Browse Items · NEOMED Bibliography Database

A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene.

BACKGROUND & AIMS: Inhibition of cholesterol 7alpha-hydroxylase (CYP7A1) by bile acids and inflammatory cytokines provides an important mechanism to protect hepatocytes from bile acid toxicity during cholestasis. Transforming growth factor beta1…

Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC), one of the most lethal cancers, results in more than one million fatalities worldwide every year. In view of the limited therapeutic alternatives and poor prognosis of liver cancer, preventive control approaches,…

Tags: *Chemoprevention, 2011, Analysis of Variance, Animal, Animal Studies, Animal/drug effects, Animals, Antioxidants, Behavior, Bishayee Anupam, Blotting, Booth Tristan D, Carcinoma, Cardiotoxicity, Cardiotoxins/*toxicity, Chemoprevention, Data Analysis Software, Department of Integrative Medical Sciences, Descriptive Statistics, Disease Models, Doppler, Dose-Response Relationship, Drug, Echocardiography, Feeding Behavior/drug effects, Female, Fisher's Exact Test, Funding Source, Heart – Drug Effects, Heart/drug effects/physiopathology, Hepatocellular – Prevention and Control, Hepatocellular/*drug therapy/pathology/physiopathology, Hepatocytes/drug effects/pathology, Hodnichak Cheryl M, Humans, Investigational new drugs, Liver Neoplasms/*drug therapy/pathology/physiopathology, Liver/drug effects/pathology/physiopathology, Luther Daniel J, Meszaros J Gary, NEOMED College of Medicine, Ohanyan Vahagn, Polyphenols – Therapeutic Use, Rats, Resveratrol, Shamhart Patricia E, Sisakian Hamayak, Sprague-Dawley, Stilbenes/*therapeutic use, Systole/drug effects, Western

The utility of routine frozen section examination for intraoperative diagnosis of thyroid cancer

BACKGROUND: The value of routine frozen section examination for intraoperative diagnosis of thyroid cancer and determination of extent of thyroidectomy is controversial and needs to be evaluated on an institution to institution basis. METHODS: A…

Tags: 1996, American journal of surgery, Biopsy, Carcinoma, Journal Article or Conference Abstract Publication, Management, Marty J J, McHenry C R, nodules, Raeburn C, Strickland T, Surgery

Metastatic colorectal carcinoma: an unusual presentation.

Cutaneous metastases from colorectal carcinomas occur infrequently, usually in the setting of disseminated disease. They most commonly appear on the abdominal wall or perineal area; metastases to other locations of the skin are rare. We describe a…

Tags: 2009, Aged, Carcinoma, Colorectal Neoplasms/*pathology, Diagnosis, Differential, Fatteh Shokat, Humans, Journal of cutaneous pathology, Lip Neoplasms/*secondary, Lymphatic Metastasis/pathology, Male, Moonda Afreen, Signet Ring Cell/*secondary, Skin Neoplasms/*secondary, Sweat Gland Neoplasms/pathology

Practice Gaps. Skin cancer detection in hair salons: opportunity knocking: comment on "Skin cancer knowledge, attitudes, and behaviors in the salon".

Tags: *Barbering, *Health Knowledge, 2011, Archives of dermatology, Attitudes, Basal Cell/*psychology, Carcinoma, Female, Humans, Male, Melanoma/*psychology, Mostow Eliot N, Practice, Skin Neoplasms/*psychology, Squamous Cell/*psychology

Glycogen-rich malignant melanomas and glycogen-rich balloon cell malignant melanomas - Frequency and pattern of PAS positivity in primary and metastatic melanomas

Objective.-After identifying a metastatic glycogen-rich balloon cell malignant melanoma, originally thought to be a benign clear cell tumor of the lung, we investigated the extent of positive reactions, or "positivity," of malignant melanoma to…

Tags: 1998, Archives of pathology & laboratory medicine, Campbell T E, Carcinoma, Fatteh S M, Journal Article, Lung, Medical Laboratory Technology, Nowak M A, Pathology, Research & Experimental Medicine, soft parts, sugar tumor

Osteoactivin (GPNMB) ectodomain protein promotes growth and invasive behavior of human lung cancer cells.

