Browse Items (332 total)
- Tags: Department of Pharmaceutical Sciences
In vivo brain microdialysis: advances in neuropsychopharmacology and drug discovery.
Examining targeted protein degradation from physiological and analytical perspectives: Enabling translation between cells and subjects.
Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers.
Tags: 2017, Animals, Chen Ying, Daurio Natalie A, Department of Pharmaceutical Sciences, Drug Discovery/*methods, Erion Mark D, Humans, Isotope Labeling, Isotopes/chemistry, Johns Douglas G, Kasumov Takhar, Kelley David E, McLaren David G, Metabolic Flux Analysis/*methods, Milot Denise, NEOMED College of Pharmacy, Previs Stephen F, Roddy Thomas P, The Journal of pharmacology and experimental therapeutics, Wang Sheng-Ping, Water/chemistry/metabolism, Zhou Haihong
Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress.
Tags: *ammonia, *ATP, *cellular respiration, *cirrhosis, *Mitochondria, *Oxidative Stress, *portacaval anastamosis, *Reactive oxygen species, *skeletal muscle, 2016, Adenosine Triphosphate/metabolism, Aged, Allawy Allawy, Animals, Cell Line, Cell Respiration, Creatine Kinase/metabolism, Dasarathy Srinivasan, Davuluri Gangarao, Department of Pharmaceutical Sciences, Female, Flask Chris A, Hoppel Charles, Humans, Hyperammonemia/*metabolism, Kasumov Takhar, Kumar Avinash, Liver Cirrhosis/metabolism, Male, Middle Aged, Mitochondria, Muscle, Muscle/*metabolism, Myosin Heavy Chains/metabolism, NAD/metabolism, NEOMED College of Pharmacy, Rats, Reactive Oxygen Species/metabolism, Rennison Julie H, Sandlers Yana, Singh Dharmvir, Skeletal/*metabolism, Sprague-Dawley, Thapaliya Samjhana, The Journal of physiology, Thiobarbituric Acid Reactive Substances/metabolism, Van Wagoner David R
Evidence of Wnt/beta-catenin alterations in brain and bone of a tauopathy mouse model of Alzheimer's disease.
Tags: *Alzheimer's disease, *Beta catenin, *Bone mineral density, *neurodegeneration, *Tauopathy, *Wnt proteins, *Wnt Signaling Pathway, 2018, Alzheimer Disease/*genetics/*metabolism, Animal, Animals, Ball Hope C, beta Catenin/metabolism, Bone and Bones/*metabolism, Bone Density, Bone Remodeling/genetics, Brain/*metabolism, Cooper Lisa Noelle, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Female, Gene Expression, Lin Li, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Neurobiology of aging, Novak Kimberly M, Osteogenesis/genetics, Osteoporosis/etiology/genetics, tau Proteins/*metabolism, Tauopathies/genetics/*metabolism, Wnt Proteins/metabolism
Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA/2J mouse model of glaucoma.
Tags: 2014, Axonal Transport, Axonopathy, Crish Samuel D, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Frontiers in neuroscience, Glaucoma, Inman Denise M, NEOMED College of Medicine, NEOMED College of Pharmacy, Neurodegeneration, ocular, optic nerve, Smith Matthew A, superior colliculi, vision disorders, Wilson Gina N, Young Jesse W
Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease.
