pharmacology/therapeutic use, Quantitative Structure-Activity Relationship, Van der Schyf Cornelis J
Novel multifunctional anti-Alzheimer drugs with various CNS neurotransmitter targets and neuroprotective moieties.
Tags: 2007, Alzheimer Disease/pathology/*prevention & control, Amit Tamar, Animals, Avramovich Yael, Bar Am Orit, Biological, Central Nervous System/chemistry/*drug effects/metabolism, Current Alzheimer research, Drug Design, Fridkin Mati, Gal Shunit, Geldenhuys Werner J, Humans, Mandel Silvia, Models, Neuroprotective Agents/*chemistry/pharmacology/*therapeutic use, Neurotransmitter Agents/chemistry/*metabolism, Sagi Yotam, Van der Schyf Cornelis J, Weinreb Orly, Youdim Moussa B H, Zheng Hailin
Identification of Novel Agents for the Treatment of Brain Metastases of Breast Cancer.
Tags: 2017, ADME, Animals, Antineoplastic Agents/*therapeutic use, Apoptosis, Brain cancer, Brain Neoplasms/*drug therapy/pathology/*secondary, Breast Neoplasms/*pathology, Cell Line, Chemotherapy, CNS, Current cancer drug targets, Department of Anatomy & Neurobiology, distribution, Drug Discovery, Drug Resistance, Female, Geldenhuys Werner J, Griffith Jessica I G, Humans, Lockman Paul R, Mice, NEOMED College of Medicine, Safadi Fayez F, Sondag Gregory R, Terell-Hall Tori B, Tumor, Venishetty Vinay K
Antitumor efficacy and tolerability of systemically administered gallium acetylacetonate-loaded gelucire-stabilized nanoparticles.
Tags: *Lethal Dose 50, 2013, Adenocarcinoma/*drug therapy/pathology, Animals, Antineoplastic Agents/administration & dosage/pharmacokinetics/toxicity, Bi Lipeng, Cell Line, Department of Pharmaceutical Sciences, Dose-Response Relationship, Drug, Drug Stability, Drug Tolerance, Gallium/*administration & dosage/pharmacokinetics/*toxicity, Geldenhuys Werner J, Humans, Journal of biomedical nanotechnology, Metabolic Clearance Rate, Mice, Nanocapsules/*administration & dosage/chemistry/*toxicity, NEOMED College of Pharmacy, Nude, Organ Specificity, Oyewumi Moses O, Tissue Distribution, Treatment Outcome, Triglycerides/chemistry, Tumor, Wehrung Daniel
Biocompatibility, efficacy and biodistribution of Gelucire-stabilized nanoparticles engineered for docetaxel delivery.
Tags: *Biocompatible Materials, *Nanoparticles, 2012, Animals, Antineoplastic Agents/*administration & dosage/pharmacokinetics/pharmacology, Bi Lipeng, Department of Pharmaceutical Sciences, Docetaxel, Geldenhuys Werner J, Journal of nanoscience and nanotechnology, Macrophage Activation/drug effects, NEOMED College of Pharmacy, Oyewumi Moses O, Platelet Aggregation/drug effects, Rats, Reactive Oxygen Species/metabolism, Taxoids/*administration & dosage/pharmacokinetics/pharmacology, Tissue Distribution, Wehrung Daniel
Effects of gelucire content on stability, macrophage interaction and blood circulation of nanoparticles engineered from nanoemulsions.
Tags: 2012, Animals, ATP Binding Cassette Transporter, Calorimetry, Colloids and surfaces. B, Biointerfaces, Department of Pharmaceutical Sciences, Differential Scanning, Drug Carriers/*chemical synthesis/pharmacokinetics, Drug Stability, Emulsions/chemistry, Fatty Alcohols/*chemistry, Fourier Transform Infrared, Geldenhuys Werner J, Humans, Inbred BALB C, Macrophages/*drug effects/metabolism, Member 1/metabolism, Mice, Nanoparticles/*chemistry/ultrastructure, NEOMED College of Pharmacy, Oils/chemistry, Oyewumi Moses O, Paclitaxel/pharmacokinetics, Particle Size, Polyethylene Glycols/*chemistry, Reactive Oxygen Species/metabolism, Rhodamine 123/metabolism, Spectroscopy, Subfamily B, Water/chemistry, Wehrung Daniel
Synthesis and Biological Evaluation of Pentacycloundecylamines and Triquinylamines as Voltage-Gated Calcium Channel Blockers.
Tags: 2016, Alicyclic/chemical synthesis/*chemistry/pharmacology, Amines/chemical synthesis/*chemistry/pharmacology, Animals, Apoptosis/drug effects, Archiv der Pharmazie, Calcium Channel Blockers/chemical synthesis/*chemistry/pharmacology, Calcium Channels, Calcium/*metabolism, Cell Survival/drug effects, Domingo Olwen C, Geldenhuys Werner J, Hydrocarbons, Hydrogen Peroxide/pharmacology, L-Lactate Dehydrogenase/metabolism, L-type calcium channel (LTCC) blockers, L-Type/*metabolism, Malan Sarel F, Multifunctional drugs, Neurodegeneration, PC12 Cells, Pentacycloundecylamine, Quinones/chemical synthesis/*chemistry/pharmacology, Rats, Structure-Activity Relationship, Triquinylamine, Van der Schyf Cornelis J, Young Lois-May