The potential application of GPNMB/OA as a therapeutic target for lung cancer will require a greater understanding of the impact of GPNMB/OA ectodomain (ECD) protein shedding into tumor tissues. Thus, in this work we characterized GPNMB/OA expression…

Tonsillar metastasis of signet-ring cell adenocarcinoma of the colon.

Cases of primary colorectal signet-ring cell carcinoma metastatic to the tonsil are extremely rare. To the best of our knowledge, only 4 such cases have been previously reported in the literature. We report a new case in a 76-year-old white woman.…

Tags: 2010, Aged, Biopsy, Carcinoma, Colonic Neoplasms/*pathology, Ear, nose, & throat journal, Female, Head and Neck Neoplasms/drug therapy/pathology/radiotherapy/*secondary, Humans, Needle, Park Kelly K, Park Youn W, Signet Ring Cell/drug therapy/pathology/radiotherapy/*secondary, Terminal Care, Tonsillar Neoplasms/drug therapy/pathology/radiotherapy/*secondary

Parotid gland metastasis from renal cell carcinoma.

Tags: 2002, 80 and over, Aged, Biopsy, Carcinoma, Descriptive Statistics, Diagnosis, Differential, Female, Hlivko T J, Human, Kidney Neoplasms – Pathology, Laryngoscope, Literature Review, Needle, Park Y W, Parotid Neoplasms

Diagnosis at a glance.

Tags: 2003, Basal Cell – Diagnosis, Carcinoma, Emergency Medicine (00136654), Hemangioma – Diagnosis, Male, Matthews M, Middle Age, Mouth Neoplasms – Diagnosis, Park Y W, Wu YT

Diagnosis at a glance.

Tags: 2003, Carcinoma, Child, Cysts – Diagnosis – In Infancy and Childhood, Emergency Medicine (00136654), Male, Middle Age, Park Y W, Squamous Cell – Diagnosis, Tang T, Tongue Diseases – Diagnosis, Wu YT

Parotid gland metastasis from renal cell carcinoma.

OBJECTIVE: To discuss the diagnosis and management of metastatic renal cell carcinoma presenting as a parotid mass by studying such cases. STUDY DESIGN: Retrospective review. METHODS: Identification of 24 previously reported cases of renal cell…

Tags: 2002, 80 and over, Aged, Biopsy, Carcinoma, Diagnosis, Differential, Female, Hlivko Thomas J, Humans, Kidney Neoplasms/*pathology, Needle, Park Youn W, Parotid Neoplasms/pathology/*secondary, Renal Cell/pathology/*secondary, Retrospective Studies, The Laryngoscope

Squamous cell carcinoma arising from chronic osteomyelitis of the patella.

Prostate cancer and other xenografts from cells in peripheral blood of patients

Good models for the investigation of human prostate cancer are few. Cells from approximately 9.2-21 ml of peripheral blood from patients with metastatic prostate cancer or metastatic colon cancer were injected s.c. into nude mice. Prostate cancer…

Contrast-enhanced ultrasound detection and treatment guidance in a renal transplant patient with renal cell carcinoma.

Contrast-enhanced ultrasonography (CEUS) is an imaging modality that shows promise in the detection and characterization of renal masses, as well as treatment through CEUS-guided percutaneous radiofrequency ablation. These techniques may be…

CLEAR-CELL ADENOCARCINOMA ARISING FROM A URETHRAL DIVERTICULUM

Carcinoma of the urethra is rare with only about 1,500 cases in the literature. Even more rare is carcinoma arising from a urethral diverticulum with about 100 cases reported to date. We report a case of clear cell adenocarcinoma arising from a…

Tags: 1995, Adenocarcinoma, Carcinoma, diverticulum, Journal Article, Journal of Urology, Rich R R, Seballos R M, urethra, Urology & Nephrology

Acquired inhibitor to factor VIII in small cell lung cancer: a case report and review of the literature.