Tags: *Alzheimer Disease/complications/genetics/pathology, *Alzheimer's disease, *bone density, *microtubule-associated protein, *serotonin, *tau proteins, *tauopathies, 2017, Age Factors, Alzheimer's disease, Alzheimer's Disease – Complications, Alzheimer's Disease – Pathology, Animal, Animal Studies, Animals, Biological, Body Composition, Body Composition/genetics, Body Weight, Body Weight/genetics, Bone Density – Physiology, Bone Density/*physiology, Bone Diseases – Etiology, Bone Diseases/*etiology, Brain Stem – Pathology, Dengler-Crish Christine M, Department of Pharmaceutical Sciences, Disease Models, Dorsal Raphe Nucleus/*pathology, Female, Inbred C57BL, Journal of Alzheimer's disease : JAD, Male, Mice, Models, NEOMED College of Pharmacy, Nerve Tissue Proteins, Nerve Tissue Proteins – Metabolism, Neurodegenerative Diseases, Neurodegenerative Diseases – Complications, Neurons – Metabolism, Neurons – Pathology, Neurons/metabolism/pathology, Oxidoreductases – Metabolism, Phosphorylation, Serotonin – Metabolism, Serotonin/*metabolism, Smith Matthew A, tau Proteins/*genetics/metabolism, Tauopathies/complications/genetics, Transgenic, Tryptophan Hydroxylase/metabolism, Wilson Gina N
Abnormal Metal Levels In The Primary Visual Pathway Of The Dba/2j Mouse Model Of Glaucoma
Tags: 2014, alzheimers-disease, amyloid-beta, aqueous-humor, Biochemistry & Molecular Biology, Biometals, Braymer J J, Crish S D, Deb A, Dengler-Crish C M, Department of Pharmaceutical Sciences, DeToma A S, ganglion-cell degeneration, gene-expression, Glaucoma, ICP-MS, iron, Lim M H, Microarray Analysis, NEOMED College of Pharmacy, Neurodegeneration, Penner-Hahn J E, retina, superior colliculus, synapse, Van der Schyf C J
Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein.
Tags: *Alpha-synuclein, *ATP13A2, *Mice, *Phenotype, *Sensorimotor, 2018, Adenosine Triphosphatases/*deficiency/genetics, alpha-Synuclein/genetics/*metabolism, Animal, Animals, Behavioural brain research, Blackwood Rachel, Body Temperature, Body Weight, Department of Pharmaceutical Sciences, Dirr Emily R, Disease Models, Ekhator Osunde R, Female, Fleming Sheila M, Gait Disorders, Holden John G, Humans, Inbred C57BL, Male, Masliah Eliezer, Membrane Proteins/*deficiency/genetics, Mice, Motor Skills/physiology, NEOMED College of Pharmacy, Neurologic/*metabolism, Phenotype, Schultheis Patrick J, Severity of Illness Index, Sex Characteristics, Transgenic
Markers associated with sex differences in methamphetamine-induced striatal dopamine neurotoxicity.
Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity.
Tags: 2010, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Age Factors, Animals, Body Temperature/drug effects, Central Nervous System Stimulants/*toxicity, Corpus Striatum/*drug effects/metabolism, Darvesh A S, Department of Pharmaceutical Sciences, Dluzen D E, Dopamine/*metabolism, Female, In Vitro Techniques, Male, McDermott J L, Methamphetamine/*toxicity, Mice, NEOMED College of Pharmacy, Neuroscience, Neurotoxicity Syndromes/etiology/*metabolism/physiopathology, Sex Factors, Time Factors
Isotope Fractionation during Gas Chromatography Can Enhance Mass Spectrometry-Based Measures of (2)H-Labeling of Small Molecules.
Tags: 2020, data integration, Daurio NA, December 2020 List, Department of Pharmaceutical Sciences, Downes DP, gas chromatography-mass spectrometry, isotope fractionation, journalArticle, Kasumov T, McLaren DG, metabolic flux, metabolites, NEOMED College of Pharmacy, Previs MJ, Previs SF, Savitzky-Golay, Sheth PR, Stable isotopes, Wood NB
Sensory Hairs in the Bowhead Whale, Balaena mysticetus (Cetacea, Mammalia).
Tags: 2015, Anatomical record (Hoboken, N.J. : 2007), anatomy, Animals, Bowhead Whale/*anatomy & histology, Cetacea, Crish Samuel D, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Drake Summer E, Epidermis, George John C, hair, Hair/*anatomy & histology, Lip/anatomy & histology, NEOMED College of Medicine, NEOMED College of Pharmacy, Stimmelmayr Raphaella, Thewissen J G M, vibrissa, whale
Exploring the scope of post-intensive care syndrome therapy and care: engagement of non-critical care providers and survivors in a second stakeholders meeting.
Tags: *Health Status, *Intensive Care Units, 2014, Awareness, Bemis-Dougherty Anita, Bienvenu O Joseph, Black Gary, Brady Susan, Brodsky Martin B, Continuity of Patient Care/*organization & administration, Critical care medicine, Critical Illness/*psychology, Davidson Judy E, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Deutschman Cliff, Doepp Diana, Elliott Doug, Flatley Carl, Fosnight Sue, Gittler Michelle, Gomez Belkys Teresa, Harvey Maurene A, Health Education, Hopkins Ramona O, Humans, Hyzy Robert, Iwashyna Theodore J, Louis Deborah, Mandel Ruth, Maxwell Carol, Mental Health, Muldoon Sean R, Needham Dale M, NEOMED College of Pharmacy, Perme Christiane S, Reilly Cynthia, Robinson Marla R, Rubin Eileen, Schmidt David M, Schuller Jessica, Scruth Elizabeth, Siegal Eric, Spill Gayle R, Sprenger Sharon, Straumanis John P, Survivors/*psychology, Sutton Pat, Swoboda Sandy M, Syndrome, Twaddle Martha L, United States, Wagner Jason, Weinert Craig, Wunsch Hannah
Preparation of emulsifying wax/glyceryl monooleate nanoparticles and evaluation as a delivery system for repurposing simvastatin in bone regeneration.
Tags: 2018, Animals, Bone, Bone Regeneration/*drug effects/physiology, Czech Tori, Department of Pharmaceutical Sciences, Drug delivery, Drug Delivery Systems/*methods, Drug development and industrial pharmacy, Drug Evaluation, Drug Repositioning/methods, Emulsifying Agents/administration & dosage/*chemical synthesis, Eskinazi-Budge Aaron, Glycerides/administration & dosage/*chemical synthesis, Kunzler James, Manickavasagam Dharani, Mice, nanoemulsions, Nanoparticles, Nanoparticles/administration & dosage/*chemistry, NEOMED College of Pharmacy, Novak Kimberly, Osteoblasts, Osteoblasts/drug effects/physiology, Osteoclasts, Oyewumi Moses O, Preclinical/methods, RAW 264.7 Cells, Simvastatin/administration & dosage/*chemical synthesis, Waxes/chemical synthesis/pharmacology
Mechanisms of Gene-Environment Interactions in Parkinson's Disease.
Tags: *Alpha-synuclein, *ATP13A2, *Gene-Environment Interaction, *Genetic Predisposition to Disease, *Manganese, *Paraquat, *Parkinson Disease, *Parkinson's disease, *Rotenone, 2017, Current environmental health reports, Department of Pharmaceutical Sciences, Environmental Exposure/*adverse effects, Fleming Sheila M, Herbicides/adverse effects, Humans, Insecticides/adverse effects, Mutation/genetics, NEOMED College of Pharmacy, Paraquat/adverse effects, Risk Factors, Rotenone/adverse effects
The effect of manganese exposure in Atp13a2-deficient mice.
Tags: *Alpha-synuclein, *Lipofuscin, *Manganese, *Mice, *Parkinson's disease, *Sensorimotor function, 2018, Aga Diana S, Department of Pharmaceutical Sciences, Ekhator Osunde R, Fleming Sheila M, Holden John G, Karkare Swagata, Lemkuhl Andrew, Linn Stephen C, Liou Benjamin, Mullin Elizabeth J, NEOMED College of Pharmacy, Neurotoxicology, Pamphile Shanta, Roth Jerome A, Santiago Nicholas A, Schultheis Patrick J, Shull Gary E, Sun Ying
The effect of manganese exposure in Atp13a2-deficient mice.
Tags: *Alpha-synuclein, *Lipofuscin, *Manganese, *Parkinson's disease, *Sensorimotor function, 2018, Adenosine Triphosphatases/genetics/*metabolism, Aga Diana S, alpha-Synuclein/metabolism, Animal, Animals, Behavior, Brain/*drug effects/*metabolism, Department of Pharmaceutical Sciences, Ekhator Osunde R, Female, Fleming Sheila M, Holden John G, Inbred C57BL, Karkare Swagata, Knockout, Lemkuhl Andrew, Linn Stephen C, Liou Benjamin, Male, Manganese/metabolism/*toxicity, Membrane Proteins/genetics/*metabolism, Mice, Motor Activity, Mullin Elizabeth J, NEOMED College of Pharmacy, Neurotoxicology, Pamphile Shanta, Roth Jerome A, Santiago Nicholas A, Schultheis Patrick J, Shull Gary E, Sun Ying
Vitamin D supplementation to prevent falls in the elderly: evidence and practical considerations.