Acquired hemophilia (antibodies or inhibitors to factor VIII) is the most common acquired disease affecting clotting factors. It has been described in association with autoimmune disease, malignancy, dermatologic disorders, in the postpartum period,…

Tags: 2001, Ahmed F, Annals of hematology, Carcinoma, Crock R, Department of Internal Medicine, Factor VIII/*antagonists & inhibitors, Humans, Lara L, Lung Neoplasms/*chemistry, Male, Middle Aged, NEOMED College of Medicine, Rutecki G W, Shwaiki A, Small Cell/*chemistry, Whittier F C

Relationship between breast cancer and meningioma.

Several authors have suggested the existence of a relationship between breast cancer and meningioma occurring in the same patient. I describe four patients who had both of these neoplasms and present findings that dispute the implied relationship…

Tags: 1992, Aged, Breast Neoplasms/*diagnosis, Carcinoma, Female, Humans, Intraductal, Meningeal Neoplasms/*diagnosis, Meningioma/*diagnosis, Middle Aged, Neoplasms, Noninfiltrating/*diagnosis, Ovarian Neoplasms/diagnosis, Second Primary/*diagnosis, Smith-Behn J, Southern medical journal, Time Factors

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression.

UNLABELLED: Mouse fibroblast growth factor 15 (FGF15) and human ortholog FGF19 have been identified as the bile acid-induced intestinal factors that mediate bile acid feedback inhibition of cholesterol 7alpha-hydroxylase gene (C YP7A1) transcription…

Tags: 2009, Butadienes/pharmacology, Carcinoma, Cell Line, Chenodeoxycholic Acid/*pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*biosynthesis, Cytoplasmic and Nuclear/metabolism/physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, Fibroblast Growth Factor, Fibroblast Growth Factors/drug effects/*physiology, Gene Expression/drug effects, Hepatocellular/metabolism, Hepatocytes/metabolism, Hepatology (Baltimore, Md.), Humans, Isoxazoles/pharmacology, Li Tiangang, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3/metabolism, NEOMED College of Medicine, Nitriles/pharmacology, Owsley Erika, Receptor, Receptors, Signal Transduction/drug effects, Song Kwang-Hoon, Strom Stephen, Transcription Factors/metabolism, Tumor, Type 4/antagonists & inhibitors

Canertinib induces ototoxicity in three preclinical models.

Neuregulin-1 (NRG1) ligand and its epidermal growth factor receptor (EGFR)/ERBB family regulate normal cellular proliferation and differentiation in many tissues including the cochlea. Aberrant NRG1 and ERBB signaling cause significant hearing…

Development of bilateral lower extremity Marjolin ulcers after childhood burns.

Tags: 2008, American journal of orthopedics (Belle Mead, N.J.), Burns/*complications, Carcinoma, Humans, Male, Middle Aged, Scharschmidt Tom, Skin Neoplasms/*etiology/surgery, Skin Ulcer/*etiology/surgery, Squamous Cell/*etiology/surgery, Tank Jason, Time Factors, Weiner Scott D

Small cell carcinoma of the ovary.