Tags: 2008, 80 and over, Accidental Falls/*prevention & control/statistics & numerical data, Aged, Calcium/administration & dosage/therapeutic use, Cholecalciferol/administration & dosage/therapeutic use, Department of Family & Community Medicine, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Ergocalciferols/administration & dosage/therapeutic use, Fosnight Susan M, Hazelett Susan E, Humans, NEOMED College of Medicine, NEOMED College of Pharmacy, Patient Education as Topic, Pharmaceutical Services, Pharmacotherapy, Vitamin D/administration & dosage/*therapeutic use, Vitamins/administration & dosage/*therapeutic use, Zafirau William J
Mechanistic complexities of bone loss in Alzheimer's disease: a review
Mechanistic complexities of bone loss in Alzheimer's disease: a review.
The role of the community pharmacist in veterinary patient care: A cross-sectional study of pharmacist and veterinarian viewpoints.
Tags: 2020, August 2020 List, Counseling, Dannemiller S, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Drug Compounding, Fredrickson ME, Horne RL, Intersectoral Collaboration, journalArticle, NEOMED College of Pharmacy, NEOMED College of Pharmacy Student, NEOMED Student Publications, Pharmacies, Pharmacists, Pharmacy Practice, Professional Role, Surveys and Questionnaires, Terlizzi H, United States, Veterinarians
Defining α-synuclein species responsible for Parkinson disease phenotypes in mice
Tags: 2019, alpha-synuclein (a-synuclein), amyloid, Anabtawi Nadia M, Camino José D, Castellana-Cruz Marta, Chen Serene W, Cremades Nunilo, cytotoxicity, Department of Pharmaceutical Sciences, Dobson Christopher M, fibril, Fleming Sheila, Freire Jennifer, Froula Jessica M, June 2019 Update, Kumita Janet R, Lewy Body, motor behavior defect, NEOMED College of Pharmacy, neurodegenerative disease, oligomer, Parkinson Disease, Protein Aggregation, The Journal of biological chemistry, Thrasher Drake R, Volpicelli-Daley Laura A, Yazdi Allen A
Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.
Tags: 2019, Anabtawi Nadia M, Camino José D, Castellana-Cruz Marta, Chen Serene W, Cremades Nunilo, Department of Pharmaceutical Sciences, Dobson Christopher M, DOPAMINERGIC neurons, Fleming Sheila, FOURIER transform infrared spectroscopy, Freire Jennifer, Froula Jessica M, Journal of Biological Chemistry, Kumita Janet R, MOUSE diseases, NEOMED College of Pharmacy, Parkinson's disease, September 2019 Update, SPECIES, SUBSTANTIA nigra, Thrasher Drake R, Volpicelli-Daley Laura A, Yazdi Allen A
Anticholinergic therapy for lower urinary tract symptoms associated with benign prostatic hyperplasia.
Tags: 2008, Adrenergic alpha-1 Receptor Antagonists, Cholestenone 5 alpha-Reductase/antagonists & inhibitors, Cholinergic Antagonists/*therapeutic use, Clinical Trials as Topic, Department of Internal Medicine, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Frazee Lawrence A, Gallegos Patrick J, Humans, Male, NEOMED College of Medicine, NEOMED College of Pharmacy, Pharmacotherapy, Prostatic Hyperplasia/complications/*drug therapy/therapy, Quality of Life, Urination Disorders/*drug therapy/etiology/therapy
Parkinson's disease biomarker: a patent evaluation of WO2013153386.