A case of a 29-year-old woman with primary small cell carcinoma of the ovary associated with hypercalcemia is presented. Despite intensive surgical and chemotherapeutic intervention, the patient expired after 19 months. Literature review indicates…

Tags: 1991, Adult, Antineoplastic Agents/therapeutic use, Bone Marrow Transplantation, Breast Neoplasms/secondary, Carcinoma, Cloney D J, Combined Modality Therapy, Female, Gynecologic oncology, Humans, Hypercalcemia/complications, Knight C A, Lung Neoplasms/secondary, Ovarian Neoplasms/*pathology, Rosman P M, Small Cell/*pathology/secondary/surgery, Taraszewski R

Black currant anthocyanins abrogate oxidative stress through Nrf2- mediated antioxidant mechanisms in a rat model of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC), considered to be one of the most lethal cancers with almost \textgreater 1 million deaths reported annually worldwide, remains a devastating disease with no known effective cure. Hence, chemopreventive strategies come…

Tags: *Phytotherapy, 2012, Alkylating Agents/toxicity, Animals, Anthocyanins/*therapeutic use, Antioxidants/therapeutic use, Barnes Kendra F, Bhatia Deepak, Bishayee Anupam, Blotting, Carcinoma, Current cancer drug targets, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diet, Diethylnitrosamine/toxicity, Experimental/chemically induced/metabolism/*prevention & control, Glutathione Transferase, Haznagy-Radnai Erzsebet, Hepatocellular/chemically induced/metabolism/*prevention & control, Hohmann Judit, Immunoenzyme Techniques, Lipid Peroxidation/drug effects, Liver Neoplasms, Male, Messenger/genetics, NEOMED College of Pharmacy, NF-E2-Related Factor 2/genetics/*metabolism, Nitric Oxide Synthase Type II/genetics/metabolism, Oxidative Stress/*drug effects, Rats, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Ribes/*chemistry, RNA, Signal Transduction, Sprague-Dawley, Thoppil Roslin J, Tyrosine/analogs & derivatives/metabolism, Western

TRPV4 channels regulate tumor angiogenesis via modulation of Rho/Rho kinase pathway.

Targeting angiogenesis is considered a promising therapy for cancer. Besides curtailing soluble factor mediated tumor angiogenesis, understanding the unexplored regulation of angiogenesis by mechanical cues may lead to the identification of novel…

Antitumor activities of extracts from selected desert plants against HepG2 human hepatocellular carcinoma cells.

CONTEXT: Phytochemicals are produced by desert plants to protect themselves against stressful environments. They have been shown to be useful in preventing and fighting adverse pathophysiological conditions and complex diseases, including cancer.…

A Simple and Effective Treatment for Ectopic Sebaceous Glands on the Areola

The authors have indicated no significant interest with commercial supporters.

Tags: 2010, bichloracetic acid, Brodell R T, Carcinoma, dermatologic surgery, Dermatology, fordyce spots, granules, Journal Article, mucosa, Surgery, therapy, Tulbert B

Spreading pigmented actinic keratosis: a review.

INTRODUCTION: Spreading pigmented actinic keratosis (SPAK) is a common, but uncommonly reported or appreciated, variant of classic actinic keratosis (AK). It can mimic different pigmented lesions, which may be benign (eg, solar lentigo) or malignant…

Association of Thyroid, Breast and Renal Cell Cancer: A Population-based Study of the Prevalence of Second Malignancies

Analysis of the National Cancer Institute's Surveillance, Epidemiology, and End Results data has shown that the incidence of thyroid cancer is higher in patients with a preexisting malignancy and that the incidence of other malignancies is higher in…

Tags: 2013, Age, Annals of surgical oncology, Carcinoma, Eaton J L, Journal Article, McHenry C R, multiple primary breast, oncology, primary tumors, Risk, Surgery, united-states, Van Fossen V L, Wilhelm S M, Women

Pilomatricoma of the upper arm in an orthopaedic clinic.