Tags: 2014, Abdelmagid Samir M, Autophagy, Biomarkers/metabolism, clinical testing, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Disease Progression, Dopaminergic Neurons/pathology, Expert opinion on therapeutic patents, Gallegos Patrick J, Geldenhuys Werner J, Humans, Mitochondria/pathology, mitochondrial membrane potential, mitophagy, NEOMED College of Medicine, NEOMED College of Pharmacy, Parkinson Disease/*diagnosis/physiopathology, Patents as Topic, Phosphorylation, Protein Kinases/*metabolism, Safadi Fayez F, Ubiquitin-Protein Ligases/*metabolism
A novel Lipoprotein lipase (LPL) agonist rescues the enzyme from inhibition by angiopoietin-like 4 (ANGPTL4).
Tags: 2014, Angiopoietin-like 4 Protein, Angiopoietins/*metabolism, ANGPTL4, Aring Danielle, Atherosclerosis, Benzamides/pharmacology, Bioorganic & medicinal chemistry letters, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Drug Discovery, Enzyme Activation/*drug effects, Geldenhuys Werner J, High-throughput screen, Homology model, Humans, Ibrolipim, Lipoprotein Lipase/*metabolism, LPL, Molecular Docking Simulation, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, NO-1886, Organophosphorus Compounds/pharmacology, Sadana Prabodh
MitoNEET (CISD1) Knockout Mice Show Signs of Striatal Mitochondrial Dysfunction and a Parkinson's Disease Phenotype.
Tags: *Aging, *Disease Models, *drug discovery, *mitochondrial dysfunction, *mitoNEET, 2017, ACS chemical neuroscience, Animal, Animals, Benkovic Stanley A, Brown Candice M, Corpus Striatum/*metabolism/*pathology, Crish Samuel D, Darvesh Altaf S, Department of Pharmaceutical Sciences, Geldenhuys Werner J, Inbred C57BL, Iron-Binding Proteins/genetics/*metabolism, Knockout, Lin Li, Male, Membrane Proteins/genetics/*metabolism, Mice, Mitochondria/*metabolism/*pathology, NEOMED College of Pharmacy, Parkinson Disease/*metabolism/pathology, Richardson Jason R, Sullivan Patrick G, Yonutas Heather M
Natural products of dietary origin as lead compounds in virtual screening and drug design.
Tags: *Biological Products/pharmacology, *Drug Design, 2012, Animals, Bishayee Anupam, Caffeine/pharmacology, Carroll Richard T, Curcumin/pharmacology, Current pharmaceutical biotechnology, Darvesh Altaf S, Department of Pharmaceutical Sciences, Diet, Geldenhuys Werner J, Genistein/pharmacology, Humans, NEOMED College of Pharmacy, Resveratrol, Stilbenes/pharmacology
Structure-activity and in vivo evaluation of a novel lipoprotein lipase (LPL) activator.
Tags: *Diabetes, *High-fat diet, *Homology modeling, *Hyperlipidemia, *Lipoprotein lipase, *Liver cirrhosis, *Obesity, 2017, Animals, Benzeneacetamides/chemical synthesis/chemistry/*pharmacology, Bioorganic & medicinal chemistry letters, Caporoso Joel, Darvesh Altaf S, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dose-Response Relationship, Drug, Geldenhuys Werner J, Imidazoles/chemical synthesis/chemistry/*pharmacology, Lee Yoon-Kwang, Leeper Thomas C, Lin Li, Lipoprotein Lipase/*metabolism, Mice, Molecular Docking Simulation, Molecular Structure, NEOMED College of Graduate Studies, NEOMED College of Medicine, NEOMED College of Pharmacy, Sadana Prabodh, Structure-Activity Relationship
Evolution of a Natural Products and Nutraceuticals Course in the Pharmacy Curriculum.
Tags: *Biological Products/therapeutic use, *Clinical Competence, *Dietary Supplements, *Students, 2015, American journal of pharmaceutical education, course curriculum, Cudnik Michelle L, Curriculum/*trends, Darvesh Altaf S, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Dietary Supplements, Education, Educational Measurement/methods, Evidence-Based Medicine, Geldenhuys Werner J, herbal products, Humans, Krinsky Daniel L, NEOMED College of Pharmacy, Nutraceuticals, Pharmacy, Pharmacy/methods/*trends