Correlation of menstrual cycle at time of breast cancer surgery to disease-free and overall survival

The timing of surgery during the menstrual cycle of premenopausal breast cancer patients was correlated with their disease-free survival (DFS) and overall survival (OS). The study included 150 premenopausal patients treated for breast cancer between…

Tags: 1997, Bourguet C C, Carcinoma, General & Internal Medicine, Journal Article, Kadivar T F, killer cell-activity, Mastectomy, operation, phase, premenopausal women, Prognosis, Receptor, Southern medical journal, stage, status, surgical cure, Vanek V W

Clinical disease course during the last year in ovarian cancer

Objective(s). The objective was to determine whether there were changes in the pattern and nature of hospitalizations during the last year that could be used in the assessment of whether chemotherapy should be continued. Methods. Retrospective data…

Surgical treatments for vulvar and vaginal dysplasia - A randomized controlled trial

OBJECTIVE: To compare pain, adverse effects and recurrence of dysplasia in patients with vaginal intraepithelial neoplasia or vulvar intraepithelial neoplasia prospectively treated by carbon dioxide laser or ultrasonic surgical aspiration. METHODS:…

Tags: 2007, Aspiration, carbon-dioxide laser, Carcinoma, excision, Gibbins K, Gibbons H E, Hopkins M P, imiquimod cream, intraepithelial neoplasia-iii, Jenison E L, Journal Article, Management, Obstetrics & Gynecology, Obstetrics and gynecology, therapy, vaginectomy, vaporization, von Gruenigen V E

Alternative medicine in gynecologic oncology: A case report.

A patient with Stage IIB squamous cell cancer of the cervix presented 10 days into her primary radiation therapy with neutropenic fever and diarrhea requiring hospitalization and delay in treatment. The patient's history revealed extensive use of…

Tags: *Complementary Therapies, 2000, Carcinoma, Diarrhea/*etiology, Female, Fever/*etiology, Gynecologic oncology, Hopkins M P, Hospitalization, Humans, Medical History Taking, Medicinal/*adverse effects, Middle Aged, Neutropenia/*etiology, Plants, Squamous Cell/drug therapy/*radiotherapy, Time Factors, Uterine Cervical Neoplasms/drug therapy/*radiotherapy, von Gruenigen V E

Assessment of Factors That Contribute to Decreased Quality of Life in Gynecologic Oncology Group Ovarian Cancer Trials

BACKGROUND: The objective of this study was to assess which quality-of-life (QOL) line items on the Functional Assessment of Cancer Therapy-Ovarian (FACT-O) were associated with low QOL in women who were receiving chemotherapy for ovarian cancer.…

A Comparison of Quality-of-Life Domains and Clinical Factors in Ovarian Cancer Patients: A Gynecologic Oncology Group Study

Context. Women diagnosed with ovarian cancer are at risk for reduced quality of life (QOL). It is imperative to further define these declines to interpret treatment outcomes and design appropriate clinical interventions. Objectives. The primary…

A case of chronic paclitaxel administration in ovarian cancer

Background. Treatment with chemotherapeutic agents, after initial ovarian tumor debulking, and during recurrence, results in extended chemotherapy. When ovarian cancer recurs, chemotherapy is continued when patients respond to therapy. However, the…

Selective lateral compartment neck dissection for thyroid cancer.

BACKGROUND: Compartment-oriented lymph node dissection in patients with thyroid cancer and macroscopic lymph node metastases reduces recurrence and improves survival. However, the extent of lymph node dissection remains controversial. The purpose of…

The Difference in Prognosis between Renal Sinus Fat and Perinephric Fat Invasion for pT3a Renal Cell Carcinoma: A Meta-Analysis.

BACKGROUND: In the current Tumour-Node-Metastasis (TNM) classification system for renal cell carcinoma (RCC), both renal sinus fat invasion (SFI) and perinephric fat invasion (PFI) are defined as T3a, suggesting that the prognosis should be similar…

RADIOTHERAPY AND SURVIVAL IN PROSTATE CANCER PATIENTS: A POPULATION-BASED STUDY

Purpose: To investigate the association of overall and disease-specific survival with the five standard treatment modalities for prostate cancer (CaP): radical prostatectomy (RP), brachytherapy (BT), external beam radiotherapy, androgen deprivation…

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